Injectable Bioactive Antioxidative One‐Component Polycitrate Hydrogel with Anti‐Inflammatory Effects for Osteoarthritis Alleviation and Cartilage Protection

Wang, Min; Li, Sihua; Zhang, Liuyang; Tian, Jing; Ma, Junping; Lei, Bo; Xu, Peng

doi:10.1002/adhm.202301953

Cited by 8 publications

(1 citation statement)

References 55 publications

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“…PIC prepolymer and PICG polymer were synthesized according to our previous report. 56 PIC prepolymer was synthesized through an esterification reaction using itaconic acid (IA, Sigma-Aldrich) and polycaprolactone diol (PCL-diol, 2000 g/mol, Acros Organics). Briefly, 1 mmol of PCL-diol was melted at 140 °C under nitrogen protection for 10 min.…”

Section: Experimental Methodsmentioning

confidence: 99%

Engineering Single-Component Antibacterial Anti-inflammatory Polyitaconate-Based Hydrogel for Promoting Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing and Skin Regeneration

Wang,

Li,

Tian

et al. 2023

ACS Nano

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Hydrogel wound dressings play a crucial role in promoting the healing of drug-resistant bacterially infected wounds. However, their clinical application often faces challenges such as the use of numerous components, a complicated preparation process, and insufficient biological activity. Itaconic acid, known for its excellent biological and reaction activities, has not been extensively studied for the preparation of itaconic acidbased hydrogels and their application in infected wound healing. Therefore, there is a need to develop a multifunctional singlecomponent itaconic acid-based hydrogel that is easy to synthesize and holds promising prospects for clinical use in promoting the healing of infected wounds. In this study, we present a singlecomponent polyitaconate-based hydrogel (PICGI) with antibacterial, anti-inflammatory, and biological activity. The PICGI hydrogel demonstrates great potential in promoting healing of infected wounds and skin regeneration. It exhibits desirable thermosensitive, injectable, and adhesive properties, as well as broad-spectrum antibacterial activity and anti-inflammatory effects. Furthermore, the PICGI hydrogel is biocompatible and significantly enhances the migration and tube formation of endothelial cells. In the case of drug-resistant bacterially infected wounds, the PICGI hydrogel effectively inhibits bacterial infection and inflammation, promotes angiogenesis, and facilitates collagen deposition, thereby accelerating the healing and regeneration of the skin. This study highlights the promising application of the PICGI hydrogel as a single-component hydrogel in tissue repair associated with bacterial infection and inflammation. Moreover, the simplicity of its components, convenient preparation process, and sufficient biological activity make the PICGI hydrogel highly suitable for promotion and clinical application.

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Section: Experimental Methodsmentioning

confidence: 99%

Engineering Single-Component Antibacterial Anti-inflammatory Polyitaconate-Based Hydrogel for Promoting Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing and Skin Regeneration

Wang,

Li,

Tian

et al. 2023

ACS Nano

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View full text Add to dashboard Cite

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Research Progress in Hydrogels for Cartilage Organoids

Li,

Sheng,

et al. 2024

Adv Healthcare Materials

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The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special cartilage tissue created using tissue engineering techniques outside the body. These engineered organoids tissues provide models that simulate the complex biological functions of cartilage, opening new possibilities for cartilage regenerative medicine and treatment strategies. However, it is crucial to establish suitable matrix scaffolds for the cultivation of CORGs. In recent years, utilizing hydrogel to culture stem cells and induce their differentiation into chondrocytes has emerged as a promising method for the in vitro construction of CORGs. In this review, we summarize the methods for establishing CORGs and provide an overview of the advantages and limitations of using matrigel in the cultivation of such organoids. Furthermore, we discuss the importance of cartilage tissue extracellular matrix (ECM) and alternative hydrogel substitutes for Matrigel, such as alginate, peptides, silk fibroin, and DNA derivatives, and outline the pros and cons of using these hydrogels for the cultivation of CORGs. Finally, we discuss the challenges and future directions in hydrogel research for CORGs. It is our hope that this article provides valuable references for the design and development of hydrogels for CORGs.This article is protected by copyright. All rights reserved

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Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

Liao,

Zhu,

Zou

et al. 2024

Adv Healthcare Materials

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Osteoarthritis (OA) is an inflammatory and progressive joint disease characterized by angiogenesis‐mediated sustained, chronic, and low‐grade synovitis. Anti‐angiogenesis is emerging as a strategy for attenuating OA progression, but is often compromised by poor targeted drug delivery and immune clearance. Recent studies have identified macrophages formed a “protective barrier” in the lining layer (LL) of synovium, which blocked the communication of joint cavity and sublining layer (SL) of synovium. Inspired by natural mimicry, macrophage membrane‐camouflaged drug delivery is explored to avoid immune clearance. Based on the single cell RNA sequencing, the CD34+ synovial cells are identified as “sentinel cells” for synovium angiogenesis. Consequently, CD34 antibody‐modified macrophage membrane is constructed to target new angiogenesis. Hence, a biomimetic multi‐layered nanoparticle (NP) is developed that incorporates axitinib‐loaded poly(lactic‐co‐glycolic) acid (PLGA) with CD34 antibody modified macrophage membrane (Atb@NP@Raw@CD34) to specifically deliver axitinib (Atb) to the SL and sustain inhibiting angiogenesis without immune elimination. It is found that the Atb@NP@Raw@CD34 can pass through macrophage “barrier”, specifically targeting CD34+ cells, continuously releasing Atb and anti‐angiogenesis in OA synovitis. Furthermore, in vivo data demonstrated that Atb@NP@Raw@CD34 can attenuate joint degeneration by inhibiting synovium angiogenesis‐mediated synovitis. In conclusion, local injection of Atb@NP@Raw@CD34 presents a promising approach for clinically impeding OA progression.

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Injectable Bioactive Antioxidative One‐Component Polycitrate Hydrogel with Anti‐Inflammatory Effects for Osteoarthritis Alleviation and Cartilage Protection

Cited by 8 publications

References 55 publications

Engineering Single-Component Antibacterial Anti-inflammatory Polyitaconate-Based Hydrogel for Promoting Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing and Skin Regeneration

Engineering Single-Component Antibacterial Anti-inflammatory Polyitaconate-Based Hydrogel for Promoting Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing and Skin Regeneration

Research Progress in Hydrogels for Cartilage Organoids

Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

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