Inhibin: A new circulating marker of hydatidiform mole?

Yohkaichiya, Takashi; Fukaya, Takao; Hoshiai, Hiroshi; Yajima, Aiji; Kretser, DM de

doi:10.1016/0020-7292(90)90209-4

Cited by 10 publications

(16 citation statements)

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“…Increased levels of circulating inhibin have previously been reported in molar pregnancy, and inhibin concentrations have been suggested to be a marker of hydatidiform mole (HM) [1,2]. However, inhibin assays used in these studies could not differentiate circulating inhibin forms.…”

Section: Introductioncontrasting

confidence: 42%

“…While the pro-·C ELISA detects a range of inhibin · subunit-containing molecules including some forms of inhibin-A and inhibin-B dimer, it is considered likely that the major inhibin form detected by this assay is free ·-subunit. The increased inhibin level previously found in molar pregnancy [1,2] might have reflected an increase of the free ·-subunit. In early pregnancy in normal women, the major source of inhibin A is the fetoplacental unit [3,10].…”

Section: Discussionmentioning

confidence: 98%

“…Yohkaichiya et al [1] suggested that serum inhibin concentrations may be of value in the management of trophoblastic disease. Badonnel et al [2] also found increased concentrations of inhibin in HM.…”

Section: Discussionmentioning

confidence: 99%

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Circulating Inhibin Forms in Patients with Hydatidiform Mole

Katō

Seki²,

Sekiya³

2002

Gynecol Obstet Invest

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Circulating inhibin forms have not been evaluated in patients with hydatidiform mole (HM) before evacuation of the mole. Serum inhibin A, inhibin B, pro-αC and hCG levels were determined by enzyme-linked immunosorbent assay in HM before and after evacuation of the mole (inhibin B only before evacuation). Before evacuation, inhibin B levels in HM were undetectable, and inhibin A levels were similar to those in normal women at the corresponding weeks of pregnancy. Pro-αC and hCG levels were higher in molar pregnancy than in normal pregnancy. After evacuation, pro-αC levels significantly fell in the patients with spontaneous resolution, but not in those who developed persistent trophoblastic disease (PTD). Both pro-αC and hCG levels were higher in the patients with PTD than in those with spontaneous resolution after evacuation, reflecting continued stimulation of the corpus luteum by lower, but still effective hCG levels, persistent trophoblastic tissues secreting pro-αC or both.

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Section: Introductioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 98%

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Circulating Inhibin Forms in Patients with Hydatidiform Mole

Katō

Seki²,

Sekiya³

2002

Gynecol Obstet Invest

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“…Recent studies indicated that inhibin and activin are expressed in a wide variety of tissues and have a critical role in growth and developmental mechanisms, modulating the proliferation and differentiation of several cell types (2,3). The expression and secretion of inhibin and related proteins in various tumours is currently under investigation (4)(5)(6)(7)(8)(9)(10). The tumoral secretion of inhibin and activin into systemic circulation is suggested by the high serum levels of immunoreactive inhibin in women with ovarian or placental carcinoma (4,5), and by the high levels of serum activin A associated with solid tumours (9,10).…”

Section: Introductionmentioning

confidence: 99%

Human mammary gland and breast carcinoma contain immunoreactive inhibin/activin subunits: evidence for a secretion into cystic fluid

Loreto

Reis²,

Cataldi³

et al. 1999

European Journal of Endocrinology

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Objective: Inhibins and activins are members of the transforming growth factor b superfamily and are known to modulate the growth and differentiation of several cell types. The present study investigated the localization of inhibin and activin subunits in human normal and pathological breast tissues. Design: A cross-sectional study comparing the expression of inhibin/activin subunits a, bA and bB in surgical specimens from women undergoing reductive mammoplasty (classified, according to the phase of the menstrual cycle, as follicular, luteal, or postmenopausal), and patients submitted to lumpectomy for fibrocystic disease, benign (intraductal papilloma, adenomyoepithelioma, and hamartoma) or malignant breast neoplams (intraductal, intralobular, and invasive carcinoma). Methods: Immunohistochemistry was used to localize inhibin a and activin bA and bB subunits in the cytoplasm of epithelial cells of mammary glands. Dimeric activin A, inhibin A and inhibin B were measured by specific two-site enzyme immunoassay in the cystic fluid collected from patients with fibrocystic disease. Results: An intense staining for the a inhibin subunit and a mild staining for bA and bB subunits were present in samples obtained from normal breast tissue regardless of menstrual cycle phase, and in fibrocystic disease and benign neoplasms. Carcinoma cells stained weakly to moderately for a subunit and were negative for bA and bB subunits. Fibrocystic disease was associated with absence of bA subunit expression in normal epithelial cells and intense staining for all subunits in the apocrine cells. Immunoreactive inhibin A, inhibin B, and activin A were also present in cystic fluid, suggesting a local secretion of these proteins. Conclusion: These data suggest a local expression and secretion of inhibin and activin in human normal, fibrocystic disease and neoplastic breast tissues. The low expression of these proteins may facilitate abnormal cell proliferation in breast carcinoma.

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“…Moreover, serial measurement of inhibin has been suggested as a marker of follicular development in In Vitro Fertilization program (Tsuchiya et al 1989) and as a tumor marker viz, in hydatidiform mole (Yohkaichiya et al 1989) or granulosa cell tumor (Lappoehn et al 1989).…”

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confidence: 99%