Initial clinical experience with ⁶⁸Ga-DOTA-NOC prepared using ⁶⁸Ga from nanoceria-polyacrylonitrile composite sorbent-based ⁶⁸Ge/⁶⁸Ga generator and freeze-dried DOTA-NOC kits

Abstract

Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified 68Ge/68Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients. We present our initial clinical experience in 32 patients injected with 68Ga-DOTA-NOC prepared using 68Ga eluted from Bhabha Atomic Research Centre nanoceria-polyacrylonitrile sorbent-based 68Ge/68Ga generator and freeze-dried DOTA-NOC cold kits.

Development and long-term evaluation of a new 68Ge/68Ga generator based on nano-SnO2 for PET imaging

“…Cu, Fe, Ce, Al, and Mn ion levels are always < 0.1 ppm 13 – 20 . This group has recently reported the clinical experience of 32 patients who were injected with [ 68 Ga]-Ga-DOTA-NOC prepared using 68 Ga eluted from the CeO 2 -PAN sorbent-based 68 Ge/ 68 Ga generator 21 . Our research group has also developed a nano-crystalline calcined SnO 2 -based 68 Ge/ 68 Ga generator.…”