Injectable negatively charged gelatin microsphere-based gels as hemostatic agents for intracavitary and deep wound bleeding in surgery

Li, Lin; Du, Yumin; Xiong, Yi; Ding, Zhengwen; Lv, Guoyu; Li, Hong; Liu, Tielong

doi:10.1177/0885328218807358

Cited by 20 publications

(5 citation statements)

References 37 publications

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“…The microspheres were negatively charged and the blood clotting time of the microspheres occurred within 60 s. In vivo hemostatic studies on a deep liver wound bleeding model showed a good hemostatic effect of the microspheres. The formulations are suitable for deep wound bleeding in surgery [ 128 ]. Zhu et al, prepared collagen/cellulose nanocrystals incorporated with gentamycin sulfate loaded in gelatin microsphere.…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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“…[ 125 ] Series of injectable gelatin microsphere hydrogels (GMG) were prepared for intracranial hemostasis, deep wound bleeding, and other conventional hemostasis. [ 127 ] For irregular or perforating wound, injectable hemostatic hydrogel is fluidity and might be the best choice.…”

Section: Polysaccharide Based Hemostatic Hydrogelsmentioning

confidence: 99%

Polysaccharide Based Hemostatic Strategy for Ultrarapid Hemostasis

Chen

et al. 2020

Macromolecular Bioscience

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Bleeding complications usually cause significant morbidity and mortality in civilian and military populations. In clinical application, hemostatic sponges, gauzes, hydrogel, and bandages are widely used as the traditional effective hemostatic products for hemorrhage. However, the traditional hemostatic devices or agents cannot meet the requirement for treatment of massive bleeding. Therefore, the excellent hemostatic performance of hemostatic products are of great significance for saving lives. Natural polysaccharides, as the main chemical component, have been widely used in the preparation of hemostasis due to their perfect biocompatibility and biodegradability. Polysaccharide based hemostatic products are available in variety of forms, such as, hydrogel, sponges, gauze and microspheres. The purpose of the present review is to report the research progress on polysaccharide hemostatic products and technology.

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“…For this reason, it can interact with the bleeding site to prevent bleeding. [ 129 ] In general, microspheres technology has great potential in the field of hemostasis.…”

Section: Medical Applicationsmentioning

confidence: 99%

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Zhang

Wang

et al. 2020

Macro Materials & Eng

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Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

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Injectable negatively charged gelatin microsphere-based gels as hemostatic agents for intracavitary and deep wound bleeding in surgery

Cited by 20 publications

References 37 publications

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Polysaccharide Based Hemostatic Strategy for Ultrarapid Hemostasis

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

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