Inhibitory Effects of Areca Nut Extract on Expression of Complement Receptors and Fc Receptors in Human Neutrophils

Lee, Ya-Yun; Lin, Ming Bin; Cheng, C.S. Agnes; Chang, Li‐Chun; Liu, Tsung Yun; Hung, Shan Ling

doi:10.1902/jop.2013.130498

Cited by 10 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, calcium hydroxide (slaked lime) was present in all the chewed products, and calcium hydroxide is a strong alkali that can irritate the oral mucosa (Dunham, Muir, & Hamner, ; Javed, Chotai, Mehmood, & Almas, ). Another common element observed in the chewing products was the areca nut, which has been demonstrated to alter gingival keratinocytes and fibroblasts (Chang et al., ; Jeng et al., ) and modify the antimicrobial function of neutrophils (Lee et al., ). Furthermore, the effect of tobacco used locally (chewed tobacco) causes hyperaemia in the gingiva (Mavropoulos, Aars, & Brodin, ) and increases the levels of periodontitis and gingival bleeding (Amarasena et al., , ).…”

Section: Discussionmentioning

confidence: 99%

Betel and tobacco chewing habit and its relation to risk factors for periodontal disease

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Betel and tobacco chewing habit and its relation to risk factors for periodontal disease

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A reduction in the dendritic cell (DC) population in pre-malignant and malignant oral lesions with higher grades ( Pellicioli et al, 2017 ), may promote malignancy through immune evasion. Several studies have shown the downregulation of immune response among those who chew areca nut ( Wang et al, 2011 ; Wang et al, 2012 ; Chang et al, 2014 ; Lee et al, 2014 ). Areca nut extract (ANE) inhibits the differentiation and function of DCs ( Wang et al, 2012 ; Lee et al, 2014 ).…”

Section: Capsaicin As An Anticarcinogenic Agentmentioning

confidence: 99%

“…Several studies have shown the downregulation of immune response among those who chew areca nut ( Wang et al, 2011 ; Wang et al, 2012 ; Chang et al, 2014 ; Lee et al, 2014 ). Areca nut extract (ANE) inhibits the differentiation and function of DCs ( Wang et al, 2012 ; Lee et al, 2014 ). Furthermore, augmentation of myeloid-derived suppressor cells (MDSC) via continued areca nut use fosters malignancy through auxiliary downregulation of the immune response ( Dolcetti et al, 2010 ; Wang et al, 2011 ).…”

Section: Capsaicin As An Anticarcinogenic Agentmentioning

confidence: 99%

The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis

et al. 2022

View full text Add to dashboard Cite

A burning sensation on eating spicy foods purportedly supports the role of capsaicin, an active component of chili peppers, in the etiology of oral submucous fibrosis (OSF). Although the mast cell mediators and activated P2X receptors induce a constant burning sensation through an ATP-dependent mechanism, it is the activation of the transient receptor potential vanilloid 1 (TRPV-1) receptor by capsaicin that aggravates it. The molecular basis for the burning pain in OSF is thus attributable to the activation of TRPV1. There is overwhelming evidence that confirms capsaicin has more of a protective role in attenuating fibrosis and is potentially therapeutic in reversing conditions linked to collagen accumulation. The activation of TRPV-1 by capsaicin increases intracellular calcium ([Ca2+]i), upregulates AMP-activated protein kinase (AMPK) and Sirtuin-1 (SIRT-1), to enrich endothelium-dependent vasodilation via endothelial nitric oxide synthase (eNOS). The induction of vasodilation induces antifibrotic effects by alleviating hypoxia. The antifibrotic effects of capsaicin are mediated through the upregulation of antioxidant enzymes, downregulation of inflammatory genes and suppression of new collagen fibril formation. Capsaicin also demonstrates an anticarcinogenic effect by upregulating the cytotoxic T cells and downregulating regulatory T cells through the inhibition of angiogenesis and promotion of apoptosis. Judicious administration of capsaicin with an appropriate delivery mechanism may have therapeutic benefits in reducing pain sensation, rendering antifibrotic effects, and preventing the malignant transformation of OSF. This paper provides an overview of the molecular basis of capsaicin and its therapeutic application as an antifibrotic and anticarcinogenic agent for the treatment of OSF.

show abstract

“…The aqueous extract of dried ripe Areca catechu nuts reduces the levels of Fc γ Rs and CRs expression in human neutrophils and impairs the neutrophil phagocytic ability towards complement- and IgG-opsonized microspheres [ 148 ]. The combination of ascorbate (vitamin C) and tocopherol (vitamin E) inhibits ROS generation by human neutrophils stimulated via Fc γ R with IgG-opsonized Staphylococcus aureus and Fusobacterium nucleatum [ 158 ].…”

Section: The Use Of Natural Products As Therapeutic Adjuvants To Tmentioning

confidence: 99%

Fcγand Complement Receptors and Complement Proteins in Neutrophil Activation in Rheumatoid Arthritis: Contribution to Pathogenesis and Progression and Modulation by Natural Products

Paoliello-Paschoalato

Marchi

Andrade

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a highly disabling disease that affects all structures of the joint and significantly impacts on morbidity and mortality in RA patients. RA is characterized by persistent inflammation of the synovial membrane lining the joint associated with infiltration of immune cells. Eighty to 90% of the leukocytes infiltrating the synovia are neutrophils. The specific role that neutrophils play in the onset of RA is not clear, but recent studies have evidenced that they have an important participation in joint damage and disease progression through the release of proteolytic enzymes, reactive oxygen species (ROS), cytokines, and neutrophil extracellular traps, in particular during frustrated phagocytosis of immune complexes (ICs). In addition, the local and systemic activation of the complement system contributes to the pathogenesis of RA and other IC-mediated diseases. This review discusses (i) the participation of Fcγ and complement receptors in mediating the effector functions of neutrophils in RA; (ii) the contribution of the complement system and ROS-dependent and ROS-independent mechanisms to joint damage in RA; and (iii) the use of plant extracts, dietary compounds, and isolated natural compounds in the treatment of RA, focusing on modulation of the effector functions of neutrophils and the complement system activity and/or activation.

show abstract

Inhibitory Effects of Areca Nut Extract on Expression of Complement Receptors and Fc Receptors in Human Neutrophils

Cited by 10 publications

References 48 publications

Betel and tobacco chewing habit and its relation to risk factors for periodontal disease

Betel and tobacco chewing habit and its relation to risk factors for periodontal disease

The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis

Fcγand Complement Receptors and Complement Proteins in Neutrophil Activation in Rheumatoid Arthritis: Contribution to Pathogenesis and Progression and Modulation by Natural Products

Contact Info

Product

Resources

About