Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: A psychotropic effect

Tonoue, Teiichiro; Ashida, Yasunobu; Makino, Hiroyasu; Hata, Hideaki

doi:10.1016/0306-4530(86)90052-1

Cited by 125 publications

(78 citation statements)

References 11 publications

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“…Thus, we can hypothesize that the treatment with PCP in perinatal rats described in this study induces dorsal hippocampal dysfunction by alteration of the glutamatergic system. The lack of treatment effect observed when testing rats in the USV test, a model sensitive to anxiogenic treatments (Tonoue et al, 1986), confirmed that the male PCP-treated rats were not swimming along the sidewall because of an anxiogenic effect of PCP treatment, but because of a welladapted search strategy.…”

Section: Discussionmentioning

confidence: 81%

“…D-Serine was selected due to its well-described clinical add-on effect on cognitive dysfunction in patients with schizophrenia (Tsai et al, 1998), and was expected to be superior to the effect of marketed antipsychotics for the treatment of this symptom (Sharma and Antonova, 2003). Finally, we tested the rats from the first experiment in the ultrasound vocalization (USV) model (Tonoue et al, 1986;Branchi et al, 2001), validated for the screening of anxiolytic drugs (Sánchez, 1993), to exclude the possibility that cognitive deficits might be associated with an anxiogenic effect of perinatal treatment with PCP.…”

Section: Introductionmentioning

confidence: 99%

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Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Andersen

Pouzet

2004

Neuropsychopharmacol

119

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It has been suggested that perinatal treatment with the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) induces transient neurodegeneration in the limbic and cortical structures of rats. Since dysfunction of these structures is associated with cognitive deficits in patients with schizophrenia, we studied the effects of subchronic treatment with PCP in perinatal rats with respect to spatial reference, reversal, and spatial working memories using the Morris water maze task in adulthood. In addition, we investigated the effect of D-serine, which has clinical relevance for the treatment of cognitive deficits in patients with schizophrenia. Our goal was to develop a neurodevelopmental model with predictive validity for the cognitive dysfunction described in patients with schizophrenia. Male and female Sprague-Dawley rats were treated with either saline or PCP (8.7 mg/kg s.c.) on days 7, 9, and 11, postnatal, and the long-term behavioral effects were investigated in adulthood. Male PCP-treated rats were slightly impaired during the spatial reference memory task, but strongly impaired during the reversal and spatial working memory tasks. Female rats were not significantly affected by this treatment. This cognitive deficit was reversed by chronic treatment with D-serine. We suggest that this model mimics some of the cognitive deficits of patients with schizophrenia and might be appropriate for the screening of putative antipsychotic agents for the treatment of these cognitive deficits.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Andersen

Pouzet

2004

Neuropsychopharmacol

119

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“…Tonoue et al [16] and Kaltwasser [5] reported that USV responses were elicited in only 50-70% of all rats by either electric foot-shocks or by acoustic stimuli, though Knapp and Pohorecky [7] reported that nearly all rats tested were able to elicit the USV response by air-puff stimuli. The cause of these differences in USV response inducibility was not clarified, though the high-emotionality of the rat may act as a important factor in the elicitation of the USV response as indicated in our previous findings [13].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonic vocalizations (USV), i.e., ultrasonic distress calls, in the 20-30 kHz range have been elicited in adult rats under stressful and painful situations such as electric shocks applied to the feet [1,14,16] or the tail [18] and acoustic startle [5,6,9,19]. In view of the behavioral contexts in which USV are emitted, they are often interpreted as expressions of "fear" or "anxiety" [1,8].…”

Section: Introductionmentioning

confidence: 99%

“…In view of the behavioral contexts in which USV are emitted, they are often interpreted as expressions of "fear" or "anxiety" [1,8]. Many attempts have been made to develop animal models to test the anxiolytic effects of drugs [2,6,10,16]. Suppression by anxiolytics of electric shockelicited or acoustic startle-elicited USV in adult rats have been proposed as animal models of psychopharmacology of anxiolytic action which are behaviorally compatible with human anxiolytic function.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

et al. 2003

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Abstract:Ultrasonic vocalization (USV) responses elicited by air-puff stimuli were compared in regard to both quality and quantity with those elicited by electric foot-shock(s) in adult rats. Frequency pattern, duration, repetition rate and interpulse interval of air-puffelicited USV were comparable to those observed on foot-shock-elicited USV. Diazepam (0.25-1.0 mg/kg, s.c.) and buspirone (0.1-1.0 mg/kg, s.c.) attenuated equally and dosedependently the USV responses elicited by both aversive stimuli. Air-puff-elicited USV was specifically attenuated in a dose-dependent manner by the anxiolytic properties of several psychotropic agents: diazepam (1.0-10.0 mg/kg, p.o.), buspirone (10.0-100.0 mg/kg, p.o.), 8-OH-DPAT (0.01-0.5 mg/kg, s.c.). Haloperidol (0.2-1.0 mg/kg, s.c.) weakly attenuated the USV response. Imipramine (0.2-1.0 mg/kg, s.c.) which has no anxiolytic property had no effect. Consequently, air-puff-elicited USV as well as foot-shock-elicited USV may provide a reliable tool for the study of anxiety.

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Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivation

Harmon

Cromwell

Burgdorf

et al. 2008

Developmental Psychobiology

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In rats, the rates of 50 kHz ultrasonic vocalizations (USVs) can be used as a selective breeding phenotype and variations in this phenotype can be an indicator of affective states. The 50 kHz USV is elicited by rewarding stimuli (e.g., food, sexual behavior) and therefore can express a positive affective state. Conversely, the 22 kHz USV is elicited by aversive stimuli (e.g., presence of a predator, social defeat) indicating a negative affective state. In the present study, we tested the effect of selectively breeding for 50 kHz USVs on a variety of maternal social/emotional behaviors in young rat pups (PND 10-12). These measures consisted of an assessment of isolation calls and conditioned odor preference paradigm. Results indicate that animals selected for low levels of 50 kHz USVs show the greatest alterations in social behaviors compared to the control animals. The low line animals had an increase in isolation calls tested during place preference conditioning and a decrease in 50 kHz ultrasonic calls in all conditions. These same low line animals failed to show a typical preference for a maternally-associated odor during the place preference test. The different social behaviors of the high line animals did not consistently vary from those of the control group. These results have important implications for the study of genetic and epigenetic mechanisms underlying emotional states, and possibly contribute to the research underlying the emotional changes in developmental disorders such as autistic spectrum disorder by providing a novel animal model that displays communication deficits that are interdependent with significant social behavioral impairments.

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Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: A psychotropic effect

Cited by 125 publications

References 11 publications

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats

Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivation

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