Injectable alginate hydrogels for synergistic tumor combination therapy through repolarization of tumor-associated macrophages

Xiao, Tingting; Zhu, Jianzhi; Liang, Jia; Che, Hailong; Liu, Jie; Deckers, Jeroen; Hest, Jan C. M. van; Shi, Xiangyang

doi:10.1016/j.jconrel.2022.05.049

Cited by 21 publications

(11 citation statements)

References 44 publications

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“…As discussed in this mini-review, the possibility to co-delivery multiple therapeutic agents and combine therapies offers a new dimension to this field of research. Not only hydrophilic/hydrophobic agents can be delivered at known concentration in time and space to reduce cancer cell growth, or angiogenesis [22]; also immunotherapies delivered by alginate-based hydrogels is an effective way to move forward and have more effective treatments [36,37]. Precision multi-functional alginate-based hydrogels could offer new strategies for the treatment of pathologies such as solid tumours, interdisciplinary research is required for a rapid clinical translation of the next generation alginate-based injectable systems.…”

Section: Discussionmentioning

confidence: 99%

“…Xiao et al formulated even more sophisticated smart alginatebased multifunctional hydrogels: alginate with glucose oxidase-conjugated polyacrylic acid-stabilized iron oxide nanoparticles and Toll-like receptor 7/8 agonist resiquimod (R848) was injected and hydrogels formed by ionic cross-linking with physiological Ca 2+ level within the tumour mass. This system promoted starvation strategy (catalyzed conversion of glucose into gluconic acid and hydrogen peroxide), chemodynamic therapy (as result of the first conversion) and tumor-associated macrophages repolarization (increased M1/M2 ratio), with observed tumour growth inhibition in-vivo [37]. All these (and many other studies) claim that alginatebased injectable systems have the potential to lower the administered dosage of each individual therapy, reducing adverse side effects and increased patient compliance to therapy.…”

Section: Alginate-based Injectable Systems For Local and Controlled D...mentioning

confidence: 98%

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Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents

Bai

2022

IJDDP

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Mini Review Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents Xue Bai 1，Annalisa Tirella1,2,* 1 Division of Pharmacy and Optometry, School of Health Science, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK. 2 BIOtech-Center for Biomedical Technologies, Department of Industrial Engineering, University of Trento, Via delle Regole 101, Trento 38123, Italy. * Correspondence: annalisa.tirella@unitn.it , annalisa.tirella@manchester.ac.uk (Annalisa Tirella). Received: 13 November 2022 Accepted: 15 November 2022 Published: 21 December 2022 Abstract: Hydrogels are water-based polymeric three-dimensional network with advantageous properties for the delivery of bioactive components, ranging from small therapeutic agents to therapeutic cells. Natural-based hydrogels have great potential as delivery vehicles for the local controlled release of therapeutic agents at the target site. Injectable hydrogels are designed to load therapeutic agents by simple mixing within the polymer solutions, as well as use nanoparticles able to respond to specific external conditions, such as temperature and pH. Herein, we present an overview of the properties of natural injectable hydrogels and recent developments for their use to control the local release of therapeutic agents; as well as strategies to crosslink in-situ multifunctional injectable hydrogels that act as therapeutical depot system. The mini review focuses on alginate-based injectable hydrogels as controlled drug delivery systems, presenting advantages and challenges of their application in cancer therapy

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Section: Discussionmentioning

confidence: 99%

Section: Alginate-based Injectable Systems For Local and Controlled D...mentioning

confidence: 98%

Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents

Bai

2022

IJDDP

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“…[20][21][22][23][24] Repolarization of M2 to M1 macrophages or inhibition of M2 macrophages are typical therapeutic strategies for cancer treatment. [24][25][26][27][28][29][30] However, there are two main challenges in successfully utilizing macrophages for immunotherapy. Macrophage colony-stimulating factor (M-CSF) is constitutively produced by tumor cells.…”

Section: Doi: 101002/adma202208059mentioning

confidence: 99%

X‐ray‐Guided In Situ Genetic Engineering of Macrophages for Sustained Cancer Immunotherapy

et al. 2023

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Effective repolarization of macrophages has emerged as a promising approach for anticancer therapy. However, there are very few studies on the effect of reprogramming macrophages from M2 phenotype to M1 phenotype without reconversion while maintaining an activated M1 phenotype. Moreover, these immunomodulatory methods have serious drawbacks due to the activation of normal monocytic cells. Therefore, it remains a challenge to selectively reprogram tumor‐associated macrophages (TAMs) without systemic toxicities. Here, X‐ray‐guided and triggered remote control of a CRISPR/Cas9 genome editing system (X‐CC9) that exclusively activates therapeutic agents at tumor sites is established. Under X‐ray irradiation, X‐CC9 selectively enhances M2‐to‐M1 repolarization within the tumor microenvironment, and significantly improves antitumor efficacy with robust immune responses in two animal models. This strategy provides an ideal method for improving the safety of macrophage polarization and may constitute a promising immunotherapy strategy.

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“…Hydrogel formulation [ 15 , 16 , 17 ], capable of absorbing many fluids, is often used as a carrier of different active agents. Recently, they have been successfully used, for example, for cancer therapy [ 18 ], optic neuropathy [ 19 ], or wound healing [ 20 ]. Szekalska et al [ 21 ] prepared ALG hydrogel as a carrier of cynaroside with anti-inflammatory and anti-allergic activities.…”

Section: Alginatementioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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Injectable alginate hydrogels for synergistic tumor combination therapy through repolarization of tumor-associated macrophages

Cited by 21 publications

References 44 publications

Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents

Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents

X‐ray‐Guided In Situ Genetic Engineering of Macrophages for Sustained Cancer Immunotherapy

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

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