Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis

Jewett, Cayla E.; Prekeris, Rytis

doi:10.1111/tra.12579

Cited by 52 publications

(61 citation statements)

References 106 publications

(174 reference statements)

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“…These cells now undergo a mesenchymal–epithelial transition and form a lumen. The mechanisms of lumen formation are not known, but presumably it involves either cavitation and/or cord hollowing (see reviews by Lubarsky & Krasnow, ; Andrew & Ewald, ; Jewett & Prekeris, ).…”

Section: ‘Before I Can Connect I Need To Undergo Tubulogenesis Elongmentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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Background:The mechanisms by which the rete testis joins the efferent ducts, which joins the Wolffian duct during development, are not known. Mouse and chick models have been helpful in identifying genes that are important for the development of each part, but genes have not been identified as to those that play a role in the joining of each part. Clinical implications of the failure of the male reproductive tract to form a fully functional conduit for spermatozoa are not trivial. Epididymal disjunction, the failure of the efferent ducts to join the testis, is one of several epididymal anomalies that have been observed in some boys who were cryptorchid at birth. Objective: A systematic review of studies focusing on the morphogenesis of the mesonephric duct and mesonephric tubules in different species, and identification of clinical issues should there be failure of these tissues to develop. Design: PubMed and GUDMAP databases, and review of books on kidney development were searched for studies reporting on the mechanisms of morphogenesis of the kidney and epididymis. Main outcomes measure(s): Gaps in our knowledge were identified, and hypotheses coupled with suggestions for future experiments were presented. Results: A total of 64 papers were identified as relevant, of which 53 were original research articles and 11 were book chapters and reviews covering morphogenesis and clinical issues. Investigators utilized multiple species including, human, mouse, chick, Xenopus, bovine, and sheep. Conclusion: Fundamental understanding of the morphogenesis of the male reproductive tract is limited, especially the morphogenesis of the rete testis and efferent ducts. Therefore, it is not surprising that we do not understand how each part unites to form a whole. Only one mechanism of joining of one part of the tract to another was identified: the joining of the Wolffian duct to the cloaca via controlled apoptosis.

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Section: ‘Before I Can Connect I Need To Undergo Tubulogenesis Elongmentioning

confidence: 99%

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Santos

Hinton

2019

Andrology

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“…Most organs contain epithelial cells, and understanding the mechanisms of epithelial cell morphogenesis is a key goal of cell and developmental biology. Regulation of the actomyosin and microtubule cytoskeletons, polarized delivery of proteins and variation in lipid composition all contribute to the polarization and morphogenesis of epithelial cells (Apodaca et al, 2012;Braga, 2016;Crawley et al, 2014;Jewett and Prekeris, 2018;Rodriguez-Boulan and Macara, 2014). The small GTPase cell division control protein 42-homolog (Cdc42) has been shown to influence all of these processes, making this factor an essential regulator of epithelial morphogenesis.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Cdc42 and its effectors in epithelial morphogenesis

Pichaud

Walther

Almeida

2019

Journal of Cell Science

102

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Cdc42a member of the small Rho GTPase familyregulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen formation and junction maturation. In parallel, work in yeast and Caenorhabditis elegans has provided important clues as to how this molecular switch can generate and regulate polarity through localized activation or inhibition, and cytoskeleton regulation. Recent studies have revealed how important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21activated kinase (PAK) family, myotonic dystrophy-related Cdc42 binding kinase beta (MRCKβ, also known as CDC42BPB) and neural Wiskott-Aldrich syndrome protein (N-WASp, also known as WASL).Here, we review how the spatial regulation of Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type.

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“…Apicobasal polarity occurs when complexes that include PAR-3, PAR-6 and PKC-3 localize apically, whereas other complexes such as those containing LET-413/Scribble are restricted basally (Etemad-Moghadam et al, 1995;Hung and Kemphues, 1999;McMahon et al, 2001). Many factors contribute to the onset and establishment of this asymmetric segregation of proteins, including the trafficking and turnover of active Cdc42, actomyosin organization, asymmetric distribution of specific phospholipids, adhesion junctions and mutual antagonism (Jiang et al, 2015;Jewett and Prekeris, 2018;Motegi et al, 2020). In C. elegans, intestinal cells acquire apicobasal polarity, which is crucial for formation of the interior lumen (Leung et al, 1999;Bernadskaya et al, 201;Shafaq-Zadah et al, 2012;Rasmussen et al, 2012;Bossinger et al 2015;Asan et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Multi-tissue patterning drives anterior morphogenesis of theC. elegansembryo

Grimbert

Mastronardi

Christensen

et al. 2020

Preprint

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Complex structures derived from multiple tissue types are challenging to study in vivo, and our knowledge of how cells from different tissues are coordinated is limited. Model organisms have proven invaluable for improving our understanding of how chemical and mechanical cues between cells from two different tissues can govern specific morphogenetic events. Here we usedCaenorhabditis elegans as a model system to show how cells from three different tissues are coordinated to give rise to the anterior lumen. This poorly understood process has remained a black box for embryonic morphogenesis. Using various microscopy and software approaches, we describe the movements and patterns of epidermal cells, neuroblasts and pharyngeal cells that contribute to lumen formation. The anterior-most pharyngeal cells (arcade cells) may provide the first marker for the location of the future lumen and facilitate the patterning of the surrounding neuroblasts. These neuroblast patterns control the rate of migration of the anterior epidermal cells, whereas the epidermal cells ultimately reinforce and control the position of the future lumen, as they must join with the pharyngeal cells for their epithelialization. Our studies are the first to characterize anterior morphogenesis in C. elegans in detail and should lay the framework for identifying how these different patterns are controlled at the molecular level.

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Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis

Cited by 52 publications

References 106 publications

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect

Regulation of Cdc42 and its effectors in epithelial morphogenesis

Multi-tissue patterning drives anterior morphogenesis of theC. elegansembryo

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