Inline Spectroscopy‐Based Optimization of Chemical Reactions Considering Dynamic Process Conditions

Abstract

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.The demand for sustainable energy sources, like biomass, solar energy, hydro and wind power, is connected to challenges like energy storage and fluctuating energy supply. Regarding the second challenge, industry has to evolve their existing processes from steady state processes to dynamic ones. This work is concerned with the conception of an inline spectroscopy-based optimization routine for chemical reactions under dynamic process conditions, which implements the search for a well applicable optimization algorithm. The studied reaction to reach this goal is a nitroaldol condensation.

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

“…Several in-line monitoring tools, for example, ReactIR [58][59][60][61][62] and flow based NMR [63][64][65][66] which allow for substrate specific, nonconsuming analysis, have also been developed. Other in-line techniques employing simple UV [67][68][69][70], MS [71][72][73], and Raman [74][75][76][77] analysis have also been successfully applied enabling efficient optimisation and generation of new reaction chemistry.…”

“…The use of proline tetrazole packed in a column for aldol reaction between cyclohexanone ( 65) and 2,6-dichlorobenzaldehyde (70). Conveniently, the (S)-enantioselectivity could be reversed by inversion of stereochemistry at the terminal proline moiety of the supported peptide.…”