2008
DOI: 10.1161/circulationaha.107.728840
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Inotropes and Vasopressors

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Cited by 409 publications
(256 citation statements)
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References 91 publications
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“…Antibiotics and hemodynamic support, which includes volume resuscitation and use of vasopressors in severe cases are the mainstay therapy (9). Current sepsis treatment guidelines recommend norepinephrine, dopamine and dobutamine as first line vasopressor agents, they may not be the ideal choice in the setting of active or recurrent arrhythmias (9) in view of their pro-arrhythmic properties (33). Despite lack of data to support this, in view of their virtual lack of affinity for beta receptors it appears intuitive to use vasopressors such as phenylephrine and (33).…”
Section: Discussionmentioning
confidence: 99%
“…Antibiotics and hemodynamic support, which includes volume resuscitation and use of vasopressors in severe cases are the mainstay therapy (9). Current sepsis treatment guidelines recommend norepinephrine, dopamine and dobutamine as first line vasopressor agents, they may not be the ideal choice in the setting of active or recurrent arrhythmias (9) in view of their pro-arrhythmic properties (33). Despite lack of data to support this, in view of their virtual lack of affinity for beta receptors it appears intuitive to use vasopressors such as phenylephrine and (33).…”
Section: Discussionmentioning
confidence: 99%
“…dobutamine) could have potentially caused excessive tachycardia and worsened the transmitral pressure gradient and pulmonary congestion (due to increased EVLWI). 5 This could have led to a deterioration in oxygenation. Arguably, common practices to augment cerebral blood flow in vasospastic areas without compromising myocardial function and oxygenation are not themselves free of complications.…”
Section: Discussionmentioning
confidence: 99%
“…This was in view of the ability of noradrenaline to prevent the reflex bradycardia associated with a raised MAP. 5 However, the physiological parameters worsened (i.e. increased SVR index and EVLWI with decreased cardiac output) following the augmentation of the MAP using a noradrenaline infusion alone.…”
Section: Discussionmentioning
confidence: 99%
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“…At higher indusion rates (>10 μg/kg/min), vasoconstriction predominates (5). Dopamine is useful in the management of patients with cardiogenic shock or, at low doses, to augment diuresis (6,13). Like all positive inotropic agents, dopamine can result in myocardial ischemia and may be associated with splanchnic shunting, impairment of gastric mucosal oxygentation, and increased risk of gastrointestinal bleeding.…”
Section: Inotropes With Vasopressor Activitiesmentioning
confidence: 99%