2012
DOI: 10.1016/j.nucmedbio.2011.10.012
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Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation

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Cited by 116 publications
(133 citation statements)
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“…Therefore, the referencebased quantitative method (simplified reference tissue model) with the cerebellum as a reference region may be an easier alternative method for data analysis (10,12). Although Golla et al found a good correlation between the binding potential (BP nd ) estimated in the simplified reference tissue model and the associated V T-2TCM values, here we could not always reliably estimate the BP nd parameter using same method.…”
Section: Discussionmentioning
confidence: 65%
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“…Therefore, the referencebased quantitative method (simplified reference tissue model) with the cerebellum as a reference region may be an easier alternative method for data analysis (10,12). Although Golla et al found a good correlation between the binding potential (BP nd ) estimated in the simplified reference tissue model and the associated V T-2TCM values, here we could not always reliably estimate the BP nd parameter using same method.…”
Section: Discussionmentioning
confidence: 65%
“…Recent preclinical studies (7-9) have identified 18 F-DPA-714 as a promising TSPO ligand for in vivo imaging, and 18 F-DPA-714 has been used to quantify TSPOs in healthy subjects (10) and in amyotrophic lateral sclerosis, Alzheimer, or stroke patients (11)(12)(13). In most studies, quantification was performed without arterial samples or metabolite analysis and was based either on a simplified compartmental model (the cerebellum as a reference region (10,12)) or on a cluster analysis (10,11,13).…”
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confidence: 99%
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“…In addition, [ 18 F]DPA-714 was studied in the healthy primate and displayed marked uptake in TSPOrich organs and specific binding in the brain as demonstrated using PK11195 . [ 18 F]DPA-714 has been studied recently in healthy human subjects (Arlicot et al, 2012) and is currently evaluated in phase I-II clinical trials in Alzheimer's disease and amyotrophic lateral sclerosis patients (Clinical Trials NCT01009359 and NCT00563537).…”
Section: Discussionmentioning
confidence: 99%
“…In a recent study of several animal models of brain inflammation in our institution, [ 18 (Chauveau et al, 2009 F]DPA-714, N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl) 5,7 dimethylpyrazolo[1,5a]pyrimidin-3-yl)acetamide; G6P, glucose 6-phosphate; G6PDH, glucose-6-phosphate dehydrogenase; HPLC, high-performance liquid chromatography; LC-MS, liquid chromatography-mass spectrometry; LC-MS/MS, liquid chromatography-tandem mass spectrometry; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, nicotinamide adenine dinucleotide phosphate reduced form; PET, positron emission tomography; SPE, solid-phase extraction; TSPO, 18-kDa translocator protein; VOI, volume of interest; PK11195: N-methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide; pyrimidin-3-yl]-acetamide; PBR102: 2-(6-chloro-2-(4-(3-fluoroethoxy)phenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamide; PBR111:2-(6-chloro-2-(4-(3-fluoropropoxy)phenyl)imidazo[1,2-a] pyridin-3-yl)-N,N-diethylacetamide. (Arlicot et al, 2012;Boellaard et al, 2011).…”
Section: Introductionmentioning
confidence: 99%