Inhibition of caerulein-induced gall bladder emptying by cimetropium bromide in humans

Gullo, Lucio; Scarpignato, Carmelo; Casanova, P.; Corcioni, E.; Zappia, L; Imbimbo, Bruno P.

doi:10.1007/bf00558128

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…In humans, it reduces the motor responses of the colon to eating [10,11], shortens intestinal transit time in patients with irritable bowel syndrome [18] and delays fatty meal-and cerulein-induced gallbladder emptying [7,19,20], No data are available from these studies on duration of action and potency in comparison to other drugs. The present study found that cimetro pium and atropine had a similar maximal inhibitory activity on esophageal motility, though the duration of the effect was shorter (less than 60 min) for cimetropium.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Effects of Cimetropium Bromide and Atropine on Human Esophageal Motor Functions

Marzio

Pieramico²,

Neri³

et al. 1989

Digestion

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The effects of atropine and cimetropium bromide, a new antimuscarinic compound with strong spasmolytic properties, were studied on human esophageal motility. Twenty healthy subjects underwent esophageal manometry with continuous monitoring of lower esophageal sphincter pressure (LESP), and of amplitude, duration and velocity of contractions of the esophageal body. After a 30-min basal period, atropine (12 µg/kg) or cimetropium (5 mg) were administered as an intravenous bolus in a cross-over random manner and the recording was continued for another 60 min. Twenty minutes after injection, atropine and cimetropium decreased maximally, in a similar extent, both the amplitude of contractions of the esophageal body (-65% of the basal values) and the LESP (-30% of the basal values). The duration and propagation velocity of the esophageal contractions did not change significantly after both drugs. Sixty minutes after injection of cimetropium, the amplitude of contractions of the esophageal body and LESP returned to basal values while atropine still reduced both variables. These findings indicate that cimetropium bromide has an inhibitory effect on LESP and on the amplitude of contractions of the esophageal body similar to atropine, but its action lasts less time.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of the Effects of Cimetropium Bromide and Atropine on Human Esophageal Motor Functions

Marzio

Pieramico²,

Neri³

et al. 1989

Digestion

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show abstract

“…The composition of the test meal was as follows: fat 8.2 g (41 %), protein 2.2 g (1 1 %) and carbohydrate 9 .6 g (48%). The choice of cerulcin doses was based on previous studies from our laboratory showing that 10 ng/kg/h is the lowest dose capable of significantly contracting the gallbladder and that the dose of 40 ng/kg/h causes an almost complete contraction o f this organ [ 14], On the other day, neuro tensin (Peninsula Laboratories Europe Ltd., Mersey side. UK.)…”

Section: Methodsmentioning

confidence: 99%

Study of the Effect of Neurotensin on Meal- and Cerulein-lnduced Gallbladder Contraction

Gullo

Ancona²,

Pezzilli³

et al. 1992

Digestion

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We studied the effect of a low dose of neurotensin (2.5 pmol/kg/min) on meal- and cerulein-induced gallbladder contraction in 11 healthy volunteers by means of real-time ultrasonography. Ingestion of a meal caused a significant reduction in gallbladder volume which reached a maximum of 57 ± 2% of the basal value at 60 min after the meal. The infusion of neurotensin caused a slight but not significant attenuation of the contractile response of the gallbladder to the meal (maximal reduction of 49 ± 6%). Increasing doses of cerulein (10, 20 and 40 ng/kg/h, for 30 min at each dose) caused progressive reductions in gallbladder volume of 18 ± 5, 72 ± 5 and 89 ± 4% with the three respective doses of cerulein used. The simultaneous administration of neurotensin did not significantly modify the gallbladder response to cerulein. The results indicate that neurotensin, at a dose of 2.5 pmol/kg/min, does not influence the gallbladder contraction stimulated by food or cerulein.

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Effect of trospium chloride on gastrointestinal motility in humans

Pfeiffer

Schmidt

Höller

et al. 1993

Eur J Clin Pharmacol

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The aim of this double-blind, placebo-controlled, cross-over study was to investigate the effect of trospium chloride on gall bladder contraction, gastric emptying of a liquid meal, gastrooesophageal reflux, and orocaecal transit time in healthy subjects. Gall bladder contraction was examined by ultrasonography before and after stimulation with two raw eggs. Gastric emptying was evaluated by an intubation technique and by sonography. To determine gastrooesophageal reflux and orocaecal transit time, 24-hour pH metry and a hydrogen breath test were used. The gall bladder ejection fractions were significantly lower after oral treatment with both 4 x 10 mg and 4 x 20 mg trospium compared to placebo, but no difference was seen between the two doses of drug. Gastric emptying of a liquid meal was significantly delayed after intake of 4 x 15 mg trospium, whilst the time course of the intragastric volume determined by ultrasound did not differ from that after placebo, suggesting an antisecretory effect of trospium on gastric secretion. The fractional time of oesophageal pH < 4 as a percentage of the entire 24-hour investigation period was significantly increased by treatment with trospium 3 x 15 mg per day. The orocaecal transit time of 10 g lactulose was significantly prolonged. Provided that the observed effects on gall bladder contraction, gastric emptying, and orocaecal transit time are reproduced in disease states, trospium should be regarded as a potentially useful antispasmodic agent.

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Inhibition of caerulein-induced gall bladder emptying by cimetropium bromide in humans

Cited by 4 publications

References 11 publications

Comparative Study of the Effects of Cimetropium Bromide and Atropine on Human Esophageal Motor Functions

Comparative Study of the Effects of Cimetropium Bromide and Atropine on Human Esophageal Motor Functions

Study of the Effect of Neurotensin on Meal- and Cerulein-lnduced Gallbladder Contraction

Effect of trospium chloride on gastrointestinal motility in humans

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