Innovan-N2O anaesthesia in normal men effect on respiration, circulatory dynamics, liver function, metabolic functions, acid-base balance, and psychic responses

Abstract

MUN)3ELEER AND DECASTRO reduced an analgesic a~d sedatwe state for surgmal procedures, without using balblturates or volatile a~aesthetm agents, whmh they called neuroleptanalgesla They employed a comb!#atlon of drugs developed by Janssen m Belgmm to* aecomphsh this state and many anaesthetists are now usmg thas techmque m Europe 1-~ Of the numerous new analgesm and sedatwe ~lrugs recently developed by Janssen, the combination of droperldol (R4749, dehydrobenzpendol, Inapsine| and fentanyl (R4263, phentanyl, Subhmase| an a 50 lk mxxture has been found ' I to provide the most satisfactory anaesthetm eondatmns an both ammals and m man, without causing sermus pl~ysmlogmal disturbances that cannot be controlled effectwely 7 s The pharmaeologma| propertms of these two drugs are summarized m Table I

Hemodynamic Response to Different Anesthetics during Open‐Heart Surgery

“…This state of "inner anxiety" is more likely to occur when dehydrobenzperidol alone is given. The marked anti-emetic effect of dehydrobenzperidol on experimental animals and on man has been described in earlier studies (DOBKIN et al 1964…”

“…These ciharacteristics make it easy to regulate the level of fentanyl analgesia, which approaches the good controllability of inhalation anesthetics. Rigidity of thoracic and abdominal muscles following fast injection of large doses of fentanyl has been described by several teams (DOBKIN et al 1964, CORSSEN et al 1965& FOLDES et d. 1966). The resistance to ventilation is caused by expiratory spas'm of the respiratory muscles.…”

“…The hemodynamic effects of thiopental induction on heart patients has been widely studied. Induction with 150 mg of thiopental caused only a small decrease in the mean arterial pressure and an increase in the heart rate, but intubation was followed by a sharp rise (50 %) in both arterial pressure and heart rate (DOTTORI et al 1970). A mean induction dose of 3.8 mg/kg resulted in a slight fall in arterial pressure, but during intubation again a marked increase of more than 30 % in arterial pressure and heart rate was found (LAEPPLE & ROTH-LIN 1970).…”

“…The onset of action after intravenous injection takes several minutes and the duration of its sedative effect lasts for 6 to 12 hours. However, the circulatory effects of dehydrobenzperidol are shortlived (DOBKIN et al 1964, ZAUDER et al 1965, WHITWAM & RUSSELL 1971, HELMS et al 1975.…”

A comparison of fentanyl, droperidol, and morphine

“…1) is a sedative-tranquilizer drug of the butyrophenone family, also synthesized by Janssen. Pharmacologic studies'" 5,13,20 have indicated that it has adrenergic blocking properties, antiemetic effects, and can cause hypotension, respiratory depression, and extrapyramidal reactions. Studies of fentanyl-droperidol combinations by Yelnosky and Gardockj19 have shown that droperidol, which has no analgesic effects when given alone, potentiates the analgesic actions of fentanyl in mice.…”