Initial human experience with <scp>R</scp>ubidium‐82 renal <scp>PET</scp>/<scp>CT</scp> imaging

Tahari, Abdel; Bravo, Paco E.; Rahmim, Arman; Bengel, Frank M.; Szabó, Zsolt

doi:10.1111/1754-9485.12079

Cited by 29 publications

(60 citation statements)

References 17 publications

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“…In any case, in the context of 82 Rb myocardial perfusion, though myocardium-to-lung contrast vs noise performance was observed 97 to be enhanced with respect to space-invariant modeling, it does not follow that defect detection can be necessarily enhanced, given the fact that the heart is primarily surrounded, within positron range distances, by blood and tissue all of which have nearly identical materials properties. Alternative potential exploration of this approach within noncardiac 82 Rb imaging 102 and other imaging applications remains to be thoroughly evaluated.…”

Section: Iiib1 Space-variant Modelingmentioning

confidence: 99%

Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls

2013

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In this paper, the authors review the field of resolution modeling in positron emission tomography (PET) image reconstruction, also referred to as point-spread-function modeling. The review includes theoretical analysis of the resolution modeling framework as well as an overview of various approaches in the literature. It also discusses potential advantages gained via this approach, as discussed with reference to various metrics and tasks, including lesion detection observer studies. Furthermore, attention is paid to issues arising from this approach including the pervasive problem of edge artifacts, as well as explanation and potential remedies for this phenomenon. Furthermore, the authors emphasize limitations encountered in the context of quantitative PET imaging, wherein increased intervoxel correlations due to resolution modeling can lead to significant loss of precision (reproducibility) for small regions of interest, which can be a considerable pitfall depending on the task of interest.

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Section: Iiib1 Space-variant Modelingmentioning

confidence: 99%

Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls

2013

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“…Evaluation of renal perfusion with O-15 la beled water can be done if on-site cyclotron is available for the production 46) . Rubidium-82 chloride ( 82 Rb) PET is recently suggested as a potential renal imaging agent 47) . The development of novel molecular imaging tracers with better performance for the diagnosis and management of urologic disease, which can be used safely and reliably in clinical routine, also in pediatric population, is eagerly anticipated.…”

Section: Future Prospectivementioning

confidence: 99%

Nuclear Medicine in Pediatric Urology

Jang

2015

Child Kidney Dis

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Renal scintigraphic methods, which are physiologic and minimally invasive, have played important role in the management of various renal diseases in children, providing sensitive tool for early detection of disease even before structural changes become prominent and giving valuable functional and anatomical information to aid medical decision makings in the treatment and follow-up of patients. This review article focuses on the concept and advantages of renal scintigraphy in pediatric patients with various urologic diseases.

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“…PET signals are quantitative and can be obtained in list mode and reconstructed at the desired temporal sampling rate ( 126 ). The radiopharmaceutical p[ 18 F]fluorohippurate ([ 18 F]PFH) is stable under both in vitro and in vivo conditions and its renal clearance is suppressed by the organic anion transporter blocker probenecid ( 127 ).…”

Section: Renal Injurymentioning

confidence: 99%

“…The myocardial perfusion imaging agent, Rubidium-82 chloride has only recently been introduced for imaging renal perfusion ( 126 ). The first results show that accumulation of 82 Rb in the kidneys is high and the quality of PET images is excellent (Figure 5).…”

Section: Renal Injurymentioning

confidence: 99%

Molecular Imaging of Urogenital Diseases

Cho

Szabó

2014

Seminars in Nuclear Medicine

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There is an expanding and exciting repertoire of PET imaging radiotracers for urogenital diseases, particularly in prostate cancer, renal cell cancer, and renal function. Prostate cancer is the most commonly diagnosed cancer in men. With growing therapeutics options for the treatment of metastatic and advanced prostate cancer, improved functional imaging of prostate cancer beyond the limitations of conventional computed tomography (CT) and bone scan (BS) is becoming increasingly important for both clinical management and drug development. PET radiotracers beyond 18F-Fluorodeoxyglucose (FDG) for prostate cancer include 18F-Sodium Fluoride, 11C-Choline and 18F-Fluorocholine and 11C-Acetate. Other emerging and promising PET radiotracers include a synthetic L-leucine amino acid analog (anti-18F-FACBC), dihydrotestosterone analog (18F-FDHT) and prostate specific membrane antigen (PSMA) based PET radiotracers (ex. 18F-DCFBC, 89Zr-DFO-J591, 68Ga(HBED-CC)). Larger prospective and comparison trials of these PET radiotracers are needed to establish the role of PET/CT in prostate cancer. Renal cell cancer imaging with FDG PET/CT although available can be limited, especially for detection of the primary tumor. Improved renal cell cancer detection with carbonic anhydrase IX (CAIX) based antibody (124I-girentuximab) and radioimmunotherapy targeting with 177Lu-cG250 appear promising. Evaluation of renal injury by imaging renal perfusion and function with novel PET radiotracers include p-18F-fluorohippurate (18F-PFH) and hippurate m-cyano-p-18F-fluorohippurate (18F-CNPFH) and Rubidium-82 chloride (typically used for myocardial perfusion imaging). Renal receptor imaging of the renal renin angiotensin system with a variety of selective PET radioligands are also becoming available for clinical translation.

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Initial human experience with Rubidium‐82 renal PET/CT imaging

Abstract: Non-invasive quantitative human kidney imaging with (82)Rb PET is feasible. Advantages of renal PET with (82)Rb include excellent image quality with high image resolution and contrast. (82)Rb has potential as a clinical renal imaging agent in humans.

Cited by 29 publications

References 17 publications

Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls

Resolution modeling in PET imaging: Theory, practice, benefits, and pitfalls

Nuclear Medicine in Pediatric Urology

Molecular Imaging of Urogenital Diseases

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