Injectable zwitterionic thermosensitive hydrogels with low-protein adsorption and combined effect of photothermal-chemotherapy

Zheng, Anbi; Wu, Di; Fan, Man; Wang, Hong; Liao, Yonggui; Wang, Qin; Yang, Yingping

doi:10.1039/d0tb01763a

Cited by 32 publications

(21 citation statements)

References 51 publications

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“…In addition, polydopamine nanoparticles (PDA NPs) without directly antibacterial effect were mixed with PNS dispersion (50 mg mL −1 ) as a reference (named as PNSD). According to the photothermal performance of PDA NPs in our previous study, [ 33 ] the concentration of PDA NPs was fixed at 70 µg mL −1 . As shown in Figure S3a (Supporting Information), the heating performance of the PNSD under NIR irradiation (808 nm, 1.0 W cm −2 ) in vitro was similar to that of the PNSI (Figure 3a).…”

Section: Resultsmentioning

confidence: 99%

Injectable Thermosensitive Iodine‐Loaded Starch‐g‐poly(N‐isopropylacrylamide) Hydrogel for Cancer Photothermal Therapy and Anti‐Infection

Fan

Wang

et al. 2022

Macromol. Rapid Commun.

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Although photothermal therapy (PTT) can effectively eliminate tumors, the normal tissues near tumors are inevitably damaged by heat and infected by bacteria, which greatly limits the therapeutic effect. In this work, an injectable thermosensitive hydrogel based on iodine‐loaded starch‐g‐poly(N‐isopropylacrylamide) (PNSI) is developed to overcome this problem. FTIR, 1H NMR, and UV–vis spectra confirm the graft copolymerization of poly(N‐isopropylacrylamide) with starch and the formation of “iodine−starch” complex. Transmission electron microscope images show PNSI polymer self‐assembles into regular spherical nanogel with a size of ≈50 nm. The concentrated nanogel dispersion is a sol at room temperature and transforms to hydrogel at body temperature. Under NIR laser irradiation for 10 min, the ΔT of the nanogel dispersion approachs about 20 °C with excellent thermal stability and high cytotoxicity due to the photothermal effect of the “iodine−starch” complex. After intratumor injection, this injectable hydrogel efficiently inhibites the tumor growth under 808 nm laser irradiation. Furthermore, it can also suppress Staphylococcus aureus infection in the wound post‐PTT due to the release of iodine, which promotes wound healing. Therefore, this injectable thermosensitive “iodine−starch” composite hydrogel with advantages of good biocompatible and easy preparation possesses potential application for tumor photothermal therapy and antibacterial infection.

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Section: Resultsmentioning

confidence: 99%

Injectable Thermosensitive Iodine‐Loaded Starch‐g‐poly(N‐isopropylacrylamide) Hydrogel for Cancer Photothermal Therapy and Anti‐Infection

Fan

Wang

et al. 2022

Macromol. Rapid Commun.

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“…On the premise of keeping enough antifouling properties, other functional groups which can be used to stabilize polymer networks are also gradually introduced to enhance zwitterionic hydrogels. There are two main categories: (1) introducing hydrophobic groups/intermolecular hydrogen-bond formation moieties into zwitterionic side-chain ( Figure 5 c) [ 54 , 55 , 56 , 57 ]; (2) copolymerization of zwitterionic monomers with different functional monomers ( Figure 5 d) [ 44 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. At present, through the selection of different monomers, zwitterionic hydrogels have been able to achieve various aspects of strength and elasticity regulation to promote their application.…”

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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“…Wang et al described a polydopamine nanoparticle conjugated polyethylene glycol hydrogel that could be used for on-demand drug delivery and combined chemotherapyphotothermal therapy under near-infrared irradiation (Figure 6A) (Wang et al, 2017). Most importantly, the hydrogel had good biocompatibility and would not cause (Zheng et al, 2020). The hydrogel has anti protein adsorption and photothermal effects, and the injectable amphoteric ion thermosensitive hydrogel has the advantage of low pollution.…”

Section: Polymeric Nanomaterialsmentioning

confidence: 99%

Photothermal nanohybrid hydrogels for biomedical applications

Ding

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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In the past decades, diseases such as wound infection, cancer, bone defect and osteoarthritis have constantly threatened the public health. However, the traditional treatment has many insufficiencies, such as high cost, easy recurrence and high biological toxicity. Hydrogel is a material with three-dimensional network structure, which has a series of advantages, such as injectability, self-heal ability, easy loading and controllability of drug release, and excellent biocompatibility. Therefore, it is extensively used in drug delivery, antibacterial, anti-cancer and other fields. However, the traditional hydrogels have the single performance, and therapeutic efficacy is often rely on the drugs loaded on them to cure diseases, which cannot achieve sustainable therapeutic effect. In order to solve this problem, photothermal nano hydrogel with photothermal agent (PTA) has become an ideal material due to its excellent physical and chemical properties. Photothermal nano hydrogels used in photothermal therapy (PTT) can exploit the photothermal effect of photothermal agent to increase local temperature and control the sol-gel phase transition behavior of hydrogels, so they are widely used in drug release, photothermal sterilization, photothermal inhibition of cancer cells and enhancement of bone repair. To sum up, this paper introduces the preparation of hydrogels with photothermal nanomaterials, and discusses their applications in the fields of drug release, photothermal sterilization, photothermal cancer cell inhibition and enhanced bone repair.

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Injectable zwitterionic thermosensitive hydrogels with low-protein adsorption and combined effect of photothermal-chemotherapy

Abstract: Injectable hydrogels have been developed as biomedical materials in various fields but the biofouling on their surface limits the applications in vivo. In this work, zwitterionic structure was introduced into...

Cited by 32 publications

References 51 publications

Injectable Thermosensitive Iodine‐Loaded Starch‐g‐poly(N‐isopropylacrylamide) Hydrogel for Cancer Photothermal Therapy and Anti‐Infection

Injectable Thermosensitive Iodine‐Loaded Starch‐g‐poly(N‐isopropylacrylamide) Hydrogel for Cancer Photothermal Therapy and Anti‐Infection

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Photothermal nanohybrid hydrogels for biomedical applications

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