Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration

Mederle, N.; Marin, Ştefania; Marin, Minodora Maria; Danilă, Elena; Mederle, Ovidiu Alexandru; Kaya, Madalina Georgiana Albu; Ghica, Mihaela Violeta

doi:10.1155/2016/3452171

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…Another particularly important factor is the age. It impacts the prognosis in at least two manners, on one hand, it is intrinsically associated with the HL biology and on the other hand, the old age is often associated with low comorbidity and tolerability of the chemotherapeutic regimens used for younger patients, such treatment can be also model for targeted drug delivery systems [25]. The HL epidemiology is characterized by a bimodal distribution by ages .…”

Section: Resultsmentioning

confidence: 99%

The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors

Pescaru¹,

Oncu²,

Bucur³

et al. 2018

Rev. Chim.

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The Hodgkin lymphoma treatment is adapted to the disease type, disease stage and to an evaluation of the risk. The treatment is focused on the adjustment of the therapy to each patient depending on the age, toxicity risk on short and long term and the relapse risk. The study proposes the evaluation of the response to the treatment further to the administration of different therapeutic regimens as well as the correlation with the negative diagnosis factors of Hodgkin lymphoma. This is a retrospective study on 71 patients diagnosed with Hodgkin lymphoma in the Hematology Department of Timisoara between January 2014 and December 2017. The data obtained have been collected from a database and processed with the SPSS 20.0. software . In our study there were included 71 patients diagnosed with Hodgkin lymphoma with a medium age of 42.12�16.45 years old. By the time of the diagnosis, the patients showed the following hematological, biochemical and immunological parameters. The response to treatment is influenced by the presence of the negative prognosis factors : the age of �40 years old, extralymphatic infiltration, VSH ] 50mm/h , presence of general B signs, more than 3 lymph node sites affected, bulky disease and Ann-Arbor III and IV stages. The treatment of Hodgkin lymphoma is guided by the traditional clinic prognostic factors and by the laboratory which often represent a substitute marker for the biological characteristics which many times are not included in the standard evaluation.

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Section: Resultsmentioning

confidence: 99%

The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors

Pescaru¹,

Oncu²,

Bucur³

et al. 2018

Rev. Chim.

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“…The additive manufacturing (3D printing) of biomaterials offers promising future perspectives for the field of biomedical engineering [ 90 ], especially in regard to patient-specific clinical applications.…”

Section: Stem Cells Biomaterials and Scaffolds For Oral Tissue Ementioning

confidence: 99%

Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review

et al. 2020

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The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent decades, a wide range of both artificial and natural biomaterials and scaffolds, genes, stem cells isolated from the mouth area (dental follicle, deciduous teeth, periodontal ligament, dental pulp, salivary glands, and adipose tissue), and various growth factors have been tested in tissue engineering approaches in dentistry, with many being proven successful. However, to fully eliminate the problems of traditional bone and tissue reconstruction in dentistry, continuous research is needed. Based on a recent literature review, this paper creates a picture of current innovative strategies applying dental stem cells for tissue regeneration in different dental fields and maxillofacial surgery, and offers detailed information regarding the available scientific data and practical applications.

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“…It serves as a support and filler to the bones [13][14][15][16]. Given its incompetence properties, HA is a very promising biomaterial source [17][18][19][20]. In addition, hydroxyapatite (HAp) is also exploited as a model compound to mimic the biomineralization process [21,22].…”

Section: Hydroxyapatite (Ha)mentioning

confidence: 99%

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

Majhooll¹,

Zainol²,

Jaafar³

et al. 2019

JCCE

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Preparation of hydroxyapatite (HA) through natural sources, such as fish scales or synthetic HA produced from the chemical reaction has been widely used as biomedical materials because HA is bioactive, non-toxic and osteoconductive with a crystallographic structure almost similar to that of the bone mineral. In addition, HAwith particle size < 10 microns is classified as common inorganic filler used to improve the mechanical properties and biocompatibility of polymer composites. The purpose of this review is to collect information related to HA, and to provide readers with information about synthesis methods, advantages of hydroxyapatite as biomaterial,biomedical applications of polymer/HA composites.

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Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration

Cited by 14 publications

References 23 publications

The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors

The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors

Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

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