Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid Arthritis

Chen, Hao; Tian, Bo; Fang, Xiyao; Bai, Jinyu; Ma, Qingle; Zhang, Yue; Xu, Jialu; Wang, Beilei; Fan, Qin; Fei, Ziying; Dai, Huaxing; Shan, Huajian; Gao, Xiang; Dong, Qirong; Wang, Chao; Zhou, Xiaozhong

doi:10.1021/acsbiomaterials.1c01175

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Wang et al reported that homologous erythrocytes could form the hydrogel when they were subcutaneously injected. [149] In this system, blood clot was gel-like fibrin network trapping mass of erythrocytes, which was formed by coagulation cascade process of ex vivo blood. [150] Based on deep reddish color, the fabricated gels presented photothermal conversion under irradiation of NIR laser.…”

Section: Cellular Therapeuticsmentioning

confidence: 99%

“…[151] Except for the role of drug delivery, they could recruit lots of immune cells, including B cells, macrophage, and T cells. [150] Upon implantation, erythrocyte-based gels have showed curative effective to treat rheumatoid arthritis, [149] enhance bone repair, [151] and for cancer immunotherapy and cancer vaccination. [150,152]…”

Section: Cellular Therapeuticsmentioning

confidence: 99%

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Erythrocyte‐Inspired Functional Materials for Biomedical Applications

et al. 2022

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Erythrocytes are the most abundant cells in the blood. As the results of long‐term natural selection, their specific biconcave discoid morphology and cellular composition are responsible for gaining excellent biological performance. Inspired by the intrinsic features of erythrocytes, various artificial biomaterials emerge and find broad prospects in biomedical applications such as therapeutic delivery, bioimaging, and tissue engineering. Here, a comprehensive review from the fabrication to the applications of erythrocyte‐inspired functional materials is given. After summarizing the biomaterials mimicking the biological functions of erythrocytes, the synthesis strategies of particles with erythrocyte‐inspired morphologies are presented. The emphasis is on practical biomedical applications of these bioinspired functional materials. The perspectives for the future possibilities of the advanced erythrocyte‐inspired biomaterials are also discussed. It is hoped that the summary of existing studies can inspire researchers to develop novel biomaterials; thus, accelerating the progress of these biomaterials toward clinical biomedical applications.

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Section: Cellular Therapeuticsmentioning

confidence: 99%

Section: Cellular Therapeuticsmentioning

confidence: 99%

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

et al. 2022

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“…The diterpenoid alkaloid Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plant that has been approved for the treatment of chronic pain and rheumatoid arthritis in China [ 45 ]. The effects of BLA can be explained by its action on neuronal VGSCs.…”

Section: Natural Compounds With Effects On Voltage-gated Sodium Chann...mentioning

confidence: 99%

Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels

et al. 2022

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Voltage-gated sodium and calcium channels (VGSCs and VGCCs) play an important role in the modulation of physiologically relevant processes in excitable cells that range from action potential generation to neurotransmission. Once their expression and/or function is altered in disease, specific pharmacological approaches become necessary to mitigate the negative consequences of such dysregulation. Several classes of small molecules have been developed with demonstrated effectiveness on VGSCs and VGCCs; however, off-target effects have also been described, limiting their use and spurring efforts to find more specific and safer molecules to target these channels. There are a great number of plants and herbal preparations that have been empirically used for the treatment of diseases in which VGSCs and VGCCs are involved. Some of these natural products have progressed to clinical trials, while others are under investigation for their action mechanisms on signaling pathways, including channels. In this review, we synthesize information from ~30 compounds derived from natural sources like plants and fungi and delineate their effects on VGSCs and VGCCs in human disease, particularly pain.

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“…In addition, it is also used for local anesthesia ( Chan et al, 2021 ), analgesia ( Wang et al, 2008 ), anti-inflammation ( Zheng et al, 2017 ), and sweating ( Wu et al, 2021 ; Zhang et al, 2021 ). Aconitine has shown excellent efficacy in anti-inflammation, for instance, in the treatment of rheumatoid arthritis, by regulating IL-6 and TNF-α cytokine levels and inhibiting the activation of NF-κB signaling pathway ( Chen et al, 2021 ). Currently, several animal and cellular experiments have confirmed the inhibitory effect of aconitine alkaloids on malignant tumors ( Yao et al, 2021 ; Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis

et al. 2023

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Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc. are highly valued for their medicinal properties. The roots and tubers of these herbs are commonly used to treat an array of ailments, including joint pain and tumors. The alkaloids present in them are the primary active components, with aconitine being the most notable. Aconitine has gained attention for its exceptional anti-inflammatory and analgesic properties, as well as its potential as an anti-tumor and cardiotonic agent. However, the exact process through which aconitine hinders the growth of cancerous cells and triggers their programmed cell death remains unclear. Therefore, we have undertaken a comprehensive systematic review and meta-analysis of the current research on the potential antitumor properties of aconitine.Methods: We conducted a thorough search of relevant preclinical studies in databases including PubMed, Web of Science, VIP, WanFang Data, CNKI, Embase, Cochrane Library, and National Center for Biotechnology Information (NCBI). The search was conducted up until 15 September 2022, and the data were statistically analyzed using RevMan 5.4 software. The number of tumor cell value-added, tumor cell apoptosis rate, thymus index (TI), and Bcl-2 gene expression level were the main indicators to be analyzed.Results: After applying the final inclusion criteria, a total of thirty-seven studies, comprising both in vivo and in vitro research were analyzed. The results showed that treatment with aconitine led to a significant reduction in tumor cell proliferation, a noteworthy increase in the rate of apoptosis among tumor cells, a decrease in the thymus index, and a reduction in the expression level of Bcl-2. These results suggested that aconitine could inhibit the proliferation, invasion, and migration abilities of tumor cells by regulating Bcl-2 etc., thereby enhancing the anti-tumor effects.Conclusion: In summary, our present study demonstrated that aconitine effectively reduced tumor size and volume, indicating a strong anti-tumor effect. Additionally, aconitine could increase the expression levels of caspase-3, Bax and other targets. Mechanistically, it may regulate the expression levels of Bax and Bcl-2 through the NF-κB signaling pathway, ultimately inhibiting tumor cell proliferation through autophagy.

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Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid Arthritis

Cited by 9 publications

References 39 publications

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels

Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis

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