Innovations in hydrogel-based manufacturing: A comprehensive review of direct ink writing technique for biomedical applications

Baniasadi, Hossein; Abidnejad, Roozbeh; Fazeli, Mahyar; Lipponen, Juha; Niskanen, Jukka; Kontturi, Eero; Seppälä, Jukka; Rojas, Orlando J.

doi:10.1016/j.cis.2024.103095

Cited by 27 publications

(1 citation statement)

References 171 publications

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“…The concept of rheology, first introduced by the American physicist Bingham in 1928, primarily focuses on studying the deformation and flow behavior of matter under external forces. It finds wide application in fields such as chemical engineering, biomedical engineering, and the food industry [6][7][8]. When it comes to semisolid preparations like ointments, their relevant characteristics can be effectively characterized using a rheometer, which proves integral to the formulation process and the application of ointments.…”

Section: Introductionmentioning

confidence: 99%

Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Qian,

Wang,

et al. 2024

PLoS ONE

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This paper presents an optimized preparation process for external ointment using the Definitive Screening Design (DSD) method. The ointment is a Traditional Chinese Medicine (TCM) formula developed by Professor WYH, a renowned TCM practitioner in Jiangsu Province, China, known for its proven clinical efficacy. In this study, a stepwise regression model was employed to analyze the relationship between key process factors (such as mixing speed and time) and rheological parameters. Machine learning techniques, including Monte Carlo simulation, decision tree analysis, and Gaussian process, were used for parameter optimization. Through rigorous experimentation and verification, we have successfully identified the optimal preparation process for WYH ointment. The optimized parameters included drug ratio of 24.5%, mixing time of 8 min, mixing speed of 1175 rpm, petroleum dosage of 79 g, liquid paraffin dosage of 6.7 g. The final ointment formulation was prepared using method B. This research not only contributes to the optimization of the WYH ointment preparation process but also provides valuable insights and practical guidance for designing the preparation processes of other TCM ointments. This advanced DSD method enhances the screening approach for identifying the best preparation process, thereby improving the scientific rigor and quality of TCM ointment preparation processes.

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Section: Introductionmentioning

confidence: 99%

Refining the rheological characteristics of high drug loading ointment via SDS and machine learning

Qian,

Wang,

et al. 2024

PLoS ONE

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Soft Actuators and Actuation: Design, Synthesis, and Applications

Kalulu,

Chilikwazi,

et al. 2024

Macromol. Rapid Commun.

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Soft actuators are one of the most promising technological advancements with potential solutions to diverse fields’ day‐to‐day challenges. Soft actuators derived from hydrogel materials possess unique features such as flexibility, responsiveness to stimuli, and intricate deformations, making them ideal for soft robotics, artificial muscles, and biomedical applications. This review provides an overview of material composition and design techniques for hydrogel actuators, exploring 3D printing, photopolymerization, cross‐linking, and microfabrication methods for improved actuation. It examines applications of hydrogel actuators in biomedical, soft robotics, bioinspired systems, microfluidics, lab‐on‐a‐chip devices, and environmental, and energy systems. Finally, it discusses challenges, opportunities, advancements, and regulatory aspects related to hydrogel actuators.

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