Innate immune genes in persistent mating-induced endometritis in horses

Marth, C; Firestone, Simon M.; Hanlon, D. N.; Glenton, Lisa Y.; Browning, Glenn F.; Young, Neil D.; Krekeler, Natali

doi:10.1071/rd17157

Cited by 18 publications

(36 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with other studies (Crossett, Allen, & Stewart, ; Hayes et al, ), P19/uterocalin (also known as concepticalin, equicalin and lipocalin P19) was found to be more abundant in endometrial flush fluid samples from mares in dioestrus. Studies on endometrial mRNA expression of uterocalin in mares have also indicated greater expression in dioestrus than in oestrus (Marth et al, ). Uterocalin is a P 4 ‐dependent protein that is secreted by endometrial glands both in dioestrus and early pregnancy (Crossett et al, ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A comparison of the uterine proteome of mares in oestrus and dioestrus

Maloney

Khan

Chenier

et al. 2018

Reprod Domestic Animals

View full text Add to dashboard Cite

Contents Proteomic analysis of mare uterine flush fluid provides a minimally invasive technique for studying protein changes associated with the oestrous cycle. The aim of this study was to identify differentially abundant proteins in the uterine flush fluid of mares in oestrus and dioestrus. In this study, uterine flush fluid samples were collected from eight reproductively healthy mares in either oestrus (n = 5) or dioestrus (n = 3). Proteomic analysis was performed using liquid chromatography‐tandem mass spectrometry. Of 172 proteins identified, six proteins (immunoglobulin lambda‐like polypeptide 1, haemoglobin subunit alpha, alpha‐1B‐glycoprotein, serotransferrin, apolipoprotein A‐1, and haemoglobin subunit beta) were significantly more abundant in oestrus. These proteins may contribute to the endometrial defence system through roles in inflammation, immunity or antimicrobial activity. In other species, some of these proteins have been described as immunoglobulins, negative acute phase proteins or defence agents against micro‐organisms. During dioestrus, immunoglobulin alpha‐1 chain C region‐related, complement factor I, CD 109 antigen and uterocalin, were significantly more abundant. Research in other species suggests that these four proteins contribute to the immune response through proposed immunoregulatory characteristics, complement system involvement or roles in B cell–T cell interactions. In conclusion, ten differentially abundant proteins were identified in the uterine flush fluid of mares in oestrus and dioestrus. Targeted studies on these proteins could elucidate their role in uterine defence mechanisms during the oestrous cycle in the mare.

show abstract

Section: Discussionmentioning

confidence: 99%

“…have also indicated greater expression in dioestrus than in oestrus (Marth et al, 2016(Marth et al, , 2018. Uterocalin is a P 4 -dependent protein that is secreted by endometrial glands both in dioestrus and early pregnancy (Crossett et al, 1996).…”

Section: Studies On Endometrial Mrna Expression Of Uterocalin In Maresmentioning

confidence: 99%

A comparison of the uterine proteome of mares in oestrus and dioestrus

Maloney

Khan

Chenier

et al. 2018

Reprod Domestic Animals

View full text Add to dashboard Cite

show abstract

“…Adaptive immunity responds selectively and gradually to the detection of antigens, and this is mediated by the T lymphocytes [95]. In contrast, the response to breeding is dictated by the innate immune response [28,30]. This consists of a non-specific, rapid, and transient response [96].…”

Section: Non-infectious Endometritismentioning

confidence: 99%

“…The local innate immune response is immediately activated after antigen recognition and signaling by mucosal epithelial cells in the endometrium [28,30]. The detection of foreign particles induces the activation of the innate immune system, which is the first line of defense.…”

Section: Innate Immune Response To Endometritismentioning

confidence: 99%

“…While equine endometritis has been a widely studied disease in the past 40 years and elegant reviews have been published on the subject [22][23][24][25][26][27], much progress has been made in the last decade towards the understanding of the molecular aspects involved in PBIE and pathways downor up-regulated in response to experimental induction and treatment [17,[28][29][30][31][32][33][34][35]. Therefore, this manuscript aims to revise the clinical, molecular, and microbiological aspects of the pathogenesis, diagnosis, and treatment of endometritis in mares.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

Canisso

Segabinazzi

Fedorka

2020

IJMS

105

View full text Add to dashboard Cite

Post-breeding endometritis (i.e., inflammation/infection of the endometrium), is a physiological reaction taking place in the endometrium of mares within 48 h post-breeding, aimed to clear seminal plasma, excess sperm, microorganisms, and debris from the uterine lumen in preparation for the arrival of an embryo. Mares are classified as susceptible or resistant to persistent breeding-induced endometritis (PBIE) based on their ability to clear this inflammation/infection by 48 h post-breeding. Mares susceptible to PBIE, or those with difficulty clearing infection/inflammation, have a deficient immune response and compromised physical mechanisms of defense against infection. Molecular pathways of the innate immune response known to be involved in PBIE are discussed herein. The role of the adaptive uterine immune response on PBIE remains to be elucidated in horses. Advances in the pathobiology of microbes involved in PBIE are also revised here. Traditional and non-traditional therapeutic modalities for endometritis are contrasted and described in the context of clinical and molecular aspects. In recent years, the lack of efficacy of traditional therapeutic modalities, alongside the ever-increasing incidence of antibiotic-resistant microorganisms, has enforced the development of non-traditional therapies. Novel biological products capable of modulating the endometrial inflammatory response are also discussed here as part of the non-traditional therapies for endometritis.

show abstract