Initial chemotherapy for primary resectable large-cell lymphoma of the stomach

Tondini, Carlo; Balzarotti, Monica; Santoro, Armando; Zanini, M.; Fornier, M.; Giardini, Roberto; Felice, G. Di; Bozzetti, Federico; Bonadonna, G.

doi:10.1023/a:1008206329583

Cited by 38 publications

(15 citation statements)

References 4 publications

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“…There has been no report of serious adverse effects such as bleeding or perforation in chemotherapy-treated patients of intermediate and high grade non-Hodgkin lymphomas [60] . In a report from Italy, 17 patients with resectable large cell lymphoma treated primarily by chemotherapy with or without consolidation radiotherapy, only two failed in the first line therapy and 15 were free of disease at 6 years [66] . Consolidation radiotherapy might improve the efficacy of chemotherapy.…”

Section: Chemotherapymentioning

confidence: 99%

“…A prospective study from France in 1990 reported a 100% survival in patients with high-grade tumors who underwent resection and adjuvant chemotherapy. A recent series has shown the superiority of combined surgery and chemotherapy to single mode with survival rates between 86%-94% for stages IE and IIE [53,59,66] . In these series the survival rates were higher for those who had complete resection, resection was the most important variable and major determinant of prolonged complete remission [59,60] .…”

Section: Combined Therapymentioning

confidence: 99%

“…Early stages of the disease regardless of the histological grade may be controlled by chemotherapy or chemotherapy and radiotherapy with the advantage of gastric conservation and avoidance of post-operative mortality and morbidity [54,62,[65][66][67]69,74] . On the other hand, surgery is advocated as the first option with adequate control of the disease [57][58][59]61] , and occasionally with the necessity of wide resection and extensive lymph node dissection [15,78] , however, adjuvant chemotherapy is indicated to control the local and distant disease if any [75,78] .…”

Section: Combined Therapymentioning

confidence: 99%

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Primary gastric lymphoma

Al-Akwaa¹,

Siddiqui²,

Al-Mofleh³

2004

WJG

102

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AIM:The purpose of this review is to describe the various aspects of primary gastric lymphoma and the treatment options currently available. METHODS:After a systematic search of Pubmed, Medscape and MDconsult, we reviewed and retrieved literature regarding gastric lymphoma. RESULTS:Primary gastric lymphoma is rare however, the incidence of this malignancy is increasing. Chronic gastritis secondary to Helicobacter pylori (H pylori) infection has been considered a major predisposing factor for MALT lymphoma. Immune histochemical marker studies and molecular biology utilizing polymerase chain reaction have facilitated appropriate diagnosis and abolished the need for diagnostic surgical resection. Advances in imaging techniques including Magnetic Resonance Imaging (MRI) and Endoscopic Ultrasonography (EUS) have helped evaluation of tumor extension and invasion. The clinical course and prognosis of this disease is dependent on histopathological sub-type and stage at the time of diagnosis. Controversy remains regarding the best treatment for early stages of this disease. Chemotherapy, surgery and combination have been studied and shared almost comparable results with survival rate of 70-90%. However, chemotherapy possesses the advantage of preserving gastric anatomy. Radiotherapy alone has been tried and showed good results. Stage IIIE, IVE disease treatment is solely by chemotherapy and surgical resection has been a remote consideration. CONCLUSION:We conclude that methods of diagnosis and staging of the primary gastric lymphoma have dramatically improved. The modalities of treatment are many and probably chemotherapy is superior because of high success rate, preservation of stomach and tolerable complications.Al-Akwaa AM, Siddiqui N, Al-Mofleh IA. Primary gastric lymphoma.

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Section: Chemotherapymentioning

confidence: 99%

Section: Combined Therapymentioning

confidence: 99%

Section: Combined Therapymentioning

confidence: 99%

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Primary gastric lymphoma

Al-Akwaa¹,

Siddiqui²,

Al-Mofleh³

2004

WJG

102

View full text Add to dashboard Cite

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“…Small prospective studies with chemotherapy alone or combined with radiotherapy in primary resectable aggressive gastric lymphomas have also been performed (65,66) but definitive conclusions are difficult to draw because the series included few patients and they mixed chemotherapy and radiotherapy.…”

Section: Total Body Irradiation (Tbi)mentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Non-Hodgkin's Lymphoma

2003

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“…Recently, some have suggested non-operative methods such as H pylori eradication, chemotherapy, or radiotherapy as the primary therapeutic strategies instead of surgery [21,22] . Whereas in our study only 3 patients with remnant tumor in the resection margin undertook radiotherapy, Schecheter et al [23] reported the complete resolution of 17 cases of MALT lymphomas in stages I and II with radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of surgically resected primary gastric lymphoma

Kong¹,

Kim²,

Park³

et al. 2004

WJG

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AIM:To analyze the clinicopathologic characteristics of surgically resected gastric lymphoma patients. METHODS:We retrospectively analyzed 57 surgically resected gastric lymphoma patients, dividing them into 2 subgroups: Low grade MALToma (the LG group), High grade MALToma and Diffuse large B cell lymphoma (the HG group). RESULTS:The numbers of patients were: 20 in the LG group, 37 in the HG group. The diagnostic rate of gastroscopy was 34.8% at primary diagnosis and 50% including differential diagnoses. The positive rates of H pylori were similar between the 2 groups (68% vs 77%). Multiple lesions were found in 19.3%. The proportion of mucosal and submucosal lesions was 80.0%(16/20) in the LG group, and 24.3%(9/37) in the HG group (P<0.001). Lymph node invasion rates were 10.5%(2/19) in the LG group and 44.1%(15/34) in the HG group (P=0.031). The numbers of recurred patients were none in the LG group, and 8 in the HG group. By univariant analysis, group (P=0.024) and TNM stage (stage I, II vs stages III, IV, P=0.002) were found to be the significant risk factors. There was a tendency of higher recurrence rate in the subtotal gastrectomy group than in the total gastrectomy group (P=0.50). CONCLUSION:The HG groups had a more advanced stage and a higher recurrence rate than the LG group. Although there was no difference between subtotal and total gastrectomies, more careful assessments of multiplicities and radical resections with lymph node dissections seem to be needed because of multiplicity and LN invasion even in LG group.Kong SH, Kim MA, Park DJ, Lee HJ, Lee HS, Kim CW, Yang HK, Heo DS, Lee KU, Choe KJ. Clinicopathologic features of surgically resected primary gastric lymphoma.

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Initial chemotherapy for primary resectable large-cell lymphoma of the stomach

Cited by 38 publications

References 4 publications

Primary gastric lymphoma

Primary gastric lymphoma

A Systematic Overview of Radiation Therapy Effects in Non-Hodgkin's Lymphoma

Clinicopathologic features of surgically resected primary gastric lymphoma

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