Injectable and inherently vascularizing semi-interpenetrating polymer network for delivering cells to the subcutaneous space

Mahou, Redouan; Zhang, David; Vlahos, Alexander E.; Sefton, Michael V.

doi:10.1016/j.biomaterials.2017.03.032

Cited by 42 publications

(23 citation statements)

References 34 publications

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“…Methacrylic acid (MAA)‐based materials are vascular regenerative materials that accelerate wound healing . They can be made in different forms, such as beads, porous scaffolds, hydrogels, and smooth coatings . To produce a thermoplastic coating, MAA was copolymerized with the hydrophobic isodecyl acrylate (IDA) in order to prevent the water solubility of a MAA rich polymer .…”

Section: Introductionmentioning

confidence: 99%

Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response

Coindre

Carleton

Sefton

2019

Adv Healthcare Materials

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This study reports that a methacrylic acid (MAA)‐based copolymer coating generates constructive remodeling of polypropylene (PP) surgical mesh in a subcutaneous model. This coating is non‐bioresorbable and follows the architecture of the mesh without impeding connective tissue integration. Following implantation, the tissue response is biased toward vascularization instead of fibrosis. The vessel density around the MAA mesh is double that of the uncoated mesh two weeks after implantation. This initial vasculature regresses after two weeks while mature vessels remain, suggesting an enhanced healing response. Concurrently, the MAA coating alters the foreign body response to the mesh. Fewer infiltrating cells, macrophages, and foreign body giant cells are found at the tissue–material interface three weeks after implantation. The coating also dampens inflammation, with lower expression levels of pro‐inflammatory and fibrogenic signals (e.g., Tgf‐β1, Tnf‐α, and Il1‐β) and similar expression levels of anti‐inflammatory cytokines (e.g., Il10 and Il6) compared to the uncoated mesh. Contrary to other coatings that aim to mitigate the foreign body response to PP mesh, a MAA coating does not require the addition of any biological agents to have an effect, making the coated mesh an attractive candidate for soft tissue repair.

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Section: Introductionmentioning

confidence: 99%

Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response

Coindre

Carleton

Sefton

2019

Adv Healthcare Materials

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“…Scaffold size, mechanical stability, and diffusion distances affect the choice further. Among the in vivo studies included (n = 91) the ISC/scaffold construct was transplanted into subcutaneous locations (n = 31), 27,51,69,92–94,112,115,120,133,135,145,147,156,157,171,212–225 the peritoneal cavity (n = 19), 18,26,56,63,65–68,101,134,135,173,195,226–232 an omental pouch (n = 14), 57,59,81,118,119,163,174,225,233–238 the renal capsule (n = 18), 54,…”

Section: Resultsmentioning

confidence: 99%

“…One simple and low-risk implantation method is the subcutaneous injection of a cell-containing scaffold–hydrogel. 157,213 The combination of a transient cell-containing hydrogel that can be reloaded on demand and a permanent scaffold made out of a mechanical stable synthetic polymer was described as an important step in the direction of long-term function. 51 However, because the vascular density is poor, several strategies have been used to induce the vascularization that is necessary for survival of the ISC.…”

Section: Resultsmentioning

confidence: 99%

“…Scaffold size, mechanical stability, and diffusion distances affect the choice further. Among the in vivo studies included (n = 91) the ISC/scaffold construct was transplanted into subcutaneous locations (n = 31), 27,51,69,[92][93][94]112,115,120,133,135,145,147,156,157,171,[212][213][214][215][216][217][218][219][220][221][222][223][224][225] the peritoneal cavity (n = 19), 18,26,56,63,[65][66][67][68]101,134,135,173,195,[226][227][228][229][230][231]…”

Section: Transplantation Sitementioning

confidence: 99%

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The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells

et al. 2019

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A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit. This is the first systematic review that provides an overview of scaffold materials and techniques for insulin-secreting cells or cells to be differentiated into insulin-secreting cells. An electronic literature survey was conducted in PubMed/MEDLINE and Web of Science, limited to the past 10 years. A total of 197 articles investigating 60 different materials met the inclusion criteria. The extracted data on materials, cell types, study design, and transplantation sites were plotted into two evidence gap maps. Integral parts of the tissue engineering network such as fabrication technique, extracellular matrix, vascularization, immunoprotection, suitable transplantation sites, and the use of stem cells are highlighted. This systematic review provides an evidence-based structure for future studies. Accumulating evidence shows that scaffold-based tissue engineering can enhance the viability and function or differentiation of insulin-secreting cells both in vitro and in vivo.

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“…13 Advantages of using semi-IPNs include generation of hydrogel matrices with controllable physical characteristics, more rigid and tougher mechanical properties, and more efficient drug loading compared to single network hydrogels. 14 Semi-IPNs can be used as implantable biomaterials, designed to generate a specific response, 15 as observed by Mahou et al 16 They studied a semi-IPN of a vinyl sulfone-terminated poly(ethylene glycol) (PEG) and a sodium polymethacrylate that allowed a host vascular response and subcutaneous cell delivery. These materials are an alternative choice as controlled drug release therapies, for example, Farahani et al 17 used a closedloop insulin delivery system for type I diabetic patients through a glucose responsive semi-IPN.…”

Section: Introductionmentioning

confidence: 99%

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

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Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

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Injectable and inherently vascularizing semi-interpenetrating polymer network for delivering cells to the subcutaneous space

Cited by 42 publications

References 34 publications

Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response

Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response

The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

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