Abstract:In solid malignancies such as breast cancer, the tumor cells create an immunosuppressive environment through the aid of macrophages. The macrophages become tumor-associated and inhibit a T-cell response critical to removing the cancerous cells. The main signaling pathway responsible for the macrophages’ pro-tumoral behavior is the STAT3 signaling pathway, a subset of the JAK/STAT signaling pathway that prevents the toll-like receptor (TLR) expression. TLRs are essential to the immune system's anti-tumoral resp… Show more
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