Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis
Amandine Jarysta,
Abigail L.D. Tadenev,
Matthew Day
et al.
Abstract:Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all GNAI proteins and included non-physiological approaches. Pertussis toxin can downregulate functionally redundant GNAI1, GNAI2, GNAI3 and GNAO proteins, but may also induce unrelated defects. Here we directly and systematically determined the role(s) of each individua… Show more
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