Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery

Zhu, Ying; Wang, Liying; Li, Yiping; Huang, Zhewei; Luo, Shiyao; He, Yue; Han, Han; Raza, Faisal; Wu, Jun; Ge, Liang

doi:10.1039/d0bm01004a

Cited by 57 publications

(36 citation statements)

References 30 publications

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“…In the folded conformation, the resulting hairpin structures facilitate intermolecular hydrogen bonding as well as association of the hydrophobic faces, which lead to higher order self-assembly. There are several similar β-hairpin forming sequences reported and the sequences of some of these peptides are shown in Figure 2 (15–18) ( Larsen et al, 2009 ; Rughani et al, 2009 ; Li et al, 2017 ; Zhu et al, 2020 ).…”

Section: Design Principlementioning

confidence: 81%

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Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Das

2021

Front. Chem.

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Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

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Section: Design Principlementioning

confidence: 81%

“…Another interesting secondary structure, β-hairpin, is extensively exploited by Schneider et al and later by other groups( Schneider et al, 2002 ; Li et al, 2017 ; Zhu et al, 2020 ). A Type-II’ β-turn is created between two strands of periodic repeats of alternating hydrophilic and hydrophobic amino acids.…”

Section: Design Principlementioning

confidence: 99%

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Das

2021

Front. Chem.

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“…Hydrogels with other smart-responsiveness have also been investigated in several applications, such as glucose-responsiveness as potential insulin carriers [ 189 ] and magnetic-sensitive hydrogels as suitable drug delivery systems for cancer chemotherapy [ 177 ]. Moreover, significant efforts have also been focused on developing and designing dual-responsive hydrogels with enhanced properties [ 190 , 191 ]. Hoang et al have recently synthesized a pH/thermo-responsive hydrogel comprising PAAc and norbornene-functionalized chitosan (CsNb) for colon targeted drug delivery.…”

Section: Applications Of Smart Hydrogelsmentioning

confidence: 99%

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Bustamante-Torres

Romero-Fierro

Arcentales-Vera

et al. 2021

Gels

174

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Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake capacity. However, hydrogel properties are determined by the cross-linking degree and nature, the tacticity, and the crystallinity of the polymer. These biomaterials can be sorted out according to the internal structure and by their response to external factors. In this case, the internal interaction can be reversible when the internal chains are led by physicochemical interactions. These physical hydrogels can be synthesized through several techniques such as crystallization, amphiphilic copolymers, charge interactions, hydrogen bonds, stereo-complexing, and protein interactions. In contrast, the internal interaction can be irreversible through covalent cross-linking. Synthesized hydrogels by chemical interactions present a high cross-linking density and are employed using graft copolymerization, reactive functional groups, and enzymatic methods. Moreover, specific smart hydrogels have also been denoted by their external response, pH, temperature, electric, light, and enzyme. This review deeply details the type of hydrogel, either the internal structure or the external response. Furthermore, we detail some of the main applications of these hydrogels in the biomedicine field, such as drug delivery systems, scaffolds for tissue engineering, actuators, biosensors, and many other applications.

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“…Therefore, this is also a good model reference for bone repair after maxillofacial tumour treatment. In addition to these materials, hydrogels with multiple functions (including anti-inflammatory effects 132 , antibacterial effects 133 , tumour treatment 134 , tissue repair 135 , etc.) have long been applied, and injectable hydrogels have to potential to reach the targeted area without surgical harm.…”

Section: Biomaterial-mediated Antitumour/bone Repair Strategiesmentioning

confidence: 99%

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

et al. 2021

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Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

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Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery

Abstract: Traditional anti-tumor drugs still have some shortcomings, such as low solubility, poor selectivity and poor bioavailability, which decrease anti-tumor efficacy and aggravate systemic toxicity and side effects. In this paper,...

Cited by 57 publications

References 30 publications

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

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