Innate Immune Responses in HIV-Infection

Posch, Wilfried; Lass‐Flörl, Cornelia; Wilflingseder, Doris

doi:10.5772/24698

Cited by 3 publications

(3 citation statements)

References 144 publications

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“…The complement system is vital during viral infection and is the first barrier to manage and maintain the spread of HIV. It also aids in the clearance and neutralisation of HIV (Posch et al, 2011). When HIV-1 enters the host, it activates the complement system via its two glycoproteins, gp41 and gp120, without the need for HIV-specific antibodies and hence it becomes coated with complement fragments (Hladik and McElrath, 2008).…”

Section: The Complement System In the Duality Of Hiv Infection And Preeclampsiamentioning

confidence: 99%

“…Therefore; the virus is protected from complement-mediated lysis (Roberts et al, 2010). Additionally, it was observed that the complement system or together with dendritic cells (DCs) are involved with priming of antiviral T cell immunity, suggesting the complement system activates lysis and mediates an adaptive immune response (Posch et al, 2011).…”

Section: The Complement System In the Duality Of Hiv Infection And Preeclampsiamentioning

confidence: 99%

“…It also assists in the clearance and neutralisation of HIV (Posch et al, 2011). Adipsin is a serine protease, that activates the alternative pathway of the complement system, therefore activating the body's natural defence against pathogens .…”

Section: Declaration Of Interestmentioning

confidence: 99%

See 2 more Smart Citations

The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

David

Moodley

Naicker

2021

Arch Gynecol Obstet

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Section: The Complement System In the Duality Of Hiv Infection And Preeclampsiamentioning

confidence: 99%

Section: The Complement System In the Duality Of Hiv Infection And Preeclampsiamentioning

confidence: 99%

See 1 more Smart Citation

The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

David

Moodley

Naicker

2021

Arch Gynecol Obstet

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HIV Vaccine to Induce Cytotoxic T Cells Recognizing Conserved HIV-1/2-Epitopes Derived from the Most Frequent HLA Types of the Human Population

Somogyi¹,

Lisziewicz²

2013

Immunotherapy

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Evaluation of: Pleguezuelos O, Stoloff GA, Caparros-Wanderley W. Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation. Virol. J. 10(1), 107 (2013). AIDS vaccine development represents an unprecedented challenge in both immunogen design and delivery to induce potent and long-lasting HIV-specific immune responses, including neutralizing antibodies and cytotoxic T lymphocytes (CTL). Pleguezuelos and coworkers recognized that immunogen design must address both HIV and HLA diversity to make a global vaccine. The HIV-v synthetic polypeptide vaccine described here sets a new standard in antigen design by selecting conserved regions of global HIV-1 and HIV-2 isolates and epitopes from most frequent HLA types of the human population. The new vaccine induced both antibody and CTL responses. Importantly, the authors demonstrated vaccine-specific HLA restricted CD8(+) CTL responses for one HLA allele that was involved in the antigen design. HIV-v vaccine is a new candidate to be tested in human subjects carrying frequent HLA types.

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The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia

David¹,

Naicker²

2023

Obstet Gynecol Sci

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This review assessed the complement system and its activation with respect to the pathological features of severe acute respiratory syndrome (SARS-CoV-2), human immunodeficiency virus (HIV) infection, and preeclampsia (PE). The complement system is the first defensive response of the host innate immune system to viral pathogens, including SARS-Cov-2. SARS-CoV-2 entry results in the release of proinflammatory cytokines and chemical mediators to create a "cytokine storm". Endothelial cell (EC) dysfunction and cell-mediated injury are also observed. These factors exacerbate inflammation.During HIV infection and PE, various complement components are elevated, causing a hyperinflammatory state. Furthermore, EC dysfunction and cell-mediated injury are also observed. The similarities in the pathological aspects of these three disorders may emanate from excessive complement activation. This review serves as a platform for further research on the complement system, coronavirus disease-2019, HIV, and PE.

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Innate Immune Responses in HIV-Infection

Cited by 3 publications

References 144 publications

The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia

HIV Vaccine to Induce Cytotoxic T Cells Recognizing Conserved HIV-1/2-Epitopes Derived from the Most Frequent HLA Types of the Human Population

The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia

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