“…Nevertheless, this study did not compare the efficacy of hydrogel with MTA, which is the most commonly used repair material in clinical practice, and lacked studies investigating the relevant mechanisms. 51 Figure 4 WB and IF reveal odontogenic effects of the L-(CaP-ZnP)/SA nanocomposite hydrogel. ( A and B ) Western blot and semiquantitative assessment displaying the expression of the odontogenic-related protein (Runx2) on day 7.…”
“…Nevertheless, this study did not compare the efficacy of hydrogel with MTA, which is the most commonly used repair material in clinical practice, and lacked studies investigating the relevant mechanisms. 51 Figure 4 WB and IF reveal odontogenic effects of the L-(CaP-ZnP)/SA nanocomposite hydrogel. ( A and B ) Western blot and semiquantitative assessment displaying the expression of the odontogenic-related protein (Runx2) on day 7.…”
“…First, the hydrogel can be used as a drug delivery system to deliver drugs precisely to the repair site in a sustained, metered manner [ [25] , [26] , [27] ]. Second, it can support and promote cell proliferation, differentiation, and tissue regeneration, providing favorable conditions for successful tissue engineering [ 22 , 28 , 29 ]. However, despite the potential applications of self-assembled polypeptide hydrogels for tissue engineering and wound repair, the current therapeutic results are not ideal, especially for tendon repair.…”
Effective bone defect repair has been a tough clinical challenge due to the complexity of the bone defect microenvironment. Hydrogels loaded with bone marrow mesenchymal stem cells (BMSCs) have been widely applied for bone regeneration. However, the low survival of BMSCs at the site of transplantation and lack of sufficient osteogenic induction capacity greatly limit their applications. In order to solve this puzzle, we fabricated gelatin methacryloyl (GelMA) hydrogels containing BMSCs with cerium oxide (CeO 2 ) nanoparticles via photo-cross-linking to endow the composite hydrogel with osteogenic induction ability and immune induction ability. In vitro results demonstrated that the GelMA-CeO 2 -BMSC hydrogel presented with good biocompatibility and excellent osteogenic induction ability. In addition, the GelMA-CeO 2 -BMSC hydrogel could inhibit M1 polarization and promote M2 polarization, providing a good environment for the growth and osteogenic differentiation of BMSCs. Besides, the GelMA-CeO 2 -BMSC hydrogel was transplanted into critical-sized calvarial defects, and the results further confirmed its excellent bone regeneration capacity. In conclusion, the composite hydrogel provides a perspective for bone repair due to the remarkable potential for application in bone regeneration.
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