Innate lymphoid cell memory

Wang, Xianwei; Peng, Hui; Tian, Zhigang

doi:10.1038/s41423-019-0212-6

Cited by 51 publications

(44 citation statements)

References 101 publications

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“…NK cells might directly or indirectly inhibit certain immune cells by producing specific cytokines as described above. There are two distinct NK cell subsets in the liver: liver‐resident NK cells (CD49a + CD49b − ) and conventional NK cells (CD49a ‐ CD49b + ) with distinct phenotypical and developmental features . We considered that the respective roles of liver‐resident NK cells (LrNK) and conventional NK cells (cNK) deserved further investigation during the progression of NASH.…”

Section: Discussionmentioning

confidence: 99%

“…There are two distinct NK cell subsets in the liver: liver-resident NK cells (CD49a + CD49b − ) and conventional NK cells (CD49a -CD49b + ) with distinct phenotypical and developmental features. 25,26 We considered that the respective roles of liver-resident NK cells (LrNK) and conventional NK cells (cNK) deserved further investigation during the progression of NASH. Given that Nfil3 −/− mice are deficient in cNK cells but not LrNK cells, our present data indicated that cNK cells played a protective role in the inflammation and fibrosis progression of NASH ( Figures 6E and 7B).…”

Section: Discussionmentioning

confidence: 99%

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Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

Fan

Zhang

Wei

et al. 2019

Liver International

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Background & Aims Non‐alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease. The precise role of NK cells in the progression of NASH has yet to be elucidated. Methods Using methionine‐ and choline‐deficient diets (MCD)‐induced NASH model, the role of NK cells was identified in WT mice compared with conventional NK cell–deficient Nfil3−/− mice. Results After 8 weeks of MCD treatment, NASH was induced as shown by the significant macrovesicular steatosis, necro‐inflammation and fibrosis in the liver of WT B6 mice. In MCD‐treated WT B6 mice, the number of NK cells was markedly increased in the liver, but decreased in the spleen. Intrahepatic NK cells exhibited high levels of activation, as evidenced by the expression of CD107a and cytokine production of IFN‐γ, TGF‐β and IL‐10. Lower expression levels of Ki67 indicated a reduction in the proliferation of intrahepatic NK cells after MCD treatment. Increased expression of CXCL10 in the liver early after MCD treatment led to the increased recruitment of CXCR3+ NK cells into the liver. The MCD‐treated Nfil3−/− mice showed similar levels of TG and macrovesicular steatosis, thus more inflammatory infiltration and increased collagen deposition in the liver. Furthermore, the depletion of NK cells during MCD‐induced NASH caused a significant increase in the infiltration of monocyte‐derived macrophages (MoMFs) particularly Ly6Clo subsets towards M2. Conclusions Intrahepatic NK cells, recruited through CXCL10‐CXCR3 interaction, play a protective role against the fibrosis progression in NASH, which provide us with a better understanding of the immunopathogenesis of NASH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

Fan

Zhang

Wei

et al. 2019

Liver International

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“…Interestingly, recent investigations have uncovered the ability of ILCs to display features that resemble the trained immune responses of macrophages and the memory-like responses of NK cells (106). These innate memory-like responses of ILCs could be targeted via vaccination ( Figure 1D).…”

Section: Memory Of Ilcs In Tbmentioning

confidence: 99%

Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis

et al. 2020

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Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate of protection in TB. Nonetheless, the demonstration that other cellular subsets offer protective memory responses against Mycobacterium tuberculosis (Mtb) is emerging. Among these are memory-like features of macrophages, myeloid cell precursors, natural killer (NK) cells, and innate lymphoid cells (ILCs). Additionally, the dynamics of B cell memory responses have been recently characterized at different stages of the clinical spectrum of Mtb infection, suggesting a role for B cells in human TB. A better understanding of the immune mechanisms underlying such responses is crucial to better comprehend protective immunity in TB. Furthermore, targeting immune compartments other than CD4+ T cells in TB vaccine strategies may benefit a significant proportion of patients co-infected with Mtb and the human immunodeficiency virus (HIV). Here, we summarize the memory responses of innate immune cells and B cells against Mtb and propose them as novel correlates of protection that could be harnessed in future vaccine development programs.

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“…In other studies, it has been demonstrated that NK cells that recall respiratory influenza virus and skin contact hypersensitive chemical hapten reside in the liver, but not in the infection or sensitization site ( 20 , 76 ). Wang et al further demonstrated that hapten-specific memory NK cells are generated in the lymph nodes ( 23 , 77 ). These findings raise the question of whether the formation and long-term maintenance of memory NK cells requires a unique nutritional and metabolic environment, which differs among tissues.…”

Section: Metabolism and Nk Cell Functionmentioning

confidence: 99%

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

Cong

2020

Front. Immunol.

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Natural killer (NK) cells are the host's first line of defense against tumors and viral infections without prior sensitization. It is increasingly accepted that NK cells belong to the innate lymphoid cell (ILC) family. Other ILCs, comprising ILC1s, ILC2s, ILC3s and lymphoid tissue inducer (LTi) cells, are largely non-cytotoxic, tissue-resident cells, which function to protect local microenvironments against tissue insults and maintain homeostasis. Recently, evidence has accumulated that metabolism supports many aspects of the biology of NK cells and other ILCs, and that metabolic reprogramming regulates their development and function. Here, we outline the current understanding of ILC metabolism, and describe how metabolic processes are affected, and how metabolic defects are coupled to dysfunction of ILCs, in disease settings. Furthermore, we summarize the current and potential directions for immunotherapy involving targeting of ILC metabolism. Finally, we discuss the open questions in the rapidly expanding field of ILC metabolism.

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Innate lymphoid cell memory

Cited by 51 publications

References 101 publications

Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

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