Injectable Photocrosslinkable Nanocomposite Based on Poly(Glycerol Sebacate) Fumarate and Hydroxyapatite: Development, Biocompatibility and Bone Regeneration in A Rat Calvarial Bone Defect Model

Bodakhe, Santosh; Verma, Shalini; Garkhal, Kalpna; Samal, Sanjaya K.; Sharma, S. S.; Kumar, Neeraj

doi:10.2217/nnm.12.192

Cited by 27 publications

(26 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 The stretchability of the material was not affected by the addition of nanotubular halloysite. 42 Nanohydroxyapatite addition led to better physical characteristics with an ultimate strength of 8 MPa. The Young's modulus and resilience of 3-5 wt% composites were similar to 0.8 MPa and 494% respectively, similar to pure PGS which is desirable for soft tissue engineering applications.…”

Section: Pgs-based Compositesmentioning

confidence: 98%

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

2015

View full text Add to dashboard Cite

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.

show abstract

Section: Pgs-based Compositesmentioning

confidence: 98%

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

2015

View full text Add to dashboard Cite

show abstract

“…IBS requires suitable rheological properties to ensure bonding and cohesion of the mineral phase in situ with good cell permeability. Usually, the necessary level of viscosity is created by addition of suitable water-soluble polymers [ 92 , 251 , 564 , 824 , 825 , 826 , 827 , 828 , 829 , 830 , 831 , 832 ]. However, IBS based on hydrogels are known as well [ 833 , 834 , 835 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

“…CaPO 4 -containing IBS based on other (bio)organic hydrogels, such as gelatin [ 564 ], CMC [ 830 ], oligo(poly(ethylene glycol) fumarate) [ 828 , 829 ], chitosan + collagen [ 831 ] have been developed as well. In addition, photocrosslinkable formulations are known [ 832 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

View full text Add to dashboard Cite

The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

show abstract

“…Despite huge efforts having been invested into the development of synthetic biomaterials since 1990s, currently there are few synthetic products available for practical clinical use that can substitute the soft, mechanically functional tissues such as muscle and connective tissue . Over the past 10 years, there has been an increasing research activity towards the development and application of synthetic biodegradable polyester elastomers (e.g., PGS, poly(polyol sebacate), and polycaprolactone) as transplantable biomaterials for tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of poly(glycerol sebacate)/cellulose nanocrystals elastomeric composites

Zhou

Jiang

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

Poly(glycerol sebacate) (PGS) is one of the new elastomers used for soft tissue engineering, while improving its limited mechanical strength is the biggest challenge. In this work, a novel biodegradable elastomer composite PGS/cellulose nanocrystals (CNCs) was prepared by solution-casting method and the mechanical properties, sol-gel contents, crosslink density, and hydrophilic performance were characterized. The thermal and degradation properties of composites were also investigated. Results show that the addition of CNCs into PGS resulted a significant improvement in tensile strength and modulus, as well as the crosslink density and the hydrophilicity of PGS. When the CNCs loading reached 4 wt %, the tensile strength and modulus of the composite reached 1.5 MPa and 1.9 MPa, respectively, resulting 204% and 158% increase compared to the pure PGS. Prolonging the curing time also improved the strength of both the neat PGS and PGS/CNCs composites according to the association and shift of hydroxy peaks around 3480 cm 21 . DSC results indicate that the addition of CNCs improved both the crystallization capacity and moving capability of PGS molecular chain.

show abstract

Injectable Photocrosslinkable Nanocomposite Based on Poly(Glycerol Sebacate) Fumarate and Hydroxyapatite: Development, Biocompatibility and Bone Regeneration in A Rat Calvarial Bone Defect Model

Abstract: This injectable, biocompatible and bioactive in situ hardening composite graft was found to be suitable for load-bearing bone regeneration applications using minimally invasive surgery.

Cited by 27 publications

References 30 publications

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Preparation and characterization of poly(glycerol sebacate)/cellulose nanocrystals elastomeric composites

Contact Info

Product

Resources

About