Innate immune cell activation in symptomatic and asymptomatic atherosclerosis in humans in vivo

Bekkering, Siroon; Munckhof, Inge van den; Nielen, Tim Mj; Rutten, Joost H.W.; Graaf, Jacqueline de; Joosten, Leo A. B.; Netea, Mihai G.; Gomes, Marc E.; Riksen, N.P.

doi:10.1016/j.atherosclerosis.2016.07.077

Cited by 2 publications

(1 citation statement)

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“…Its level is upregulated as a result of proinflammatory stimuli and the tissue injury associated with atherosclerotic lesions [ 67 ]. According to one of the recent studies on inflammatory atherosclerosis pathogenesis, isolated human monocytes, via trained immunity induced by the primary stimulation of ox-LDL during secondary stimulation with agonists of toll-like TLR2 and TLR4 receptors, showed an increase in the production of proinflammatory cytokines such as TNF-alpha, interleukins -6, -8, and -18 and precisely the MCP-1 chemokine [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model

Danielewski

Gomułkiewicz

Kucharska

et al. 2023

IJMS

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Atherogenesis leads to the development of atherosclerosis, a progressive chronic disease characterized by subendothelial lipoprotein retention and endothelial impairment in the arterial wall. It develops mainly as a result of inflammation and also many other complex processes, which arise from, among others, oxidation and adhesion. Cornelian cherry (Cornus mas L.) fruits are abundant in iridoids and anthocyanins—compounds with potent antioxidant and anti-inflammatory activity. This study aimed to determine the effect of two different doses (10 mg and 50 mg per kg of body weight, respectively) of iridoid and anthocyanin-rich resin-purified Cornelian cherry extract on the markers that are important in the progress of inflammation, cell proliferation and adhesion, immune system cell infiltration, and atherosclerotic lesion development in a cholesterol-rich diet rabbit model. We used biobank blood and liver samples that were collected during the previous original experiment. We assessed the mRNA expression of MMP-1, MMP-9, IL-6, NOX, and VCAM-1 in the aorta, and the serum levels of VCAM-1, ICAM-1, CRP, PON-1, MCP-1, and PCT. The application of the Cornelian cherry extract at a dose of 50 mg/kg bw resulted in a significant reduction in MMP-1, IL-6, and NOX mRNA expression in the aorta and a decrease in VCAM-1, ICAM-1, PON-1, and PCT serum levels. The administration of a 10 mg/kg bw dose caused a significant decrease in serum ICAM-1, PON-1, and MCP-1. The results indicate the potential usefulness of the Cornelian cherry extract in the prevention or treatment of atherogenesis-related cardiovascular diseases, such as atherosclerosis or metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%