iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach

Metabonomic Changes Associated with Atherosclerosis Progression for LDLR–/– Mice

“…Article sclerotic lesions, 51 indicating the occurrence of the proatherosclerotic oxidative stress and inflammation. 52 In this study, we paid particular attention to whether diet switch (to normal chow after 6 weeks of WD feeding) reversed the WD effects and to what degree, which was not reported for the time being although closely relevant to the effects of diet management on atherosclerosis development.…”

Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine- 3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats

“…The consequences of the observed outburst of mRNA expression could be levelled by post-transcriptional processing. Expression of the Parp1 gene related to DNA repair and induced by DNA breakage resembled to a large extent the pattern of the iNos gene expression, co-ordinate expression of these genes is due to common Nrf-2 pathway of their regulation (36,37). Thus, 1,4-DHPs increased the expression of the gene in kidneys of both intact and diabetic animals.…”

Effects of an Antimutagenic 1,4‐Dihydropyridine AV‐153 on Expression of Nitric Oxide Synthases and DNA Repair‐related Enzymes and Genes in Kidneys of Rats with a Streptozotocin Model of Diabetes Mellitus

“…iNOS expression is triggered by the nuclear factor-kappa B (NF-jB); the latter is up-regulated by hyperglycaemia-induced oxidative stress and after protein nitration [28]. iNOS expression foci colocalize with poly(ADP)ribose synthesis sites; thus, PARP1 and iNOS action is co-ordinated [29], and genes of these enzymes are regulated in a common Nrf-2 pathway [30]. The ability to decrease iNOS expression is considered to be a positive feature in search for novel remedies for the treatment of diabetic nephropathy [31].…”