Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice

Takahashi, Takuya; Satou, Mikiko; Watanabe, Nami; Sakaitani, Yukiko; Takagi, Akimitsu; Uchida, Kazumi; Ikeda, Masakazu; Moriyama, Rika; Matsumoto, Kunihiro; Morotomi, Masami

doi:10.1016/s0304-3835(99)00096-8

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…A significant protection by wheat bran is shown in two out of twelve publications (80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). Meta-analysis, including 1164 rats, showed that wheat bran reduces colon tumour incidence in rats (RR= 0.83, p=0.0002), with similar RR in Random model analysis (0.87, p=0.015).…”

Section: Wheat Bran Effect In Carcinogen-injected Ratsmentioning

confidence: 86%

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men

Corpet

Pierre

2005

European Journal of Cancer

201

128

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To cite this version:Denis E Corpet, Fabrice Pierre. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men.. European Journal of Cancer, Elsevier, 2005, 41 (13), pp.1911-22. <10.1016/j.ejca.2005.06.006>. D.E. Corpet, F. Pierre / European Journal of Cancer 41 (2005) 1911-1922 AbstractTumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, betacarotene, calcium, and wheat bran studies. Controlled intervention studies of adenoma recurrence in human volunteers were compared with chemoprevention studies of carcinogen-induced tumours in rats, and of polyps in Min (Apc(+/-)) mice: 6714 volunteers, 3911 rats and 458 mice were included in the meta-analyses. Difference between models was small since most global relative risks were between 0.76 and 1.00. A closer look showed that carcinogen-induced rat studies matched human trials for aspirin, calcium, carotene, and were compatible for wheat bran. Min mice results were compatible with human results for aspirin, but discordant for calcium and wheat bran (no carotene study). These few results suggest that rodent models roughly predict effect in humans, but the prediction is not accurate for all agents. Based on three cases only, the carcinogen-induced rat model seems better than the Min mouse model. However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention.

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Section: Wheat Bran Effect In Carcinogen-injected Ratsmentioning

confidence: 86%

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men

Corpet

Pierre

2005

European Journal of Cancer

201

128

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“…Moreover, a lower butyrate to acetate ratio has been found in luminal samples of patients with adenomatous polyps or colon cancer vs. healthy controls 60 . Although several well‐designed animal models have demonstrated a protective effect of butyrate on colorectal carcinogenesis, 55, 61–67 direct evidence for a protective effect of butyrate on carcinogenesis in humans is still lacking.…”

Section: Butyrate and Colon Carcinogenesismentioning

confidence: 99%

Review article: the role of butyrate on colonic function

Hamer¹,

Jonkers²,

Venema³

et al. 2007

Aliment Pharmacol Ther

2,265

1,612

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“…High dietary fiber intake is reported to increase the phylum Bacteroidetes in the intestine of mammals such as mouse, pig and human (Miyazato et al, 2016;Magistrelli et al, 2016;Sheflin et al, 2016). Previous studies have shown that 8-week intake of whole-grain wheat increases the ratio of Bacteroidetes at the phylum level and Prevotella at the genus level in human (Vitaglione et al, 2015), and that SCFA production in mice is elevated by long-term intake (4 weeks) of whole wheat and wheat bran (Garcia-Mazcorro et al, 2016;Takahashi et al, 1999). In this study, the ratio of the phylum Bacteroidetes and SCFA production in murine feces were increased, even in the short term, by wheat bran intake.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that long-term intake of wheat bran induces SCFA production and inhibits colon carcinogenesis in mice (for 33 weeks), and reduces the risk of diabetes in rats (16 weeks) (Takahashi et al, 1999;Numan and Rabah, 2015). Other studies have shown that SCFA production is increased in vitro by fermentation of fecal bacteria using wheat bran with smaller-size particle (90 μm of diameter) rather than larger-size particle (500 μm) (Dziedzic et al, 2016), but no such production was observed in the cases of particle sizes of 551 μm and 1,239 μm in vitro (Stewart and Slavin, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Short-Term Intake of Wheat Bran with Different Particle Sizes on the Murine Intestinal Environment

Iwai

Yoshikawa

Miyoshi

et al. 2017

FSTR

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Wheat bran has a high dietary fiber content. In this study, we investigated the effects of short-term intake of wheat bran on intestinal environment in a murine model. Mice were fed with AIN-93G for 1 week, followed by experimental diets containing wheat bran with an average particle size of 53 μm (powdered) or 350 μm (granulated) for 1 additional week. During a 4-week period (twice-repeated feeding cycles), the ratio of bacteria belonging to the families Prevotellaceae and S24-7 increased in murine feces after intake of both particle-size diets. Furthermore, the amount of short fatty acids, particularly butyric acid, and cecal immunoglobulin A were significantly increased in the powdered wheat bran group, probably by the changes in intestinal microbiota composition. These findings may potentially explain many of the health benefits through the alteration of intestinal microbiota, even after short-term intake of wheat bran.

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Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice

Cited by 15 publications

References 17 publications

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men

Review article: the role of butyrate on colonic function

Effects of Short-Term Intake of Wheat Bran with Different Particle Sizes on the Murine Intestinal Environment

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