Inorganic analysis

West, Philip W.; West, Foymae K.

doi:10.1021/ac60287a021

Cited by 10 publications

(15 citation statements)

References 69 publications

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“…The complexation of hydrophobic moieties with natural cyclodextrins in water has been intensively investigated since the 1970s . Nevertheless, scientific interest in this class of receptors has not diminished over time.…”

Section: Introductionmentioning

confidence: 99%

Solvophobically Driven Complexation of Adamantyl Mannoside with β‐Cyclodextrin in Water and Structured Organic Solvents

Leko

Hanževački

Brkljača

et al. 2020

Chemistry A European J

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The effects of solventa nd temperature on the complexation of adamantyl mannoside with b-cyclodextrin and 6-O-monotosyl-6-deoxy-b-cyclodextrinw ere explored experimentally and by means of molecular dynamics simulations. Efficientb inding was observedo nly in hydrogenbondeds olvents, which indicated solvophobically driven complexation. Thes tability of the inclusion complex was considerably higheri na queous media. Ap ronouncedt emperature dependence of D r H * and D r S * ,r esulting in perfect enthalpy-entropy compensation, was observedi nw ater.The complexation thermodynamicsw as in line with classical rationale for the hydrophobic effect at lower temperatures and the nonclassical explanation at higher temperatures. This finding linked cyclodextrinc omplexation thermodynam-ics with insights regarding the effecto ft emperature on the hydration water structure. The complexation enthalpies and entropies were weakly dependent on temperature in organic media. The signs of D r H * and D r S * were in accordance with the nonclassicalh ydrophobic (solvophobic) effect.T he structures of the optimized product corresponded to those deduceds pectroscopically,a nd the calculated and experimentally obtained values of D r G * were in very good agreement. This investigation clearly demonstrated that solvophobically drivenf ormation of cyclodextrin complexes could be anticipated in structured solvents in general. However,u nlike in water, adamantane and the host cavity behaved solely as structure breakers in the organic media explored so far.[a] SE = standard error of the mean (N = 3o r4). Figure 6. Relative a) conformation and b) solvation contribution to the hydration enthalpies of reactantsand the complex over the studied temperature range.

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Section: Introductionmentioning

confidence: 99%

Solvophobically Driven Complexation of Adamantyl Mannoside with β‐Cyclodextrin in Water and Structured Organic Solvents

Leko

Hanževački

Brkljača

et al. 2020

Chemistry A European J

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“…First, it should be said that a large portion of analytes (typically about 50% ) can be eluted satisfactorily from many good columns without the need for an additive. It is also important to note that compounds which exhibit satisfactory elution in the absence of an additive are most often unaffected by the presence of an additive .…”

Section: Chromatographic Conditions For Sfc Analysis Of Drug Moleculesmentioning

confidence: 99%

“…The use of preparative SFC in pharmaceutical companies is also covered. It was not our intention to present a comprehensive review of the literature, that may be found in other interesting reviews , but rather to point at significant features of SFC as they apply in the field of drug analysis.…”

Section: Introductionmentioning

confidence: 99%

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Lemasson

Bertin

West

2016

J of Separation Science

101

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The interest of pharmaceutical companies for complementary high-performance chromatographic tools to assess a product's purity or enhance this purity is on the rise. The high-throughput capability and economic benefits of supercritical fluid chromatography, but also the "green" aspect of CO2 as the principal solvent, render supercritical fluid chromatography very attractive for a wide range of pharmaceutical applications. The recent reintroduction of new robust instruments dedicated to supercritical fluid chromatography and the progress in stationary phase technology have also greatly benefited supercritical fluid chromatography. Additionally, it was shown several times that supercritical fluid chromatography could be orthogonal to reversed-phase high-performance liquid chromatography and could efficiently compete with it. Supercritical fluid chromatography is an adequate tool for small molecules of pharmaceutical interest: synthetic intermediates, active pharmaceutical ingredients, impurities, or degradation products. In this review, we first discuss about general chromatographic conditions for supercritical fluid chromatography analysis to better suit compounds of pharmaceutical interest. We also discuss about the use of achiral and chiral supercritical fluid chromatography for analytical purposes and the recent applications in these areas. The use of preparative supercritical fluid chromatography by pharmaceutical companies is also covered.

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“…Highly enantioselective separation approaches are therefore needed, which are conventionally either based on the use of chiral columns, the derivatization of both enantiomers, or the use of a chiral selector. A large diversity of analytical strategies have been reported so far, mostly based on gas chromatography [18][19][20], liquid chromatography [21][22][23][24][25][26][27], and supercritical fluid chromatography [28][29][30][31]. Next to these chromatographic approaches, CE represents an excellent alternative for chiral analysis.…”

Section: Introductionmentioning

confidence: 99%

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

2020

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Past, present, and future developments in enantioselective analysis using capillary electromigration techniques Enantioseparation of chiral products has become increasingly important in a large diversity of academic and industrial applications. The separation of chiral compounds is inherently challenging and thus requires a suitable analytical technique that can achieve high resolution and sensitivity. In this context, CE has shown remarkable results so far. Chiral CE offers an orthogonal enantioselectivity and is typically considered less costly than chromatographic techniques, since only minute amounts of chiral selectors are needed. Several CE approaches have been developed for chiral analysis, including chiral EKC and chiral CEC. Enantioseparations by EKC benefit from the wide variety of possible pseudostationary phases that can be employed. Chiral CEC, on the other hand, combines chromatographic separation principles with the bulk fluid movement of CE, benefitting from reduced band broadening as compared to pressure-driven systems. Although UV detection is conventionally used for these approaches, MS can also be considered. CE-MS represents a promising alternative due to the increased sensitivity and selectivity, enabling the chiral analysis of complex samples. The potential contamination of the MS ion source in EKC-MS can be overcome using partial-filling and counter-migration techniques. However, chiral analysis using monolithic and open-tubular CEC-MS awaits additional method validation and a dedicated commercial interface. Further efforts in chiral CE are expected toward the improvement of existing techniques, the development of novel pseudostationary phases, and establishing the use of chiral ionic liquids, molecular imprinted polymers, and metalorganic frameworks. These developments will certainly foster the adoption of CE(-MS) as a well-established technique in routine chiral analysis.

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Inorganic analysis

Cited by 10 publications

References 69 publications

Solvophobically Driven Complexation of Adamantyl Mannoside with β‐Cyclodextrin in Water and Structured Organic Solvents

Solvophobically Driven Complexation of Adamantyl Mannoside with β‐Cyclodextrin in Water and Structured Organic Solvents

Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

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