Initiation of smell function in patients with congenital hyposmia

Henkin, Robert I.; Abdelmeguid, Mona; Knöppel, Alexandra B.

doi:10.1016/j.amjoto.2016.01.001

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Furthermore, those studies that concluded significant differences between patients with AN and controls only showed marginal differences. 1013,1014,[1017][1018][1019][1020][1021][1022]1025,1027,1028 The literature evaluating the impact of extremely high BMI on OF included one systematic review that concluded solid evidence for a negative correlation between individual body weight and OF. 1029 The current review summarizes all studies that measured OF in patients with extremely high BMI.…”

Section: N Related To Extremely High or Low Body Mass Index (Bmi)mentioning

confidence: 99%

“…Most studies utilized the SS threshold, discrimination, identification combination (SS‐TDI) test 1013–1024 . While older studies showed significant heterogeneity of reported results and conclusions, 1013,1014,1016–1019,1025–1028 three recently published studies 1015,1023,1024 provided further evidence that there might exist no relevant differences in OF between patients with AN and controls. Furthermore, those studies that concluded significant differences between patients with AN and controls only showed marginal differences 1013,1014,1017–1022,1025,1027,1028 …”

Section: Pathophysiologymentioning

confidence: 99%

“…937 There is some evidence that individuals with ICA and an intact olfactory pathway may demonstrate central perception of odorant stimuli on fMRI, and theophylline has been evaluated, although in a very low evidence study, to potentially have benefit for some of these individuals. [937][938][939] Most importantly, counseling on prognosis remains critical for setting expectations for individuals with ICA.…”

Section: Congenitalmentioning

confidence: 99%

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Section: N Related To Extremely High or Low Body Mass Index (Bmi)mentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Section: Congenitalmentioning

confidence: 99%

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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“…This reflects the CNS aspects of olfactory processing (Hedner, Larsson, Arnold, Zucco, & Hummel, 2010). Treatment of patients suffering from acquired and congenital hyposmia with a non‐selective PDE inhibitor (theophylline) was shown to correct smell loss in association with an increase in nasal cGMP and cAMP levels (Henkin, Abdelmeguid, & Knöppel, 2016a; Henkin, Abdelmeguid, & Knöppel, 2016b; Henkin, Schultz, & Minnick‐Poppe, 2012), which was found to be decreased in the nasal mucus of patients with olfactory dysfunction (Henkin & Velicu, 2008). Routine testing of nasal NO levels may thus provide valuable clinical information for the diagnosis of olfactory function (Landis & Lacroix, 2009).…”

Section: A Key Role For No In Modulating Neuronal Circuit Activity Involved In Physiological Behavioural and Cognitive Functions?mentioning

confidence: 99%

Nitric oxide signalling in the brain and its control of bodily functions

Chachlaki

Prévot

2019

British J Pharmacology

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Funding information Agence Nationale de la Recherche, Grant/ Award Number: ANR-17-CE16-0015-01; Fédération Hospital-Universitaire "1000 days for health"; European Genomic Institute for Diabetes; LabEx DISTALZ Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with the ability to make continual adjustments to function in response to moment-to-moment changes in physiological input. Here, we summarize the progress in the field and argue that NO-synthetizing neurons and NO signalling in the brain provide a core hub for integrating sensory-and homeostatic-related cues, control key bodily functions, and provide a potential target for new therapeutic opportunities against several neuroendocrine and behavioural abnormalities. 1 | INTRODUCTION Nitric oxide (NO), originally referred to as endothelium relaxing fac

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“…In congenital hyposmia not associated with brain malformations, oral theophylline is effective in some cases, possibly because it induces olfactory receptor growth. 119 Olfactory Bulb and Nasal Epithelium as Sources of Progenitor "Stem" Cells…”

Section: Treatment Of Anosmiamentioning

confidence: 99%

Olfactory Development, Part 1: Function, From Fetal Perception to Adult Wine-Tasting

2017

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Discrimination of odorous molecules in amniotic fluid occur after 30 weeks' gestation; fetuses exhibit differential responses to maternal diet. Olfactory reflexes enable reliable neonatal testing. Olfactory bulbs can be demonstrated reliably by MRI after 30 weeks' gestation, and their hypoplasia or aplasia also documented by late prenatal and postnatal MRI. Olfactory axons project from nasal epithelium to telencephalon before olfactory bulbs form. Fetal olfactory maturation remains incomplete at term for neuronal differentiation, synaptogenesis, myelination, and persistence of the transitory fetal ventricular recess. Immaturity does not signify nonfunction. Olfaction is the only sensory system without thalamic projection because of its own intrinsic thalamic equivalent. Diverse malformations of the olfactory bulb can be diagnosed by clinical examination, imaging, and neuropathology. Some epileptic auras might be primarily generated in the olfactory bulb. Cranial nerve 1 should be tested in all neonates and especially in patients with brain malformations, endocrinopathies, chromosomopathies, and genetic/metabolic diseases.

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Initiation of smell function in patients with congenital hyposmia

Cited by 6 publications

References 16 publications

International consensus statement on allergy and rhinology: Olfaction

International consensus statement on allergy and rhinology: Olfaction

Nitric oxide signalling in the brain and its control of bodily functions

Olfactory Development, Part 1: Function, From Fetal Perception to Adult Wine-Tasting

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