Injectable and Self‐Healing Hydrogel with Anti‐Bacterial and Anti‐Inflammatory Properties for Acute Bacterial Rhinosinusitis with Micro Invasive Treatment

Abstract

Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS). However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. In this study, a new polyethylene glycol hydrogel (PEG-H) treatment model is developed to achieve sustained release of drugs at the locality while avoiding those adverse effects. The PEG-H is composed of 4-arm-PEG-SH and silver ions through a high affinity and dynamic reversible coordination bond between the thiol and silver ion. In the initial test, PEG-H is loaded with Clarithromycin (CAM-Lips@Hydrogel) or Clarithromycin and Budesonide liposomes (CAM+BUD-Lips@Hydrogel). The results show that PEG-H maintains the characteristics of self-healing, biodegradability, moderate swelling rate, injectibility and sustained drug release. In in vivo studies, the hydrogel is injected into the maxillary sinus of ABRS rabbit models. In both a single or combined load, the hydrogel not only plays an effective role as an anti-bacterial, but also inhibits inflammatory response of local sinus mucosa. In addition, no other side effects are observed in the ABRS rabbit model through behavioral observation and drug sensitivity tests. Therefore, the injectable self-healing hydrogel with anti-bacterial and anti-inflammatory properties provides a new micro invasive therapeutic method for the clinical treatment of ABRS.

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

“…Therefore, this is also a good model reference for bone repair after maxillofacial tumour treatment. In addition to these materials, hydrogels with multiple functions (including anti-inflammatory effects 132 , antibacterial effects 133 , tumour treatment 134 , tissue repair 135 , etc.) have long been applied, and injectable hydrogels have to potential to reach the targeted area without surgical harm.…”

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

“…The hydrogel is formed through a high affinity and dynamic reversible coordination bond between the thiol group of 4-arm-PEG-SH and silver ions. Moreover, in vivo studies indicate that the hydrogels not only play an effective role as an anti-bacterial, but also inhibits the inflammatory response of local sinus mucosa both in a single or combined load [158].…”

Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo

“…Chen et al proposed an injectable self-healing PEG thiolated hydrogel for sustained release clarithromycin (CAM) and budesonide (BUD) in rabbit models of acute bacterial rhinosinusitis (ABRS) with Staphylococcus Pneumonia , which during two weeks indicated a therapeutic effect. The injectable self-healing capability PEG hydrogel depends on the high affinity, and reversible binding between sulfhydryl groups and silver ions give rise to control release drugs without adverse side-effects as well as inhibition inflammatory responses [ 117 ]. Additionally, injectable smart hydrogels based on poly (ε-caprolactone- co -lactide)ester-functionalized hyaluronic acid (HA-PCLA) for delivery immunomodulatory factor (OVA expressing plasmid, pOVA) could induce production antibody and effective inhibition of human lung carcinoma in vivo [ 118 ].…”

“…Ionic interaction HPMC-C12/PEG-PLA COVID-19 vaccine for sustained release antigen RBD [113] Ionic interaction HTCC hydrogel/split antigen H5N1 influenza vaccine for sustained release H5N1 antigen [114] Ionic interaction CAM@Hydrogel/silver Antibacterial and anti-inflammatory properties [117] Imine bond HA-PCLA Delivery of pOVA to inhibit human lung carcinoma [118] 2.6. Injectable Hydrogel Used for Wound Healing Applications…”