Injectable, self-healable zwitterionic cryogels with sustained microRNA - cerium oxide nanoparticle release promote accelerated wound healing

Şener, Gülsu; Hilton, Sarah A.; Osmond, Matthew J.; Zgheib, Carlos; Newsom, Jake P.; Dewberry, Lindel C.; Singh, Sushant; Sakthivel, T.; Seal, Sudipta; Liechty, Kenneth W.; Krebs, Melissa D.

doi:10.1016/j.actbio.2019.11.014

Cited by 90 publications

(60 citation statements)

References 33 publications

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“…PVA-polysaccharide gels have been proposed by crosslinking using gamma radiation. (Sekhon & Sen Gupta, 2018;Deal et al, 2020;Sener et al, 2020;Thapa et al, 2020). Clinical trials showed that such gels can be effectively used to treat burn wounds, healing impaired ulcers, leprosy and other external wounds.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from $10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be $38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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“…The use of CNPs for managing chronic wounds caused by diabetes has been promising regarding their ability to prevent infections and accelerate wound closure [ 105 ]. It has been demonstrated that the administration of varying concentrations of nanoceria-miR-146a (1, 10, 100, and 1000 ng) may be effective in treating diabetic wounds created on the dorsal skin of Db/Db mice.…”

Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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“…In Wistar rats, a two-week treatment of the wounds with 1.5% CeONP-containing dressing accomplished a remarkable closure to nearly 100% versus the sterile gauze with almost 63% wound closure [145]. The most recently published work about wound dressings has come from Sener et al's group, which fabricated a biomaterial system of zwitterionic cryogels (gels polymerized below freezing temperature conditions) loaded with CeONP-microRNA-146a (miR146a) for a better delivery method [146]. In order to avoid tough and brittle cryogels, chemical crosslinkers were removed, and, instead, the hydrogen bonding and electrostatic attractions between pendant groups of the zwitterionic polymers were used.…”

Section: Wound Healing and Skin Regenerationmentioning

confidence: 99%

“…More importantly, the accelerated wound healing was achieved in a diabetic mouse model. The diabetic mouse skin after treatment demonstrated significantly increased modulus and overall strength, meaning that the healed wounds were of less rigidity and were not sensitive to future injury [146].…”

Section: Wound Healing and Skin Regenerationmentioning

confidence: 99%

Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering

Hosseini

Mozafari

2020

Materials

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Submicron biomaterials have recently been found with a wide range of applications for biomedical purposes, mostly due to a considerable decrement in size and an increment in surface area. There have been several attempts to use innovative nanoscale biomaterials for tissue repair and tissue regeneration. One of the most significant metal oxide nanoparticles (NPs), with numerous potential uses in future medicine, is engineered cerium oxide (CeO2) nanoparticles (CeONPs), also known as nanoceria. Although many advancements have been reported so far, nanotoxicological studies suggest that the nanomaterial’s characteristics lie behind its potential toxicity. Particularly, physicochemical properties can explain the positive and negative interactions between CeONPs and biosystems at molecular levels. This review represents recent advances of CeONPs in biomedical engineering, with a special focus on tissue engineering and regenerative medicine. In addition, a summary report of the toxicity evidence on CeONPs with a view toward their biomedical applications and physicochemical properties is presented. Considering the critical role of nanoengineering in the manipulation and optimization of CeONPs, it is expected that this class of nanoengineered biomaterials plays a promising role in the future of tissue engineering and regenerative medicine.

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Injectable, self-healable zwitterionic cryogels with sustained microRNA - cerium oxide nanoparticle release promote accelerated wound healing

Cited by 90 publications

References 33 publications

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering

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