Injectable Allograft Adipose Matrix Supports Adipogenic Tissue Remodeling in the Nude Mouse and Human

Abstract

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A multi‐center, open‐label, pilot study of allograft adipose matrix for the correction of atrophic temples

“…These unique properties of AAM suggest that the AAM creates a functional, three‐dimensional scaffold into which adipocytes may differentiate and thrive . This theory is supported by histopathological observations of the present study as well as of a prior clinical study where the same tissue matrix (AAM) was used in the dorsum of the wrist …”

“…As stated earlier, preclinical studies show that injectable AAM retains key structural proteins as well growth factors which have been shown to support adipogenesis and angiogenesis and necessary for host fat formation . That said, the behavior of atrophy (Table 1) and fullness (Figure 1) throughout the 24‐week period may be understood by referring to the prebiopsy photographs at weeks 0 through 16 (Figure 4), weeks 0 through 24 (Figure 5), and the postbiopsy micrographs of subjects at weeks 4, 12, and 16 (Figures 7‐9, respectively).…”

“…Preclinical studies have shown that the AAM retains, through processing, critical structural proteins as well as factors reported to support fat formation when injected in the host . Beyond this, it has been suggested that an adipose‐derived architecture may promote new blood vessel formation via infiltration of endothelial cells, creating a functional, three‐dimensional scaffold into which adipocytes may differentiate and thrive …”

Design and Fabrication of an Automatable, 3D Printed Perfusion Device for Tissue Infusion and Perfusion Engineering

“…1 Typically used for repair of homologous tissue, allogeneic and xenogeneic decellularized ECMs span a plethora of therapeutic applications. Such applications include hernia repair, 2,3 breast reconstruction, 4,5 adipose regeneration, 6 dental and orthopedic bone void repair, 7,8 tendon reconstruction, 9 and wound care. 10,11 Decellularized ECM therapies continue to be investigated through clinical trials, addressing a multitude of application anatomic sites, including the trachea, heart valves, eye, and bladder among many others.…”

The role of a shelf‐ready, human‐derived, soft tissue injectable adipose matrix for facial volume correction

“…[6][7][8][9][10][11] The human-derived injectable adipose extracellular matrix (allograft adipose matrix [AAM]) contains human matrix proteins and growth factors and is available as a room-temperature-stable injectable adipose matrix. 11 The role of the AAM for correction of facial volume is explored in this review.…”