Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Kempuraj, Duraisamy; Castellani, M.L.; Petrarca, Claudia; Frydas, S.; Conti, Pio; Theoharides, Theoharis C.; Vecchiet, Jacopo

doi:10.1007/s10238-006-0114-7

Cited by 53 publications

(34 citation statements)

References 51 publications

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“…In the year 2006 a study conducted by Kempuraj et al showed that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the downregulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1. As quercetin dramatically inhibits mast cell tryptase, IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation 89 .…”

Section: 88mentioning

confidence: 65%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

239

198

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Associative evidence from observational and intervention studies in human subjects shows that a diet including plant foods (particularly fruit and vegetables rich in antioxidants) conveys health benefits. There is no evidence that any particular nutrient or class of bioactive substances makes a special contribution to these benefits. Flavonoids occur naturally in fruits, vegetables and beverages such as tea and wine. Quercetin is the major flavonoid which belongs to the class called flavonols. Quercetin is found in many common foods including apples, tea, onions, nuts, berries, cauliflower, cabbage and many other foods. Quercetin provides many health promoting benefits, including improvement of cardiovascular health, eye diseases, allergic disorders, arthritis, reducing risk for cancers and many more. The main aim of this review is to obtain a further understanding of the reported beneficial health effects of Quercetin, its pharmacological effects, clinical application and also to evaluate its safety.

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Section: 88mentioning

confidence: 65%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

239

198

View full text Add to dashboard Cite

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“…Many previous findings have demonstrated that quercetin can inhibit degranulation in various types of mast cells, including rat peritoneal [33] and intestinal mast cells [6] , RBL-2H3 cells [34] , human mast cell lines [35,36] and human basophils [37] . A previous in vivo study indicated that the antioxidant activity of quercetin prevents docetaxel-induced testicular damage in rats.…”

Section: Discussionmentioning

confidence: 99%

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1

et al. 2016

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Aim: Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid contained in various plants, which can specifically inhibit histamine release as a mast cell stabilizer. In this study we explore whether quercetin could ameliorate paclitaxel-induced neuropathic pain and elucidated the underlying mechanisms. Methods: Quercetin inhibition on histamine release was validated in vitro by detecting histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with paclitaxel (10 μmol/L). In the in vivo experiments, rats and mice received quercetin (20, 40 mg·kg -1 ·d -1 ) for 40 and 12 d, respectively. Meanwhile, the animals were injected with paclitaxel (2 mg/kg, ip) four times on d 1, 3, 5 and 7. Heat hyperalgesia and mechanical allodynia were evaluated at the different time points. The animals were euthanized and spinal cords and dorsal root ganglions were harvested for analyzing PKCε and TRPV1 expression levels. The plasma histamine levels were assessed in rats on d 31. Results: Pretreatment with quercetin (3, 10, 30 μmol/L) dose-dependently inhibited excessive histamine release from paclitaxelstimulated RBL-2H3 cells in vitro, and quercetin administration significantly suppressed the high plasma histamine levels in paclitaxeltreated rats. Quercetin administration dose-dependently raised the thresholds for heat hyperalgesia and mechanical allodynia in paclitaxel-treated rats and mice. Furthermore, quercetin administration dose-dependently suppressed the increased expression levels of PKCε and TRPV1 in the spinal cords and DRGs of paclitaxel-treated rats and mice. Moreover, quercetin administration may inhibited the translocation of PKCε from the cytoplasm to the membrane in the spinal cord and DRG of paclitaxel-treated rats. Conclusion: Our results reveal the underlying mechanisms of paclitaxel-induced peripheral neuropathy and demonstrate the therapeutic potential of quercetin for treating this side effect.

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“…Our recent study revealed that Western diets induced mast cell recruitment in WAT and promoted diet-induced obesity and insulin resistance ( 34 ). As a mast cell stabilizer, quercetin can inhibit the mediator releases of mast cells in vitro ( 42,43 ). To test the effects of quercetin on adipose tissue mast cells in HFD-fed mice, we examined the number of mast cells in EAT ( Fig.…”

Section: Quercetin Inhibited Infl Ammatory Cell Recruitment Into Adipmentioning

confidence: 99%

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Dong¹,

Zhang²,

Zhang

et al. 2014

Journal of Lipid Research

242

167

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Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Cited by 53 publications

References 51 publications

Quercetin: A Versatile Flavonoid

Quercetin: A Versatile Flavonoid

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

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