2009
DOI: 10.1203/pdr.0b013e31819e4305
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Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis

Abstract: Lupus nephritis (LN) is among the main determinants of poor prognosis in systemic lupus erythematosus (SLE). The objective of this study was to 1) isolate and identify proteins contained in the LN urinary protein signature (PS) of children with SLE; 2) assess the usefulness of the PS-proteins for detecting activity of LN over time. Using surface-enhanced or matrix assisted laser desorption/ ionization time of flight mass spectrometry, the proteins contained in the LN urinary PS were identified. They were trans… Show more

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Cited by 110 publications
(112 citation statements)
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“…Four of these were albumin fragments and the other four were transferrin (TF), ␣1-acid-glycoprotein (AGP), ceruloplasmin (CP), and lipocalin-type prostaglandin d-synthetase (L-PGDS) (32). These proteins were not increased in nonrenal SLE.…”
Section: Neutrophil Gelatinase-associated Lipocalinmentioning
confidence: 99%
“…Four of these were albumin fragments and the other four were transferrin (TF), ␣1-acid-glycoprotein (AGP), ceruloplasmin (CP), and lipocalin-type prostaglandin d-synthetase (L-PGDS) (32). These proteins were not increased in nonrenal SLE.…”
Section: Neutrophil Gelatinase-associated Lipocalinmentioning
confidence: 99%
“…s-BAFF was strongly correlated with AGP, which is an acute phase reactant that act as a carrier of basic and neutrally charged lipophilic compounds and has been suggested as a useful biomarker for LN [31]. In active LN , elevated AGP is observed both in plasma and urine, where urinary levels of AGP is increased 3 months prior to the clinical diagnosis of worsening LN activity [32]. High levels of s-BAFF were also associated with low levels of apolipoprotein A1, which is a major component of the high-density lipoprotein complex (HDL).…”
Section: Discussionmentioning
confidence: 99%
“…All tested urinary proteins were significantly higher in active vs. inactive lupus nephritis or no lupus nephritis. Significant increases of urinary transferrin and α1-acid glycoprotein occurred as early as 3 months before the clinical diagnosis of worsening lupus nephritis, indicating that these proteins are biomarkers of lupus nephritis activity and may help anticipate the future course of lupus nephritis (Suzuki, Wiers et al 2009). C3, C4 levels in active SLE or renal/extrarenal involvement have been studied with contradicting results and are reviewed by Liu (Liu, Ahearn et al 2004).…”
Section: Apps and Sle Organ Involvementmentioning
confidence: 99%