Injectable and ultra-compressible shape-memory mushroom: Highly aligned microtubules for ultra-fast blood absorption and hemostasis

Fan, Shangchun; Wu, Xiaozhuo; Fang, Zilong; Yang, Ganghua; Yang, Jin; Zhong, Wen; Luo, Jun; Xing, Malcolm; Wan, Wenbing

doi:10.1016/j.cej.2022.140554

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…In addition, we performed an in vitro hemolysis assay to further verify the biocompatibility of MB/BG@LG. The findings demonstrated that less than 5% [ 47 ] of all groups experienced hemolysis ( Fig. 5 d).…”

Section: Resultsmentioning

confidence: 96%

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Chen

Dai

Tian

et al. 2023

Materials Today Bio

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Section: Resultsmentioning

confidence: 96%

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Chen

Dai

Tian

et al. 2023

Materials Today Bio

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“…This structure endows the foam with allotropic mechanism and oriented fluid flow. The concentration of the precursor and freezing temperature were two primary factors determining the wall thickness and channel width/pore size [ 4 ]. For collagen, a concentration-dependent relationship was observed for the channel width.…”

Section: Resultsmentioning

confidence: 99%

“…Efficient fluid concentration, reabsorption, and waste excretion are achieved through several parallel-aligned ducts exposed to gradient tissue osmotic pressure. Compared to isotropic foams with random pores, aligned materials with lower tortuosity have a stronger capillary effect as well as a lower liquid flow resistance, which increases the liquid absorbing speed [ 4 ]. This is particularly true for viscous liquids, such as tissue fluids or blood.…”

Section: Introductionmentioning

confidence: 99%

Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

Yang,

Jia,

Hua

et al. 2024

Bioactive Materials

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“…The in vitro mineralization studies involved immersing PCL-MC and PCL-MMC samples in simulated body fluid (SBF) for different durations (1, 7, 14, and 21 days) to evaluate their bioactivity. The mineralization process comprises rapid precipitation, followed by nucleation and accumulation of calcium phosphate ions on the surface of the biomaterial, alongside other chemical reactions occurring during immersion in the SBF solution, which is a crucial aspect of apatite formation. ,− …”

Section: Results and Discussionmentioning

confidence: 99%

Advancing Bioactive Material for Mandibular Bone Regeneration: Transformation of Fibrous Mat into 3D Matrix Cotton for Enhanced Shape Retention and Rapid Hemostasis

Thomas,

Rajendran,

Purushothaman

et al. 2024

ACS Biomater. Sci. Eng.

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Transformation of a fibrous mat into a three-dimensional (3D) scaffold opens up abundant innovative prospects in biomedical research, particularly for studying both soft as well as hard tissues. Electrospun nanofibers, which mimic the extracellular matrix have attracted significant attention in various studies. This research focuses on rapidly converting a fibrous mat made of polycaprolactone (PCL)/pluronic F-127 (PF-127) with different percentages of monetite calcium phosphate (MCP) into desirable 3D matrix cotton using a unique gas foaming technology. These matrix cottons possess biomimetic properties and have oriented porous structures. Using this innovative technique, various shapes of 3D matrix cotton, such as squares, hollow tubes, and other customizable forms, were successfully produced. Importantly, these 3D matrix cottons showed a consistent distribution of monetite particles with total porosity ranging from 90% to 98%. The structure of the 3D matrix cotton, its water/blood absorption capacity, the potential for causing non-hemolysis, and rapid hemostatic properties were thoroughly investigated. Additionally, periodontal cells were cultured on the 3D matrix cotton to assess their viability and morphology, revealing promising results. Furthermore, a coculture study involving NIH-3T3 and MG-63 cells on the 3D matrix cotton showed spheroidal formation within 24 h. Notably, in vitro assessments indicated that the matrix cotton containing 15% monetite (PCL-MMC15%) exhibited superior absorbent capabilities, excellent cell viability, and rapid hemostatic characteristics. Subsequently, the effectiveness of PCL-MMC15% in promoting mandibular bone regeneration was evaluated through an in vivo study on rabbits using a mandibular injury model. The results demonstrated that PCL-MMC15% facilitated the resolution of defects in the mandibular region by initiating new bone formation. Therefore, the presented 3D matrix cotton (PCL-MMC15%) shows significant promise for applications in both mandibular bone regeneration and hemostasis.

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Injectable and ultra-compressible shape-memory mushroom: Highly aligned microtubules for ultra-fast blood absorption and hemostasis

Cited by 9 publications

References 49 publications

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

Advancing Bioactive Material for Mandibular Bone Regeneration: Transformation of Fibrous Mat into 3D Matrix Cotton for Enhanced Shape Retention and Rapid Hemostasis

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