Inhaled tiny mica flakes and vitamin B12 intercalated clay dust induce multiple sclerosis

Abstract

The incidence and prevalence of multiple sclerosis (MS) have increased much since 1950s. Environmental factors must play a decisive role because the heredity can not be mutated so fast. No one has proposed the mechanical pathway between MS and environmental factors. The aim of this study is to reveal what environmental factors induce multiple sclerosis. From animal models it is known that aggresive T cells (able to cross bloob-brain barrier) are induced in lung. Soil dust containing both weathered mica particles and vitamin B12 containing clay particles ("transformation smectite" particles) can activate myelin specific CD4+ T cells in lung. CD4+ central memory type T cell (resting phenotype) receptor is activated by soluble MHC II when it is anchored on mica particle surface and T cell adheres also on the same mica surface. Further prerequisite is that at the same time smectite clay particle intercalated with vitamin B 12 is endocytosed into the same T cell. T cell activation requires 1) T cell receptor activation and 2) T cell metabolic changes from oxidative phosphorylation to aerobic glycolysis. In classical activation model co-receptor B 28 activation changes T cell metabolism to oxidative glycolysis. In this case at the wrong time dosed vitamin B 12 changes T cell metabolism to oxidative glycolysis using anaplerotic feeding of TCA-cycle, permitting T cell activation to effector phenotype aggressive T cell. The hypothesis is based on new findings in immunobiology and on epidemiological observations.