Injectable intraocular lens using hydrogels

Yoo, Myung-Chul; Choi, Yun Jaie; Lee, J.H.; Wee, Won Ryang; Cho, C.S.

doi:10.1016/s1773-2247(07)50011-0

Cited by 12 publications

(11 citation statements)

References 32 publications

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“…The development of foldable IOLs (silicone, hydrogel, and acrylic soft lenses) allowed the implantation of the IOL through a smaller incision (3–4 mm or less). [7, 8] As a young person’s natural crystalline lens is very soft with a shear storage modulus (G') close to 200 Pa, [9–11] even ‘soft’ foldable IOLs are too stiff to allow effective accommodation.…”

Section: Introductionmentioning

confidence: 99%

Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses

et al. 2010

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The aged eye's ability to change focus (accommodation) may be restored by replacing the hardened natural lens with a soft gel. Functionalised polysiloxane macromonomers, designed for application as an injectable, in situ curable accommodating intraocular lens (A-IOL), were prepared via a twostep synthesis. Prepolymers were synthesised via ring opening polymerisation (ROP) of octamethylcyclotetrasiloxane (D 4 ) and 2,4,6,8-tetramethylcyclotetrasiloxane (D 4 H ) in toluene using trifluoromethanesulfonic acid (TfOH) as catalyst. Hexaethyldisiloxane (HEDS) was used as the end group to control the molecular weight of the prepolymers, which were then converted to macromonomers by hydrosilylation of the SiH groups with allyl methacrylate (AM) to introduce polymerisable groups. The resulting macromonomers had an injectable consistency and thus, were able to be injected into and refill the empty lens capsular bag. The macromonomers also contained a low ratio of polymerisable groups so that they may be cured on demand, in situ, under irradiation of blue light, in the presence of a photo-initiator, to form a soft polysiloxane gel (an intraocular lens) in the eye. The pre-cure viscosity and post-cure modulus of the polysiloxanes, which are crucial factors for an injectable, in situ curable A-IOL application, were controlled by adjusting the end group and D 4 H concentrations, respectively, in the ROP. The macromonomers were fully cured within 5 minutes under light irradiation, as shown by the rapid change in modulus monitored by photorheology. Ex vivo primate lens stretching experiments on an Ex Vivo Accommodation Simulator (EVAS) showed that the polysiloxane gel refilled lenses achieved over 60% of the accommodation amplitude of the natural lens. An in vivo biocompatibility study in rabbits using the lens refilling (Phaco-Ersatz) procedure demonstrated that the soft gels were biocompatible with the ocular tissue. The polysiloxane macromonomers meet the targeted optical and mechanical properties of a young natural crystalline lens and show promise as candidate materials for use as injectable, in situ curable A-IOLs for lens refilling procedures.

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Section: Introductionmentioning

confidence: 99%

Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses

et al. 2010

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“…These properties have been exploited for fabricating intraocular lenses [65,66] and artifi cial corneas [67 -69] . Hydrogels can also be used in coating for drainage tubes and stents [70 -72] , burn dressing [73 -77] , and controlling fl ow in microfl uidic devices and microelectromechanical systems (MEMS) [78,79] .…”

Section: In Medical Devicesmentioning

confidence: 99%

In the Biomedical Arena

Misra

Gil

Lowe

2008

Polymer Grafting and Crosslinking

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“…15 Poloxamer hydrogel made of linear PEO-PPO-PEO block copolymer was also investigated. 16–18 Acrylamide copolymers with pendent thiol groups were investigated by Aliyar et al. 19…”

Section: Introductionmentioning

confidence: 99%

Fast in situ enzymatic gelation of PPO-PEO block copolymer for injectable intraocular lens in vivo

Lee

Yoon

et al. 2013

J Biomater Appl

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Foldable intraocular lenses (IOLs) have been utilized to substitute natural lens of cataract patients. In this study, we developed a fast, in situ gelable hydrogel requiring no toxic agent as an injectable IOL material. A 4-armed PPO/PEO-phenol conjugate by a non-degradable linker was synthesized to form a hydrogel in situ by horseradish peroxidase. The gelation time and modulus could be controlled, ranging from 20 s to 2 min and from 1 to 43 kPa. The adhesion of human lens epithelial cells on the hydrogel was significantly reduced compared to that on commercial IOLs. The hydrogels were injected into the rabbit eyes to evaluate the in vivo biocompatibility for 8 weeks. Corneal endothelial cell loss and central corneal thickness were comparable with the common IOL implantation procedure. Histologically, the cornea and retina showed the intact structure. The change of refraction after application of pilocarpine was +0.42 D preoperatively and +0.83 D postoperatively, which may indicate the maintenance of accommodation amplitude.

show abstract

Injectable intraocular lens using hydrogels

Cited by 12 publications

References 32 publications

Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses

Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses

In the Biomedical Arena

Fast in situ enzymatic gelation of PPO-PEO block copolymer for injectable intraocular lens in vivo

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