Inhibitory mechanism against oxidative stress of caffeic acid

Abstract

The purpose of this article is to summarize the reported antioxidant activities of a naturally abundant bioactive phenolic acid, caffeic acid (CA, 3,4-dihydroxycinnamic acid), so that new avenues for future research involving CA can be explored. CA is abundantly found in coffee, fruits, vegetables, oils, and tea. CA is among the most potential and abundantly found in nature, hydroxycinnamic acids with the potential of antioxidant behavior. Reactive oxygen species produced as a result of endogenous processes can lead to pathophysiological disturbances in the human body. Foods containing phenolic substances are a potential source for free radical scavenging; these chemicals are known as antioxidants. This review is focused on CA's structure, availability, and potential as an antioxidant along with its mode of action. A brief overview of the literature published about the prooxidant potential of caffeic acid as well as the future perspectives of caffeic acid research is described. CA can be effectively employed as a natural antioxidant in various food products such as oils.

Hydroxycinnamic acids and human health: recent advances

“…Absorption of the esterified form, chlorogenic acid (CGA), on the other hand, was shown to be three times lower . Various pharmacological activities of CaA have been reported both in vitro and in vivo , and were later summarized in several reviews . Recent in vivo studies mainly focused on neurodegenerative disease (e.g.…”

“…52 Various pharmacological activities of CaA have been reported both in vitro and in vivo, and were later summarized in several reviews. [118][119][120] Recent in vivo studies mainly focused on neurodegenerative disease (e.g. Alzeimer's), [121][122][123][124][125][126][127] obesity and diabetes, [128][129][130] skin cancer, [131][132][133] and liver 134 and kidney damage 135 (Table 4).…”

New SiO₂/Caffeic Acid Hybrid Materials: Synthesis, Spectroscopic Characterization and Bioactivity

“…potatoes, carrots, olives, coffee beans) and fruits (e.g. blueberries, apples, cider) [3][4][5]. It could be found as monomer, in esters with small organic acids, sugars and amides, or as dimer, trimer and flavonoid derivative; furthermore, it could be linked to proteins and other polymers in the cell wall [6].…”

Optimization of high ultrasound-assisted extraction (INEFU) of active components from natural materials by response HPLC-PDA analysis

“…Moreover, these compounds, found mainly in green coffee, are important and biologically active dietary polyphenols. [11]. Calamondin orange (Citrus madurensis, Citrofortunella microcarpa), which belongs to Citrus Metacitrus Pseudofortunella, ranges from tropical to subtropical areas, including China, Philippines, Central America, Japan, and Hawaii [12].…”