Injectable, stretchable, toughened, bioadhesive composite hydrogel for bladder injury repair

Abstract

An injectable, stretchable, toughened, bioadhesive composite hydrogel offers a new application strategy for sutureless repair and tissue regeneration of injured bladders.

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

“…For instance, Fu and colleagues developed an injectable hydrogel with methacrylated silk fibroin, GelMA and Pluronic F127 diacrylate, which was crosslinked via covalent and non-covalent bond interactions. 137 The novel hydrogel could fill arbitrarily shaped defects perfectly and transform into gel to provide stable bio-adhesive and sealing properties within 90 s after injection. It was characterized by significantly enhanced mechanical properties (including toughness, stretchability and viscoelasticity), as it provided stable support for bladder during large stress-strain encounters and cyclic stress changes.…”

Bioadhesive and Injectable Hydrogels and Their Correlation with Mesenchymal Stem Cells Differentiation for Cartilage Repair: A Mini-Review

“…Corneal patch for in situ sutureless corneal repair [37] Cephalexin NT and chitosane hydrogel Positively charged groups Antibacterial drug delivery [38] Hybrid double-network polydopamine-hyaluronic acid hydrogel -Disposable wound dressing [39] Gelatin and glycerine-based hydrogel -Site-specific drug release [40] Methacrylate gelatine + methacrylated silk fibroin + Pluronic F127 diacrylate Amine-MA and thiol-MA groups plus intermolecular non-covalent bonds Bladder injury repair [41] Table 3. An overview in recent research developments in bioadhesive and bioadhesive-injectable hydrogels in cartilage repair.…”

“…The test assesses shear strength, with cohesive failure occurring within the adhesive, while the adhesive failure depends on the adherend's interface properties [58]. It is a standardized method (ASTM F2255:2005 [59]) that research teams modify [60]; usually, the test undergoes ex vivo utilizing porcine skin [20,61], and the test could be also performed in vitro [41].…”

“…A novel injectable acacia gum (AG) hydrogel with rapid gelation, self-healing, and effective bioadhesion holds promise for future biomedical applications as a wound-healing agent carrier [77]. Lastly, a composite hydrogel designed for bladder injuries shows potential for tissue engineering and bladder tissue regeneration [41], and a Tetra-PEG hydrogel bioadhesive (SS) offers sutureless repair of GI defects with controlled inflammation and tissue regeneration [78].…”

Research progress of biomaterials and innovative technologies in urinary tissue engineering

“…Large or complex urinary injuries require surgical management and the choice of repair depends on the site of injury and timing of identification. Surgery treatment often include repairing urethral strictures or bladder damaged tissues, or repairing an abnormal bladder, and so on ( Zelivianskaia et al, 2021 ; Fu et al, 2023 ). However, the repair of urinary bladder injury is often associated with some short- and long-term complications ( Cohen et al, 2016 ).…”