Injectable recombinant human collagen-derived material with high cell adhesion activity limits adverse remodelling and improves pelvic floor function in pelvic floor dysfunction rats

Hu, Li; You, Shuang; Yang, Xinggang; Liu, Shuaibin; Hu, Lina

doi:10.1016/j.msec.2022.112715

Cited by 11 publications

(7 citation statements)

References 55 publications

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“…5 The rhCOLI and rhCOLIII promote human dermal fibroblasts infiltration, neovascularization, stimulating collagen synthesis and elastin production, and modulate the inflammatory healing. [16][17][18][19][20] However, the large molecular size of the recombinant collagens limits their topical application because of the innate Note: Income per month: 1: less than ¥5, 000; 2: ¥5000-10 000; 3: ¥10 000-20 000; 4: more than ¥20 000.…”

Section: Discussionmentioning

confidence: 99%

“…This can offer more consistent and biochemically identical human collagen in a factory mode 5 . The rhCOLI and rhCOLIII promote human dermal fibroblasts infiltration, neovascularization, stimulating collagen synthesis and elastin production, and modulate the inflammatory response by downregulating pro‐inflammatory cytokines (TNF‐α, IL‐1β, and IL‐6) and upregulating anti‐inflammatory cytokines (TGF‐β1), thus allowing it to withstand or resist the damaging effects of inflammation, and leading to ECM assembly and wound healing 16–20 . However, the large molecular size of the recombinant collagens limits their topical application because of the innate barrier property of the skin.…”

Section: Discussionmentioning

confidence: 99%

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Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation

Chen

Liu

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe most visible sign of facial aging is often seen in the periocular area. However, periocular rejuvenation remains challenging due to the particularity of periocular anatomic locations.AimsWe aimed to evaluate the efficacy and safety of the fractional‐ablative CO2 laser‐facilitated recombinant human collagen permeation in periocular rejuvenation.Patients/MethodsThis 3‐month prospective single‐blinded and self‐controlled trial enrolled 26 patients with periocular aging who underwent the treatments of fractional‐ablative CO2 laser along with laser‐facilitated recombinant human collagen permeation. Following the treatments, the patients were quantitatively assessed by various periocular skin aging indices before and after the treatment and monitored for any related adverse events.ResultsThe patients showed significant improvements with the periocular skin aging indices 3 months after the treatments, which were detailed with a 47.3% decrease in lower eyelid skin rhytids, a 41.4% decrease in the lower eyelid skin texture, a 35.0% decrease in the static crow's feet, a 29.3% decrease in the amount of upper eyelid laxity, and a 20.2% increase in the MRD1 as compared with baseline (p < 0.05). Moreover, total skin thickness under ultrasound was increased in both upper and lower eyelids (5.6% and 3.3%, p < 0.05, respectively). Moreover, six patients (23.1%, 6/26) had erythema for 2 weeks, and two (2/26, 7.7%) had mild hyperpigmentation for 3 months.ConclusionsFractional‐ablative CO2 laser combined with laser‐facilitated recombinant human collagen permeation can be a safe and effective treatment for periocular rejuvenation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation

Chen

Liu

et al. 2023

J of Cosmetic Dermatology

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“…[152] This can be attributed primarily to uncertainties associated with their sourcing, extraction, and preparation, as well as the challenges encountered in preserving their mechanical strength and physicochemical properties. [109,115,153] Thus, considerable scope remains for enhancing the development of these Col-based patches. He et al [109] fabricated Colbased scaffolds using Col aggregates (Col-A) and Col molecules (Col-M) (Figure 3A(i)).…”

Section: Proteinsmentioning

confidence: 99%

“…Hydrogel-based AWHPMs can also be fabricated by chemical cross-linking techniques, which yield stronger chemical bonds than physical cross-linking. [153] These techniques are frequently employed for the direct or indirect production of patches with bio-multifunctional properties. [21,189] Specifically, patches fabricated through Schiff base cross-linking (Figure 10A(i)) demonstrate good hydrocoagulability, biocompatibility, adjustability, [133] sustainability, and the ability to mimic the biological environment.…”

Section: Chemical Cross-linkingmentioning

confidence: 99%

A Review of Advanced Abdominal Wall Hernia Patch Materials

Liang,

Ding,

et al. 2023

Adv Healthcare Materials

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Tension‐free abdominal wall hernia patch materials (AWHPMs) play an important role in the repair of abdominal wall defects (AWDs), which have a recurrence rate of <1%. Nevertheless, there are still significant challenges in the development of tailored, biomimetic, and extracellular matrix (ECM)‐like AWHPMs that satisfy the clinical demands of abdominal wall repair (AWR) while effectively handling post‐operative complications associated with abdominal hernias, such as intra‐abdominal visceral adhesion and abnormal healing. This extensive review presents a comprehensive guide to the high‐end fabrication and the precise selection of these advanced AWHPMs. The review begins by briefly introducing the structures, sources, and properties of AWHPMs, and critically evaluates the advantages and disadvantages of different types of AWHPMs for AWR applications. The review subsequently summarizes and elaborates upon state‐of‐the‐art AWHPM fabrication methods and their key characteristics (e.g., mechanical, physicochemical, and biological properties in vitro/vivo). This review uses compelling examples to demonstrate that advanced AWHPMs with multiple functionalities (e.g., anti‐deformation, anti‐inflammation, anti‐adhesion, pro‐healing properties, etc.) can meet the fundamental clinical demands required to successfully repair AWDs. In particular, there have been several developments in the enhancement of biomimetic AWHPMs with multiple properties, and additional breakthroughs are expected in the near future.

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“…To date, more than ten different recombinant collagens have been shown to have a triple helix structure [14][15][16]. The retention of the recombinant collagen triple helix structure is crucial in ensuring that the material has a chemotactic function and high biological activity inherited from animal collagen [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype

Wang

Wang³

et al. 2022

J Leather Sci Eng

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Collagen made a tremendous impact in the field of regenerative medicine as a bioactive material. For decades, collagen has been used not only as a scaffolding material but also as an active component in regulating cells' biological behavior and phenotype. However, animal-derived collagen as a major source suffered from problems of immunogenicity, risk of viral infection, and the unclear relationship between bioactive sequence and function. Recombinant humanized collagen (rhCol) provided alternatives for regenerative medicine with more controllable risks. However, the characterization of rhCol and the interaction between rhCol and cells still need further investigation, including cell behavior and phenotype. The current study preliminarily demonstrated that recombinant humanized collagen type III (rhCol III) conformed to the theoretical amino acid sequence and had an advanced structure resembling bovine collagen. Furthermore, rhCol III could facilitate basal biological behaviors of human skin fibroblasts, such as adhesion, proliferation and migration. rhCol III was beneficial for some extracellular matrix-expressing cell phenotypes. The study would shed light on the mechanism research of rhCol and cell interactions and further understanding of effectiveness in tissue regeneration. Graphical abstract

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Injectable recombinant human collagen-derived material with high cell adhesion activity limits adverse remodelling and improves pelvic floor function in pelvic floor dysfunction rats

Cited by 11 publications

References 55 publications

Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation

Combination of fractional carbon dioxide laser with recombinant human collagen in periocular skin rejuvenation

A Review of Advanced Abdominal Wall Hernia Patch Materials

Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype

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