Inorganic Nanoparticles in Bone Healing Applications

Burdușel, Alexandra-Cristina; Gherasim, Oana; Andronescu, Ecaterina; Grumezescu, Alexandru Mihai; Ficai, Anton

doi:10.3390/pharmaceutics14040770

Cited by 35 publications

(22 citation statements)

References 529 publications

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“…The materials (M0) are biocompatible and utilised as bone replacements. It was accepted with the findings in [18]. Unlike other research Aroni et al, [19], that employed various materials such deproteinized bovine bone (DBB) particles, this study allowed nanoparticles to provide a framework for new bone development.…”

Section: Osteoid Tissue Formationmentioning

confidence: 63%

use of nanoparticle form of milled teeth as a bone graft substitute in rabbits

Mohammed

Rejeb

2022

ijhs

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Aims of the study: This study was designed to determine the effects of milled tooth in its nanoparticle forms as a bone substitute materials on the acceleration of bone healing in rabbits. Materials and Methods: Sixteen albino rabbits were used in the experiment that were divided into two groups: nanoparticle group (M0 group) and control group. Rabbits were anesthetized using intramuscularly administered 10% ketamine (40mgkg) and 2% xylazine (5mgkg) (Inferchemi, Holland). After shaving and sterilization of the site of the operation, a 2cm submandibular incision was done. Then 3 millimeter circular anterior full-thickness defect was created near the midline of the mandible. The anterior defect was filled with 50-100nm milled tooth material nanoparticles. The incision was sutured with 3/0 black silk. Following surgery, each rabbit was given 30 mg/kg oxytetracycline intramuscularly. The rabbits were euthanized at 3, 7, 14, and 28 days afterwards. Then the specimens were dried and fixed in paraffin before being removed from the skulls. Histological examination the specimens was done.

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Section: Osteoid Tissue Formationmentioning

confidence: 63%

use of nanoparticle form of milled teeth as a bone graft substitute in rabbits

Mohammed

Rejeb

2022

ijhs

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“…Since that nanoparticles have multiple advantages including high drug loading capacity, good biocompatibility, and the ability of the controlling drug release, they have been widely employed in investigations on tissue repair. As a drug carrier or antibacterial active substance, nanoparticles are applied to skin damage repair by mixing with hydrogel to form composite hydrogel (Sun et al, 2021;Burdusel et al, 2022;Qin P. et al, 2022). Silver particles, titanium oxide, gentamicin-containing nanoparticles, curcumincontaining nanoparticles, and other composite hydrogels have been confirmed to have anti-bacterial and wound healing-promoting effects (Javanmardi et al, 2018;Zahiri et al, 2020;Xiang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization

Yang

Shi

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Wound healing is a complicated process involving multiple cell components and can help the re-establishment of the skin’s barrier function. Previous studies have pointed out that bacterial infection and sustained inflammatory reactions are the main causes of the delay of wound closure and scar formation during wound healing. The effect of current approaches for scar-free wound repair still faces many challenges, and alternative therapeutic methods are urgently needed to be established.Methods: The basic characteristics of the new-designed nanoparticles were clarified through the characterization of the material. The biocompatibility of the nanoparticles, as well as its effect on fibroblast function, anti-bacterial capacity, inflammation suppressive role, and the underlying mechanism were further verified by a panel of biochemical assays in vitro. Ultimately, pre-clinical rat model was employed to testify its role in wound healing and scar formation in vivo.Results: Firstly, gallium-modified gelatin nanoparticles loaded with quercetin was successfully established, displaying good biocompatibility and facilitative effect on fibroblast function. In addition, the nanoparticles showed prominent anti-bacterial and inflammation-suppressive effects. What’s more important, the nanoparticles could also induce the polarization of macrophages from M1 to M2 phenotype to exert its inflammatory inhibitory role through TGF-β/Smad signaling pathway. Ultimately, in vivo experiment showed that the nanoparticles could effectively promote wound repair and inhibit scar formation during the process of wound healing.Conclusion: Taken together, the new nanoparticles have good anti-bacterial and anti-scar formation effects and great potential in the field of skin wound repair, which provides a promising therapeutic strategy for wound treatment.

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“…4 ). Inorganic NPs has been reported to provide promising outcome in bone healing applications [ 123 ]. Among them, the nHAp is the most widely used, which is regarded as a plentiful source of free calcium and a key factor in mineralization and alveolar [ 124 ].…”

Section: Hydrogel-based Mandibular Tissue Engineeringmentioning

confidence: 99%