Initial ratings of different types of e-cigarettes and relationships between product appeal and nicotine delivery

Hájek, Peter; Przulj, Dunja; Phillips-Waller, Anna; Anderson, Rebecca J.; McRobbie, Hayden

doi:10.1007/s00213-017-4826-z

Cited by 26 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nicotine salt formulation seems to blunt sensory clues to nicotine intake. Regarding central clues, we reported earlier that smokers do not detect nicotine content of products tried for the first time very well [19]. As noted above, a repeated exposure seems necessary for smokers to dissociate conditioned and sensory effects from the central effects that are more important in driving the behaviour.…”

Section: Discussionmentioning

confidence: 85%

“…Eight of the 20 participants also took part in a previous study [9,19] where eight different EC products were tested in exactly the same manner (see below). 2 At each session, an intravenous line for blood sampling was placed in the forearm and a baseline blood sample (up to 5 ml) was taken, after which participants were asked to smoke/vape ad libitum for 5 minutes ('You can now use your cigarette/e-cigarette as much or as little as you want for 5 minutes').…”

Section: Methodsmentioning

confidence: 99%

“…Urges to smoke were rated at baseline and at 5, 10, 15 and 30 minutes, on a scale of 1 ('no urge at all') to 10 ('extreme urge'). The measure was used in our previous reports [9,19]. At the end of each session, products were evaluated as in our previous report [19].…”

Section: Methodsmentioning

confidence: 99%

“…The measure was used in our previous reports [9,19]. At the end of each session, products were evaluated as in our previous report [19]. The following questions were asked at both the cigarette and EC/JUUL sessions (rated on a scale of 1-10): 'Did it relieve your urge to smoke?'…”

Section: Methodsmentioning

confidence: 99%

“…Two were refillable products: KangerTech EVOD and variable voltage product Innokin iTaste MVP 2, set to 4.8 V (range = 3.3-5.0 V). Both of these were used with the same 20 mg/ml nicotine e-liquid (for details of this earlier study, see [9,19]).…”

Section: Study Productsmentioning

confidence: 99%

See 4 more Smart Citations

Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products

et al. 2020

Self Cite

View full text Add to dashboard Cite

Aims To assess the pharmacokinetic (PK) profile of, and users' reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential. Design Cross-over, within-subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e-cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the eliquid than the one available in the European Union. Setting Laboratory setting in the United Kingdom. Participants Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products. Measurements At each session, number of puffs taken was counted during the 5-minute product use period and blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 minutes after starting smoking/vaping and analysed for nicotine. Participants also monitored their urges to smoke and rated the products on a range of characteristics. Findings Juul's PK profile was close to the PK profile of cigarettes [maximum concentration (C max ) = 20.4 versus 19.2 ng/ml; time to maximum concentration (T max ) = 4 versus 6 minutes; area under the curve (AUC): 307.9 versus 312.6, respectively]. Compared with other EC products, Juul had shorter T max [4 minutes, (IQR = 2.5-4.0) versus 6.3 minutes, (IQR = 4.7 -8.1), P = 0.012] and higher C max (28.9 (SD = 15.6) versus 10.6 (SD = 5.5), P = 0.013) despite a lower number of puffs (12.5 (SD = 4.2) versus 17.0 (SD = 4.2), P = 0.084). Compared with other e-cigarette products, it also provided faster reduction of urges to smoke and obtained more favourable subjective ratings.Conclusion Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers to quit smoking, but it may also have a higher potential to generate regular use in non-smokers.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Study Productsmentioning

confidence: 99%

See 3 more Smart Citations

Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Nicotine delivery and user reactions to Juul EU (20 mg/ml) compared with Juul US (59 mg/ml), cigarettes and other e-cigarette products

et al. 2020

Self Cite

View full text Add to dashboard Cite

Rationale The degree to which the EU version of Juul with 20 mg/ml nicotine (Juul EU) delivers nicotine to users is likely to determine its treatment potential. Objectives To compare the pharmacokinetic profile and user ratings of Juul EU, Juul US (59 mg/ml nicotine), cigarettes and other e-cigarette (EC) products. Methods In a within-subjects crossover design, 18 vapers used, at separate sessions, their own brand cigarette (OBC), Juul US and Juul EU for 5 min ad libitum, after overnight abstinence. Seven of the participants also tested eight other EC previously. Blood samples were taken at baseline and 2, 4, 6, 8, 10 and 30 min after initiating product use. Products were rated on a range of characteristics. Results Juul EU delivered less nicotine than OBC (t(13) = −4.64 p < .001) and than Juul US (t(13) = −6.40, p < .001): AUC0 ≥ 30 77.3, 324.8 and 355.9, respectively. Maximum nicotine concentration (Cmax) was also much lower for Juul EU than Juul US (z = −3.59, p < .001): Cmax 3.8 ng/ml vs 21.1 ng/ml, respectively. Juul EU was perceived to relieve urges to smoke less than Juul US (z = −2.29, p = .022) and to provide less nicotine (z = −2.57. p = 0.010). Juul EU delivered less nicotine than refillable EC (Cmax: t(6) = 3.02, p = 0.023; AUC0 ≥ 30: z = −2.20, p = 0.028) and also less than cig-a-like EC, though the difference did not reach significance (Cmax: t(6) = 2.49, p = 0.047; AUC0 ≥ 30: z = −1.99, p = 0.046). Subjective ratings of Juul EU and other EC products were similar. Conclusions Juul EU delivers much less nicotine to users than Juul US, and also less than refillable EC products. It may thus have more limited potential to help smokers quit.

show abstract

Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors

Bagdas,

Zepei,

Harris

et al. 2024

Psychopharmacology

View full text Add to dashboard Cite

Initial ratings of different types of e-cigarettes and relationships between product appeal and nicotine delivery

Cited by 26 publications

References 25 publications

Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products

Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products

Nicotine delivery and user reactions to Juul EU (20 mg/ml) compared with Juul US (59 mg/ml), cigarettes and other e-cigarette products

Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors

Contact Info

Product

Resources

About