Initial Therapy for Acute Myocardial Infarction

Khouzam, Rami N.; Apgar, David; Phibbs, Brendan

doi:10.1378/chest.126.2.457

Cited by 11 publications

(1 citation statement)

References 10 publications

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“…Lifelong oral anticoagulation is recommended for all patients with mechanical heart valves irrespective of valve type or date of introduction and is essential for the prevention of thromboembolic events (TEs) [1,2]. However, anticoagulation therapy is also associated with an increased risk of bleeding complications [3].…”

Section: Introductionmentioning

confidence: 99%

The effects of a low international normalized ratio on thromboembolic and bleeding complications in patients with mechanical mitral valve replacement

Bal

Aydınalp

Yılmaz

et al. 2014

J Cardiothorac Surg

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BackgroundMechanical heart valve replacement has an inherent risk of thromboembolic events (TEs). Current guidelines recommend an international normalized ratio (INR) of at least 2.5 after mechanical mitral valve replacement (MVR). This study aimed to evaluate the effects of a low INR (2.0–2.5) on thromboembolic and bleeding complications in patients with mechanical MVR on warfarin therapy.MethodsOne hundred and thirty-five patients who underwent mechanical MVR were enrolled in this study. The end points of this study were defined as TEs (valve thrombosis, transient ischemic attack, stroke) and bleeding (all minor and major bleeding) complications. Patients were followed up for a mean of 39.6 months and the mean INR of the patients was calculated. After data collection, patients were divided into 3 groups according to their mean INR, as follows: group 1 (n = 34), INR <2.0; group 2 (n = 49), INR 2.0–2.5; and group 3 (n = 52), INR >2.5.ResultsA total of 22 events (10 [7.4%] thromboembolic and 12 [8.8%] bleeding events) occurred in the follow-up period. The mean INR was an independent risk factor for the development of TEs. Mean INR and neurological dysfunction were independent risk factors for the development of bleeding events. A statistically significant positive correlation was found between the log mean INR and all bleeding events, and a negative correlation was found between the log mean INR and all TEs. The total number of events was significantly lower in group 2 than in groups 1 and 3 (P = 0.036).ConclusionsThis study showed that a target INRs of 2.0–2.5 are acceptable for preventing TEs and safe in terms of bleeding complications in patients with mechanical MVR.

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Section: Introductionmentioning

confidence: 99%