Injectable catechin-based supramolecular hydrogel for highly efficient application in HPV-associated OSCC

Lei, Shangxue; Hu, Xiaopei; Song, Shaojuan; Zhang, Yuting; Zhao, Hang; Xu, Xiaoping; Dan, Hongxia

doi:10.1039/d2tb01938h

Cited by 8 publications

(2 citation statements)

References 43 publications

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“…Subsequently, the cumulative release of TA/Cu 2+ NPs was calculated utilizing the standard curve . At the same time, the extracted solution was centrifuged, the supernatant was obtained, and the content of copper ion was determined by inductively coupled plasma-atomic emission spectrometry (ICP-AES). , …”

Section: Experimental Methodsmentioning

confidence: 99%

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Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

Zhang,

Chen,

et al. 2023

ACS Appl. Nano Mater.

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It is often difficult to close and repair irregular wounds such as gums with traditional dressings that have a fixed shape, while injectable hydrogels that can be molded in situ offer tremendous advantages in treating complex, large wounds and can better seal or fill a variety of irregular wounds. While the majority of injectable hydrogels developed in current research have poor mechanical properties and biocompatibility and obstacles to clinical applications, this paper reports an injectable hydrogel that can be molded in situ with appropriate mechanical properties, excellent biocompatibility, and antibacterial activity. Under UV irradiation, a methacrylate-gelatin/poly(vinyl alcohol) loaded with copper ion cross-linked tannic acid nanoparticle (GelMA/PVA-TA/Cu2+NPs) precursor solution could rapidly gel within 45 s and adhere stably to the wound tissue by topological adhesion and hydrogen bonding. Through hydrogen bonding and physical entanglement, TA/Cu2+NPs are anchored in the GelMA/PVA interpenetrating network to form the GelMA/PVA-TA/Cu2+NPs composite hydrogel. This injectable hydrogel, which can quickly achieve photocurable in situ molding, can not only achieve closure and repair of irregular wounds but also has appropriate swelling characteristics, absorbing tissue exudate and blocking bacteria, while providing a good moist environment for wounds and continuously promoting wound healing. Cytotoxicity tests and wound healing experiments have shown that GelMA/PVA-TA/Cu2+NPs injectable hydrogels have good biocompatibility and wound closure and repair ability and have promising applications in the treatment of irregularly wounded orifices.

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Section: Experimental Methodsmentioning

confidence: 99%

“…34 At the same time, the extracted solution was centrifuged, the supernatant was obtained, and the content of copper ion was determined by inductively coupled plasma-atomic emission spectrometry (ICP-AES). 35,36 2.10. Antibacterial Experiment.…”

Section: Rheological Properties Of Hydrogelsmentioning

confidence: 99%

Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

Zhang,

Chen,

et al. 2023

ACS Appl. Nano Mater.

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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Guo,

Luo,

et al. 2024

Advanced Science

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Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties in preparation, side effects, and clinical translation. Recently, significant progress has been achieved in terms of direct self‐assembly of natural products from herbal medicine (NPHM), an important source for novel medications, resulting in a wide range of bioactive supramolecular materials including gels, and nanoparticles. The NPHM‐based supramolecular bioactive materials are produced from renewable resources, are simple to prepare, and have demonstrated multi‐functionality including slow‐release, smart‐responsive release, and especially possess powerful biological effects to treat various diseases. In this review, NPHM‐based supramolecular bioactive materials have been revealed as an emerging, revolutionary, and promising strategy. The development, advantages, and limitations of NPHM, as well as the advantageous position of NPHM‐based materials, are first reviewed. Subsequently, a systematic and comprehensive analysis of the self‐assembly strategies specific to seven major classes of NPHM is highlighted. Insights into the influence of NPHM structural features on the formation of supramolecular materials are also provided. Finally, the drivers and preparations are summarized, emphasizing the biomedical applications, future scientific challenges, and opportunities, with the hope of igniting inspiration for future research and applications.

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Dynamic boronate esters cross-linked guanosine hydrogels: A promising biomaterial for emergent applications

Ghosh

Das

2023

Coordination Chemistry Reviews

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Injectable catechin-based supramolecular hydrogel for highly efficient application in HPV-associated OSCC

Abstract: Catechins are a group of natural polyphenols extracted from green tea. Notably, it has been proven to have excellent anti-HPV and anti-tumour properties and to be effective against some HPV-related...

Cited by 8 publications

References 43 publications

Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Dynamic boronate esters cross-linked guanosine hydrogels: A promising biomaterial for emergent applications

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