Inhibitory effect of 5‐hydroxytryptamine on penile erectile function in the rat

Finberg, J. P. M.; Vardi, Yoram

doi:10.1111/j.1476-5381.1990.tb14143.x

Cited by 30 publications

(20 citation statements)

References 20 publications

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“…Thus, 8-OH-DPAT, which facilitates the ejaculatory behaviour, inhibits penile erections (Mathes et al, 1990;Finberg & Vardi, 1990). Furthermore, the non-selective 5-HT 1B receptor agonist 1-(3'-chlorophenyl)-piperazine (mCPP) induces penile erections (Berendsen & Broekkamp, 1987, c.f.…”

Section: Discussionmentioning

confidence: 99%

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Hillegaart

Ahlénius

1998

British J Pharmacology

118

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1 Ejaculatory problems and anorgasmia are well-known side-e ects of the SSRI antidepressants, and a pharmacologically induced increase in serotonergic neurotransmission inhibits ejaculatory behaviour in the rat. In the present study the role of 5-HT 1A and 5-HT 1B receptors in the mediation of male rat ejaculatory behaviour was examined by use of selective agonists and antagonists acting at these 5-HT receptor subtypes. 2 The 5-HT 1A receptor agonist 8-OH-DPAT (0.25 ± 4.00 mmol kg 71 s.c.) produced an expected facilitation of the male rat ejaculatory behaviour, and this e ect was fully antagonized by pretreatment with the new selective 5-HT 1A receptor antagonist (R)-3-N,N-dicyclobutylamino-8-¯uoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R) tartrate monohydrate (NAD-299) (1.0 mmol kg 71 s.c.). NAD-299 by itself (0.75 ± 3.00 mmol kg 71 s.c.) did not a ect the male rat ejaculatory behaviour. 3 The 5-HT 1B receptor agonist anpirtoline (0.25 ± 4.00 mmol kg 71 s.c.) produced a dose-dependent inhibition of the male rat ejaculatory behaviour, and this e ect was fully antagonized by pretreatment with the 5-HT 1B receptor antagonist isamoltane (16 mmol kg 71 s.c.) as well as by the new and selective antagonist (R)-(+)-2-(3-morpholinomethyl-2H-chromene-8-yl)oxymethylmorpholino methansulphonate (NAS-181) (16 mmol kg 71 s.c.). Isamoltane (1.0 ± 16.0 mmol kg 71 s.c.) and NAD-181 (1.0 ± 16.0 mmol kg 71 s.c.) had no, or weakly facilitatory e ects on the male rat ejaculatory behaviour. The non-selective 5-HT 1 receptor antagonist (7)-pindolol (8 mmol kg 71 s.c.), did not antagonize the inhibition produced by anpirtoline.4 The present results demonstrate opposite e ects, facilitation and inhibition, of male rat ejaculatory behaviour by stimulation of 5-HT 1A and 5-HT 1B receptors, respectively, suggesting that the SSRIinduced inhibition of male ejaculatory dysfunction is due to 5-HT 1B receptor stimulation.

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Section: Discussionmentioning

confidence: 99%

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Hillegaart

Ahlénius

1998

British J Pharmacology

118

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“…However, the importance of peripheral 5-HT receptors is less well established. Finberg and Vardi (1990) demonstrated an in vivo 5-HT-mediated inhibitory action on penile erection in rats as a result of vasoconstriction of the cavernosal arteries. In addition, Esen et al (1997) showed that the in vitro 5-HT-mediated contractile response in human penile veins was augmented in patients with venoocclusive disease.…”

Section: F Serotoninmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…7 Serotonin, by a peripheral mechanism, exerts an inhibitory action on penile erection through the activation of 5-HT 1D type of receptor. 12 On the other hand, p-chloroamphetamine (5-HT releasing agent) causes penile erection and ejaculation in anesthetized rats, which is limited to the lower spinal cord and/or peripheral sites. 13 Therefore, there is a difference in the peripheral action of 5-HT when comparing in vivo and in vitro experiments.…”

Section: Discussionmentioning

confidence: 99%

Investigation of serotonin receptors in the isolated penile bulb of rats

2006

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The aim of this study was to investigate serotonin (5-HT) receptors in the penile bulb, which have been suggested to play a role in penile erection. Serotonin (10 À5 M) and L-NOARG (nitric oxide synthase inhibitor, 10 À4 M) had no effect on prucalopride-induced relaxation. These results suggest the existence of a 1 -adrenergic, 5-HT 1A and 5-HT 2A serotonergic receptors in the penile bulb of rats, which are responsible for 5-HT-induced contraction. Additionally, a serotonergic receptor resembling a 5-HT 4 -type plays a role in the relaxation. The latter receptor is activated by 5-HT 4 agonists, but is not antagonized by 5-HT 4 antagonists.

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Inhibitory effect of 5‐hydroxytryptamine on penile erectile function in the rat

Abstract: 1 An increase in corporal pressure was elicited in pithed rats by stimulation of the sacral part of the spinal cord. This response was inhibited by intravenous injection of 5-hydroxytryptamine (5-HT) (ED50 = 28.5 + 2.2pgkg-1).

Cited by 30 publications

References 20 publications

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Investigation of serotonin receptors in the isolated penile bulb of rats

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Inhibitory effect of 5‐hydroxytryptamine on penile erectile function in the rat

Abstract: 1 An increase in corporal pressure was elicited in pithed rats by stimulation of the sacral part of the spinal cord. This response was inhibited by intravenous injection of 5-hydroxytryptamine (5-HT) (ED50 = 28.5 + 2.2pgkg-1).

Cited by 30 publications

References 20 publications

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT1Aand 5‐HT1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT1Aand 5‐HT1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Investigation of serotonin receptors in the isolated penile bulb of rats

Contact Info

Product

Resources

About

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT_1Aand 5‐HT_1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181