Injectable Chitosan Hydrogels Doped with 2D Peptide Nanosheet‐Drug Conjugates for Glutathione‐Responsive Sustained Drug Delivery

Luan, Xin; Hu, Huiqiang; Zhu, Danzhu; He, Peng; Sun, Zhengang; Xi, Yongming; Wei, Gang

doi:10.1002/chem.202400021

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…This work was further explored for the development of a 2D peptide nanoplatform-based smart drug delivery system. 65 Cyclic dipeptides (CDPs) or 2,5-diketopiperazines are the simplest cyclic peptides that exhibit stereochemical rigidity, 5a). Molecular assembly of CDPs, LL-Phg (41) and LD-Phg (42) (Phg = phenyl glycine), LL-Ala (43), and LD-Ala (44), showed 2D architectural features.…”

Section: D Architectures By Programmable Fabrication Strategiesmentioning

confidence: 99%

“…Another Fmoc-protected peptide (Fmoc-FKKGSHC, 40 ) assembled to form 2D peptide nanosheets (PNSs) with uniform thickness of ∼4 nm (Figure n–p). This work was further explored for the development of a 2D peptide nanoplatform-based smart drug delivery system …”

Section: D Architectures By Programmable Fabrication Strategiesmentioning

confidence: 99%

“…Copyright 2017, 2020, and 2016, respectively, American Chemical Society. Panels (m) and (n–q) were adapted with permission from ref and ref , respectively. Copyright 2024 and 2024, respectively, Wiley-VCH.…”

Section: D Architectures By Programmable Fabrication Strategiesmentioning

confidence: 99%

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Two-Dimensional Molecular Architectonics through Controlled Noncovalent Interactions: Structure, Functional Properties, and Applications

Dinda,

Konar,

Govindaraju

2024

Chem. Mater.

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Fabrication of well-defined two-dimensional (2D) architectures employing organic or organic−inorganic hybrid molecular systems through bottom-up methodologies is a challenging task. The scheme of molecular architectonics aids in fabricating tailor-made 2D architectures through the controlled molecular assembly process. In this methodology, the controlled assembly characteristics are bestowed to functional organic cores by equipping them with appropriate biomolecular auxiliaries with inherent molecular recognition properties. The derived functional building blocks seamlessly integrate into two-dimensional macro-, micro-, and nanosheet structures through subtle noncovalent molecular assembly, coassembly, and templated assembly, ultimately showcasing a range of emergent functional properties and applications across various fields such as optoelectronics, catalysis, sensing, selfcleaning, drug delivery, and tissue engineering, among others. In this Perspective, we discuss auxiliary-guided 2D assembly architectures of functional cores through molecular assembly, coassembly, hierarchical assembly, tweezer-sandwich-inclusion (TIS) assembly, templated assembly, chiral assembly, complex dynamical assembly, self-sorted assembly, and the breath figure technique (BFT)-type assembly. The resulting tailor-made 2D architectures exhibit optoelectronic, conducting, chiro-optical, mechanical, sensor, host−guest recognition, and superhydrophobic properties.

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Section: D Architectures By Programmable Fabrication Strategiesmentioning

confidence: 99%

Section: D Architectures By Programmable Fabrication Strategiesmentioning

confidence: 99%

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Two-Dimensional Molecular Architectonics through Controlled Noncovalent Interactions: Structure, Functional Properties, and Applications

Dinda,

Konar,

Govindaraju

2024

Chem. Mater.

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Injectable Self‐Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber‐Biomimetic Silver Nanoparticles

Zhang,

Gu,

et al. 2024

Macromol. Rapid Commun.

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Polymer hydrogels find extensive application in biomedicine, serving specific purposes such as drug delivery, biosensing, bioimaging, cancer therapy, tissue engineering, and others. In response to the growing threat of bacterial infections and the escalating resistance to conventional antibiotics, this research introduces a novel injectable, self‐healing antimicrobial hydrogel comprising bioactive aldolized hyaluronic acid (AHA) and quaternized chitosan (QCS). This designed QCS/AHA hydrogel incorporates self‐assembling peptide nanofibers (PNFs) and small‐sized silver nanoparticles (AgNPs) for tailored functionality. The resulting hybrid QCS/AHA/PNF/AgNPs hydrogel demonstrates impressive rheological characteristics, broad‐spectrum antimicrobial efficacy, and high biocompatibility. Notably, its antimicrobial effectiveness against Escherichia coli and S. aureus surpasses 99.9%, underscoring its potential for treating infectious wounds. Moreover, the rheological analysis confirms its excellent shear‐thinning and self‐healing properties, enabling it to conform closely to irregular wound surfaces. Furthermore, the cytotoxicity assessment reveals its compatibility with human umbilical vein endothelial cells, exhibiting no significant adverse effects. The combined attributes of this bioactive QCS/AHA/PNF/AgNPs hydrogel position it as a promising candidate for antimicrobial applications and wound healing.

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Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

Xu,

He,

et al. 2024

Macromol. Rapid Commun.

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Amphiphilic peptides have garnered significant attention due to their highly designable and self‐assembling behaviors. Self‐assembled peptides hold excellent potential in various fields such as biosensing, environmental monitoring, and drug delivery, owing to their remarkable biological, physical, and chemical properties. While nanomaterials formed by peptide self‐assembly have found widespread use in biomedical applications, the development of 2D peptide nanosheets based on the self‐assembly of amphiphilic peptides remains challenging in terms of rational design and morphology modulation. In this study, rationally designed amphiphilic peptide molecules are self‐assembled into peptide nanosheets (PNS) under specific conditions to encapsulate gold nanoparticles (AuNPs), resulting in the formation of AuNPs/PNS hybrid materials with high photothermal conversion efficiency. The findings demonstrate that 2D PNS enhances the overall photothermal therapy effect of the nanohybrid materials due to their larger hosting area for AuNPs and higher biocompatibility. The well‐designed amphiphilic peptides in this study offer insights into the structural design and functional modulation of self‐assembled molecules. In addition, the constructed biomimetic‐functional 2D inorganic/organic nanohybrid materials hold potential applications in biomedical engineering.

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Injectable Chitosan Hydrogels Doped with 2D Peptide Nanosheet‐Drug Conjugates for Glutathione‐Responsive Sustained Drug Delivery

Cited by 8 publications

References 47 publications

Two-Dimensional Molecular Architectonics through Controlled Noncovalent Interactions: Structure, Functional Properties, and Applications

Two-Dimensional Molecular Architectonics through Controlled Noncovalent Interactions: Structure, Functional Properties, and Applications

Injectable Self‐Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber‐Biomimetic Silver Nanoparticles

Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

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